YAP4_YEAST - dbPTM
YAP4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YAP4_YEAST
UniProt AC P40917
Protein Name AP-1-like transcription factor YAP4
Gene Name CIN5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 295
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements. According to genome-wide promoter binding and gene expression studies it regulates, among others, genes involved in ribosome biogenesis, and protein synthesis. It may also be involved in pleiotropic drug resistance. When overexpressed it confers increased resistance to cisplatin, the DNA-alkylating agents methylmethanosulfonate, and mitomycin C, the antimalarial drugs quinidine, mefloquine, and chloroquine, and increases cellular tolerance to sodium and lithium. Preferentially binds 5'-TTACTAA-3'..
Protein Sequence MLMQIKMDNHPFNFQPILASHSMTRDSTKPKKMTDTAFVPSPPVGFIKEENKADLHTISVVASNVTLPQIQLPKIATLEEPGYESRTGSLTDLSGRRNSVNIGALCEDVPNTAGPHIARPVTINNLIPPSLPRLNTYQLRPQLSDTHLNCHFNSNPYTTASHAPFESSYTTASTFTSQPAASYFPSNSTPATRKNSATTNLPSEERRRVSVSLSEQVFNEGERYNNDGQLIGKTGKPLRNTKRAAQNRSAQKAFRQRREKYIKNLEEKSKLFDGLMKENSELKKMIESLKSKLKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41PhosphorylationTDTAFVPSPPVGFIK
CCCCEECCCCCCCCC		36.2121551504
77PhosphorylationIQLPKIATLEEPGYE
CCCCEEEEECCCCCC		37.8723749301
83PhosphorylationATLEEPGYESRTGSL
EEECCCCCCCCCCCC		22.8028889911
85PhosphorylationLEEPGYESRTGSLTD
ECCCCCCCCCCCCCC		27.0222369663
87PhosphorylationEPGYESRTGSLTDLS
CCCCCCCCCCCCCCC		40.1622369663
89PhosphorylationGYESRTGSLTDLSGR
CCCCCCCCCCCCCCC		27.7322369663
91PhosphorylationESRTGSLTDLSGRRN
CCCCCCCCCCCCCCC		36.2722369663
94PhosphorylationTGSLTDLSGRRNSVN
CCCCCCCCCCCCCCC		32.8222369663
99PhosphorylationDLSGRRNSVNIGALC
CCCCCCCCCCHHHHC		18.0923607784
192PhosphorylationPSNSTPATRKNSATT
CCCCCCCCCCCCCCC		43.3028889911
194UbiquitinationNSTPATRKNSATTNL
CCCCCCCCCCCCCCC		51.3922106047
196PhosphorylationTPATRKNSATTNLPS
CCCCCCCCCCCCCCH		29.9922369663
198PhosphorylationATRKNSATTNLPSEE
CCCCCCCCCCCCHHH		18.9522369663
199PhosphorylationTRKNSATTNLPSEER
CCCCCCCCCCCHHHH		34.1822369663
203PhosphorylationSATTNLPSEERRRVS
CCCCCCCHHHHHCCE		56.0822369663
210PhosphorylationSEERRRVSVSLSEQV
HHHHHCCEEEHHHHH		12.2729650682
212PhosphorylationERRRVSVSLSEQVFN
HHHCCEEEHHHHHHC		20.7621440633
214PhosphorylationRRVSVSLSEQVFNEG
HCCEEEHHHHHHCCC		20.6219779198
261PhosphorylationFRQRREKYIKNLEEK
HHHHHHHHHHHHHHH		16.6328889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
192TPhosphorylationKinasePKA-FAMILY-GPS
196SPhosphorylationKinaseGSK-FAMILY-GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YAP4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YAP4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RMR1_YEASTRMR1physical
18719252
PFKA1_YEASTPFK1genetic
19269370
PHO80_YEASTPHO80genetic
19269370
TOP1_YEASTTOP1genetic
19269370
KCC2_YEASTCMK2genetic
19269370
SIN3_YEASTSIN3genetic
20959818
SIP4_YEASTSIP4genetic
20959818
SNT1_YEASTSNT1genetic
20959818
LEO1_YEASTLEO1genetic
20959818
IES1_YEASTIES1genetic
20959818
UBP3_YEASTUBP3genetic
20959818
SRS2_YEASTSRS2genetic
21459050
BUB1_YEASTBUB1genetic
21127252
SOK2_YEASTSOK2genetic
21127252
H2AZ_YEASTHTZ1genetic
21127252
KCS1_YEASTKCS1genetic
21127252
SIN3_YEASTSIN3genetic
21127252
PHO80_YEASTPHO80genetic
21127252
RSC2_YEASTRSC2genetic
21127252
RTG3_YEASTRTG3genetic
21127252
MET18_YEASTMET18genetic
21127252
AFT1_YEASTAFT1genetic
21127252
VPS71_YEASTVPS71genetic
21127252
RAD52_YEASTRAD52genetic
21127252
RAD51_YEASTRAD51genetic
21127252
KCC2_YEASTCMK2genetic
21127252
CG11_YEASTCLN1genetic
21127252
ICS2_YEASTICS2genetic
27708008
H2A2_YEASTHTA2genetic
27708008
YBQ6_YEASTYBR056Wgenetic
27708008
ADPP_YEASTYSA1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
TRM1_YEASTTRM1genetic
27708008
LSM6_YEASTLSM6genetic
27708008
MIG1_YEASTMIG1genetic
27708008
TOS3_YEASTTOS3genetic
27708008
UPF3_YEASTUPF3genetic
27708008
DBF2_YEASTDBF2genetic
27708008
ASK10_YEASTASK10genetic
27708008
UBR1_YEASTUBR1genetic
27708008
PMT6_YEASTPMT6genetic
27708008
VID28_YEASTVID28genetic
27708008
AIM19_YEASTAIM19genetic
27708008
VHS2_YEASTVHS2genetic
27708008
ALLC_YEASTDAL2genetic
27708008
YJE3_YEASTYJL043Wgenetic
27708008
YJU6_YEASTYJL206Cgenetic
27708008
AP2S_YEASTAPS2genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
DBP7_YEASTDBP7genetic
27708008
CSF1_YEASTCSF1genetic
27708008
FMP27_YEASTFMP27genetic
27708008
GIS4_YEASTGIS4genetic
27708008
ERG6_YEASTERG6genetic
27708008
NU188_YEASTNUP188genetic
27708008
TGS1_YEASTTGS1genetic
27708008
GLRX5_YEASTGRX5genetic
28520713
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YAP4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-89; SER-196 ANDTHR-198, AND MASS SPECTROMETRY.

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