VID28_YEAST - dbPTM
VID28_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VID28_YEAST
UniProt AC P40547
Protein Name Vacuolar import and degradation protein 28
Gene Name VID28
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 921
Subcellular Localization Nucleus . Cytoplasm .
Protein Description Has a role in the negative regulation of gluconeogenesis. Required for both proteasome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase)..
Protein Sequence MTVAYSLENLKKISNSLVGDQLAKVDYFLAPKCQIFQCLLSIEQSDGVELKNAKLDLLYTLLHLEPQQRDIVGTYYFDIVSAIYKSMSLASSFTKNNSSTNYKYIKLLNLCAGVYPNCGFPDLQYLQNGFIQLVNHKFLRSKCKIDEVVTIIELLKLFLLVDEKNCSDFNKSKFMEEEREVTETSHYQDFKMAESLEHIIVKISSKYLDQISLKYIVRLKVSRPASPSSVKNDPFDNKGVDCTRAIPKKINISNMYDSSLLSLALLLYLRYHYMIPGDRKLRNDATFKMFVLGLLKSNDVNIRCVALKFLLQPYFTEDKKWEDTRTLEKILPYLVKSFNYDPLPWWFDPFDMLDSLIVLYNEITPMNNPVLTTLAHTNVIFCILSRFAQCLSLPQHNEATLKTTTKFIKICASFAASDEKYRLLLLNDTLLLNHLEYGLESHITLIQDFISLKDEIKETTTESHSMCLPPIYDHDFVAAWLLLLKSFSRSVSALRTTLKRNKIAQLLLQILSKTYTLTKECYFAGQDFMKPEIMIMGITLGSICNFVVEFSNLQSFMLRNGIIDIIEKMLTDPLFNSKKAWDDNEDERRIALQGIPVHEVKANSLWVLRHLMYNCQNEEKFQLLAKIPMNLILDFINDPCWAVQAQCFQLLRNLTCNSRKIVNILLEKFKDVEYKIDPQTGNKISIGSTYLFEFLAKKMRLLNPLDTQQKKAMEGILYIIVNLAAVNENKKQLVIEQDEILNIMSEILVETTTDSSSNGNDSNLKLACLWVLNNLLWNSSVSHYTQYAIENGLEPGHSPSDSENPQSTVTIGYNESVAGGYSRGKYYDEPDGDDSSSNANDDEDDDNDEGDDEGDEFVRTPAAKGSTSNVQVTRATVERCRKLVEVGLYDLVRKNITDESLSVREKARTLLYHMDLLLKVK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
222PhosphorylationYIVRLKVSRPASPSS
EEEEEEECCCCCCCC		30.8424961812
226PhosphorylationLKVSRPASPSSVKND
EEECCCCCCCCCCCC		28.1821551504
228PhosphorylationVSRPASPSSVKNDPF
ECCCCCCCCCCCCCC		45.3124961812
229PhosphorylationSRPASPSSVKNDPFD
CCCCCCCCCCCCCCC		40.2624961812
253PhosphorylationIPKKINISNMYDSSL
CCCCCCCCCCCCHHH		15.8527017623
256PhosphorylationKINISNMYDSSLLSL
CCCCCCCCCHHHHHH		19.5427017623
258PhosphorylationNISNMYDSSLLSLAL
CCCCCCCHHHHHHHH		12.8527017623
262PhosphorylationMYDSSLLSLALLLYL
CCCHHHHHHHHHHHH		19.5227017623
835PhosphorylationDEPDGDDSSSNANDD
CCCCCCCCCCCCCCC		40.1721440633
836PhosphorylationEPDGDDSSSNANDDE
CCCCCCCCCCCCCCC		34.3121440633
837PhosphorylationPDGDDSSSNANDDED
CCCCCCCCCCCCCCC		43.8621440633
864UbiquitinationFVRTPAAKGSTSNVQ
HCCCCCCCCCCCCCE		56.3423749301
873PhosphorylationSTSNVQVTRATVERC
CCCCCEEEHHHHHHH		9.4819779198
876PhosphorylationNVQVTRATVERCRKL
CCEEEHHHHHHHHHH		21.4319779198
900PhosphorylationRKNITDESLSVREKA
HCCCCCCCCHHHHHH		28.8427214570
902PhosphorylationNITDESLSVREKART
CCCCCCCHHHHHHHH		28.5428889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VID28_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VID28_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VID28_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FYV10_YEASTFYV10physical
16554755
ODPA_YEASTPDA1genetic
17314980
MTC4_YEASTMTC4genetic
17314980
VID30_YEASTVID30genetic
17986252
TXTP_YEASTCTP1genetic
20093466
STE50_YEASTSTE50genetic
20093466
THRC_YEASTTHR4genetic
20093466
S2538_YEASTYDL119Cgenetic
20093466
MDHP_YEASTMDH3genetic
20093466
AK_YEASTHOM3genetic
20093466
CEM1_YEASTCEM1genetic
20093466
AIM11_YEASTAIM11genetic
20093466
ODPA_YEASTPDA1genetic
20093466
MTO1_YEASTMTO1genetic
20093466
YGY5_YEASTYGL235Wgenetic
20093466
MTC3_YEASTMTC3genetic
20093466
ATG1_YEASTATG1genetic
20093466
XRN1_YEASTXRN1genetic
20093466
AAKG_YEASTSNF4genetic
20093466
TFS2_YEASTDST1genetic
20093466
CBP4_YEASTCBP4genetic
20093466
UBR1_YEASTUBR1genetic
20093466
NPR3_YEASTNPR3genetic
20093466
RS27B_YEASTRPS27Bgenetic
20093466
MED20_YEASTSRB2genetic
20093466
HTD2_YEASTHTD2genetic
20093466
PTH_YEASTPTH1genetic
20093466
RPA34_YEASTRPA34genetic
20093466
MRX5_YEASTYJL147Cgenetic
20093466
LPLA_YEASTAIM22genetic
20093466
VPS55_YEASTVPS55genetic
20093466
YJ24_YEASTKCH1genetic
20093466
SDHA_YEASTSDH1genetic
20093466
COXM1_YEASTCMC1genetic
20093466
HAP4_YEASTHAP4genetic
20093466
CYT2_YEASTCYT2genetic
20093466
IXR1_YEASTIXR1genetic
20093466
SA190_YEASTSAP190genetic
20093466
COX12_YEASTCOX12genetic
20093466
UPS1_YEASTUPS1genetic
20093466
LIPB_YEASTLIP2genetic
20093466
DIC1_YEASTDIC1genetic
20093466
COX8_YEASTCOX8genetic
20093466
RCF1_YEASTRCF1genetic
20093466
TSA1_YEASTTSA1genetic
20093466
GIS4_YEASTGIS4genetic
20093466
MSS1_YEASTMSS1genetic
20093466
YM35_YEASTYMR160Wgenetic
20093466
SKY1_YEASTSKY1genetic
20093466
COX7_YEASTCOX7genetic
20093466
SCS7_YEASTSCS7genetic
20093466
ADE_YEASTAAH1genetic
20093466
ODP2_YEASTLAT1genetic
20093466
COX5A_YEASTCOX5Agenetic
20093466
PET8_YEASTPET8genetic
20093466
COQ2_YEASTCOQ2genetic
20093466
SDHF2_YEASTSDH5genetic
20093466
PHO80_YEASTPHO80genetic
20093466
LIPA_YEASTLIP5genetic
20093466
FABD_YEASTMCT1genetic
20093466
MRS2_YEASTMRS2genetic
20093466
HAP5_YEASTHAP5genetic
20093466
FUMH_YEASTFUM1genetic
20093466
NCBP2_YEASTCBC2genetic
20093466
MSS18_YEASTMSS18genetic
20093466
QCR2_YEASTQCR2genetic
20093466
HSP72_YEASTSSA2physical
22940862
KPYK1_YEASTCDC19physical
22940862
PABP_YEASTPAB1physical
22940862
HSP71_YEASTSSA1physical
22940862
VID30_YEASTVID30genetic
23227176
GID4_YEASTVID24physical
23393132
COPE_YEASTSEC28physical
23393132
VID30_YEASTVID30physical
23393132
ATG1_YEASTATG1genetic
22282571
RRP1_YEASTRRP1genetic
27708008
VMA21_YEASTVMA21genetic
27708008
CBT1_YEASTCBT1genetic
27708008
ERG6_YEASTERG6genetic
27708008
IDH2_YEASTIDH2genetic
27708008
ARP2_YEASTARP2genetic
27708008
TCPD_YEASTCCT4genetic
27708008
NUP57_YEASTNUP57genetic
27708008
NMT_YEASTNMT1genetic
27708008
TIM23_YEASTTIM23genetic
27708008
CH10_YEASTHSP10genetic
27708008
OSH1_YEASTSWH1genetic
27708008
ETR1_YEASTETR1genetic
27708008
CSG2_YEASTCSG2genetic
27708008
YBQ6_YEASTYBR056Wgenetic
27708008
ODPB_YEASTPDB1genetic
27708008
TXTP_YEASTCTP1genetic
27708008
STE50_YEASTSTE50genetic
27708008
SNT1_YEASTSNT1genetic
27708008
MDHP_YEASTMDH3genetic
27708008
S2538_YEASTYDL119Cgenetic
27708008
AAD4_YEASTAAD4genetic
27708008
ODO2_YEASTKGD2genetic
27708008
SAC3_YEASTSAC3genetic
27708008
SND1_YEASTYDR186Cgenetic
27708008
GNTK_YEASTYDR248Cgenetic
27708008
SNF1_YEASTSNF1genetic
27708008
AK_YEASTHOM3genetic
27708008
CEM1_YEASTCEM1genetic
27708008
AIM11_YEASTAIM11genetic
27708008
PT122_YEASTPET122genetic
27708008
CHAC_YEASTGCG1genetic
27708008
ODPA_YEASTPDA1genetic
27708008
DLDH_YEASTLPD1genetic
27708008
TFS2_YEASTDST1genetic
27708008
XRN1_YEASTXRN1genetic
27708008
MTC3_YEASTMTC3genetic
27708008
MTO1_YEASTMTO1genetic
27708008
RS25A_YEASTRPS25Agenetic
27708008
CBP4_YEASTCBP4genetic
27708008
UBR1_YEASTUBR1genetic
27708008
NPR3_YEASTNPR3genetic
27708008
MED20_YEASTSRB2genetic
27708008
HTD2_YEASTHTD2genetic
27708008
PTH_YEASTPTH1genetic
27708008
LPLA_YEASTAIM22genetic
27708008
MRX5_YEASTYJL147Cgenetic
27708008
RPA34_YEASTRPA34genetic
27708008
SET2_YEASTSET2genetic
27708008
YJ24_YEASTKCH1genetic
27708008
PTK2_YEASTPTK2genetic
27708008
IXR1_YEASTIXR1genetic
27708008
VPS24_YEASTVPS24genetic
27708008
FABG_YEASTOAR1genetic
27708008
HAP4_YEASTHAP4genetic
27708008
COXM1_YEASTCMC1genetic
27708008
SA190_YEASTSAP190genetic
27708008
FPS1_YEASTFPS1genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
UPS1_YEASTUPS1genetic
27708008
LIPB_YEASTLIP2genetic
27708008
MMS22_YEASTMMS22genetic
27708008
ATP10_YEASTATP10genetic
27708008
COX8_YEASTCOX8genetic
27708008
RCF1_YEASTRCF1genetic
27708008
MSS1_YEASTMSS1genetic
27708008
YM35_YEASTYMR160Wgenetic
27708008
COX7_YEASTCOX7genetic
27708008
SCS7_YEASTSCS7genetic
27708008
PET8_YEASTPET8genetic
27708008
COX5A_YEASTCOX5Agenetic
27708008
ODP2_YEASTLAT1genetic
27708008
EOS1_YEASTEOS1genetic
27708008
PHO80_YEASTPHO80genetic
27708008
SDHF2_YEASTSDH5genetic
27708008
HST3_YEASTHST3genetic
27708008
CYC2_YEASTCYC2genetic
27708008
LIPA_YEASTLIP5genetic
27708008
FABD_YEASTMCT1genetic
27708008
MRS2_YEASTMRS2genetic
27708008
MNE1_YEASTMNE1genetic
27708008
MRX4_YEASTYPL168Wgenetic
27708008
COX10_YEASTCOX10genetic
27708008
NEW1_YEASTNEW1genetic
27708008
FUMH_YEASTFUM1genetic
27708008
EAF3_YEASTEAF3genetic
27708008
MSS18_YEASTMSS18genetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VID28_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226, AND MASSSPECTROMETRY.

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