| UniProt ID | SDHA_YEAST | |
|---|---|---|
| UniProt AC | Q00711 | |
| Protein Name | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | |
| Gene Name | SDH1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 640 | |
| Subcellular Localization |
Mitochondrion inner membrane Peripheral membrane protein Matrix side . |
|
| Protein Description | Catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4.. | |
| Protein Sequence | MLSLKKSALSKLTLLRNTRTFTSSALVRQTQGSVNGSASRSADGKYHIIDHEYDCVVIGAGGAGLRAAFGLAEAGYKTACISKLFPTRSHTVAAQGGINAALGNMHKDNWKWHMYDTVKGSDWLGDQDSIHYMTREAPKSIIELEHYGVPFSRTENGKIYQRAFGGQTKEYGKGAQAYRTCAVADRTGHALLHTLYGQALRHDTHFFIEYFALDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTIIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLQDLEFVQFHPSGIYGSGCLITEGARGEGGFLVNSEGERFMERYAPTAKDLACRDVVSRAITMEIREGRGVGKKKDHMYLQLSHLPPEVLKERLPGISETAAIFAGVDVTKEPIPIIPTVHYNMGGIPTKWNGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVAHTVADTLQPGLPHKPLPSDLGKESIANLDKLRNANGSRSTAEIRMNMKQTMQKDVSVFRTQSSLDEGVRNITAVEKTFDDVKTTDRSMIWNSDLVETLELQNLLTCASQTAVSAANRKESRGAHAREDYPNRDDEHWMKHTLSWQKDVAAPVTLKYRRVIDHTLDEKECPSVPPTVRAY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MLSLKKSALSKLTL -CCCCCHHHHHHHHH | 28152593 | ||
| 10 | Phosphorylation | SLKKSALSKLTLLRN CCCHHHHHHHHHHHC | 28152593 | ||
| 30 | Phosphorylation | SSALVRQTQGSVNGS CHHHHEECCCCCCCC | 22369663 | ||
| 33 | Phosphorylation | LVRQTQGSVNGSASR HHEECCCCCCCCCCC | 22369663 | ||
| 37 | Phosphorylation | TQGSVNGSASRSADG CCCCCCCCCCCCCCC | 22369663 | ||
| 39 | Phosphorylation | GSVNGSASRSADGKY CCCCCCCCCCCCCCE | 22369663 | ||
| 90 | Tele-8alpha-FAD histidine | KLFPTRSHTVAAQGG HHCCCCCHHHHHCCC | - | ||
| 90 | Other | KLFPTRSHTVAAQGG HHCCCCCHHHHHCCC | - | ||
| 111 | Acetylation | NMHKDNWKWHMYDTV CCCCCCCEEEEEEEC | 24489116 | ||
| 129 | Phosphorylation | DWLGDQDSIHYMTRE CCCCCCCCEEEECCC | 28889911 | ||
| 139 | Acetylation | YMTREAPKSIIELEH EECCCCCCCEEEEEE | 24489116 | ||
| 243 | Phosphorylation | HRFRAHKTIIATGGY EEEEECCEEEEECCC | 22369663 | ||
| 247 | Phosphorylation | AHKTIIATGGYGRAY ECCEEEEECCCCEEE | 22369663 | ||
| 250 | Phosphorylation | TIIATGGYGRAYFSC EEEEECCCCEEEEEE | 22369663 | ||
| 449 | Phosphorylation | ANRLGANSLLDLVVF CCCCCCCHHHHHHHH | 22369663 | ||
| 491 | Acetylation | ESIANLDKLRNANGS HHHHCHHHHHCCCCC | 24489116 | ||
| 514 | Acetylation | NMKQTMQKDVSVFRT HHHHHHHCCHHHHCC | 24489116 | ||
| 523 | Phosphorylation | VSVFRTQSSLDEGVR HHHHCCCCCHHHHHH | 27214570 | ||
| 537 | Acetylation | RNITAVEKTFDDVKT HHEEEEEECCCCCCC | 24489116 | ||
| 537 | 2-Hydroxyisobutyrylation | RNITAVEKTFDDVKT HHEEEEEECCCCCCC | - | ||
| 614 | Phosphorylation | KDVAAPVTLKYRRVI CCCCCCEEEEEEEHH | 27214570 | ||
| 616 | Acetylation | VAAPVTLKYRRVIDH CCCCEEEEEEEHHCC | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SDHA_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SDHA_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SDHA_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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