| UniProt ID | VPS8_YEAST | |
|---|---|---|
| UniProt AC | P39702 | |
| Protein Name | Vacuolar protein sorting-associated protein 8 | |
| Gene Name | VPS8 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1274 | |
| Subcellular Localization | Golgi apparatus, Golgi stack. Associated with the late-Golgi membranes. | |
| Protein Description | Required for localization and recycling of the CPY sorting receptor (VPS10) to the late-Golgi compartment. Involved in the retention of proteins to the late-Golgi. Plays an integral role in the complex vacuolar protein sorting process.. | |
| Protein Sequence | MEQNGLDHDSRSSIDTTINDTQKTFLEFRSYTQLSEKLASSSSYTAPPLNEDGPKGVASAVSQGSESVVSWTTLTHVYSILGAYGGPTCLYPTATYFLMGTSKGCVLIFNYNEHLQTILVPTLSEDPSIHSIRSPVKSIVICSDGTHVAASYETGNICIWNLNVGYRVKPTSEPTNGMTPTPALPAVLHIDDHVNKEITGLDFFGARHTALIVSDRTGKVSLYNGYRRGFWQLVYNSKKILDVNSSKEKLIRSKLSPLISREKISTNLLSVLTTTHFALILLSPHVSLMFQETVEPSVQNSLVVNSSISWTQNCSRVAYSVNNKISVISISSSDFNVQSASHSPEFAESILSIQWIDQLLLGVLTISHQFLVLHPQHDFKILLRLDFLIHDLMIPPNKYFVISRRSFYLLTNYSFKIGKFVSWSDITLRHILKGDYLGALEFIESLLQPYCPLANLLKLDNNTEERTKQLMEPFYNLSLAALRFLIKKDNADYNRVYQLLMVVVRVLQQSSKKLDSIPSLDVFLEQGLEFFELKDNAVYFEVVANIVAQGSVTSISPVLFRSIIDYYAKEENLKVIEDLIIMLNPTTLDVDLAVKLCQKYNLFDLLIYIWNKIFDDYQTPVVDLIYRISNQSEKCVIFNGPQVPPETTIFDYVTYILTGRQYPQNLSISPSDKCSKIQRELSAFIFSGFSIKWPSNSNHKLYICENPEEEPAFPYFHLLLKSNPSRFLAMLNEVFEASLFNDDNDMVASVGEAELVSRQYVIDLLLDAMKDTGNSDNIRVLVAIFIATSISKYPQFIKVSNQALDCVVNTICSSRVQGIYEISQIALESLLPYYHSRTTENFILELKEKNFNKVLFHIYKSENKYASALSLILETKDIEKEYNTDIVSITDYILKKCPPGSLECGKVTEVIETNFDLLLSRIGIEKCVTIFSDFDYNLHQEILEVKNEETQQKYLDKLFSTPNINNKVDKRLRNLHIELNCKYKSKREMILWLNGTVLSNAESLQILDLLNQDSNFEAAAIIHERLESFNLAVRDLLSFIEQCLNEGKTNISTLLESLRRAFDDCNSAGTEKKSCWILLITFLITLYGKYPSHDERKDLCNKLLQEAFLGLVRSKSSSQKDSGGEFWEIMSSVLEHQDVILMKVQDLKQLLLNVFNTYKLERSLSELIQKIIEDSSQDLVQQYRKFLSEGWSIHTDDCEICGKKIWGAGLDPLLFLAWENVQRHQDMISVDLKTPLVIFKCHHGFHQTCLENLAQKPDEYSCLICQTESNPKIV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MEQNGLDH -------CCCCCCCC | 48.88 | 22814378 | |
| 10 | Phosphorylation | QNGLDHDSRSSIDTT CCCCCCCCCCCCCCC | 30.55 | 28889911 | |
| 12 | Phosphorylation | GLDHDSRSSIDTTIN CCCCCCCCCCCCCCC | 35.28 | 28889911 | |
| 13 | Phosphorylation | LDHDSRSSIDTTIND CCCCCCCCCCCCCCH | 24.31 | 28889911 | |
| 30 | Phosphorylation | KTFLEFRSYTQLSEK HHHHHHHHHHHHHHH | 37.54 | 27017623 | |
| 37 | Ubiquitination | SYTQLSEKLASSSSY HHHHHHHHHHCCCCC | 46.08 | 23749301 | |
| 40 | Phosphorylation | QLSEKLASSSSYTAP HHHHHHHCCCCCCCC | 40.98 | 27017623 | |
| 497 | Phosphorylation | NADYNRVYQLLMVVV CCCHHHHHHHHHHHH | 7.10 | 28889911 | |
| 510 | Phosphorylation | VVRVLQQSSKKLDSI HHHHHHHCCCCCCCC | 31.03 | 24909858 | |
| 511 | Phosphorylation | VRVLQQSSKKLDSIP HHHHHHCCCCCCCCC | 29.49 | 24909858 | |
| 662 | Phosphorylation | YILTGRQYPQNLSIS HHHCCCCCCCCCCCC | 12.86 | 28889911 | |
| 1176 | Phosphorylation | QKIIEDSSQDLVQQY HHHHHCCCHHHHHHH | 39.78 | 27214570 | |
| 1234 | Phosphorylation | MISVDLKTPLVIFKC CCCCCCCCCEEEEEC | 29.20 | 21126336 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VPS8_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VPS8_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VPS8_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-662, AND MASSSPECTROMETRY. | |
