TAF7_YEAST - dbPTM
TAF7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TAF7_YEAST
UniProt AC Q05021
Protein Name Transcription initiation factor TFIID subunit 7
Gene Name TAF7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 590
Subcellular Localization Nucleus .
Protein Description Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. TAF7 is responsible for the recruitment of BDF1 to TATA element containing promoters..
Protein Sequence MAVIRIKKPRGPGEKDQPLEGEPKLKRIRIKTKVTDEDIKPKPKLKINLKKKKESADGKEKKNSLKLKLNLKKNEEPVKKIHKAPKLRLKPIRIPGEAYDSEASDIEDDPLIESGVILRILPDIQLEFVKNSLESGDYSGISIKWKNERHAVVTINDVMYGAILVDLPTVIEVNKSVDRKNLLKTFDVSQMLLCIRPIQEEEEVYALEAPDTEDLVVKHFEGIEDEIWENKETFLKGYNGAPLSDMEAKHLKEIALKGYDYKHGISPPLYNVRNRRFRRKMDPNEIDYVEKVVDMLLKQDKQAEEVSYDLVDKSELQARQERVSSWENFKEEPGEPLSRPALKKEEIHTIASAVGKQGAEEEGEEGMEEEEEEDLDLGAAFESEEEGSGAEGDKEQQQEEVGDEVDQDTGGEDDDDDDDGDIEAAGGESESDDEKDENRQHTELLADELNELETTLAHTKHKLSKATNPLLKSRFIDSIKKLEKEAELKRKQLQQTEDSVQKQHQHRSDAETANNVEEEEEEEEEEEEEDEVDEDEEDDEENDEDEDNVHEREHIQENKVVRELDEAPAEETLDQNDLDMMMLFGAEGDE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15AcetylationKPRGPGEKDQPLEGE
CCCCCCCCCCCCCCC		68.5224489116
64PhosphorylationDGKEKKNSLKLKLNL
CCHHHHHHHHHHHHC		35.4428889911
79AcetylationKKNEEPVKKIHKAPK
CCCCCCHHHHHCCCC		57.6425381059
99PhosphorylationIRIPGEAYDSEASDI
CCCCCCCCCCCCCCC		18.7225533186
101PhosphorylationIPGEAYDSEASDIED
CCCCCCCCCCCCCCC		23.5325533186
104PhosphorylationEAYDSEASDIEDDPL
CCCCCCCCCCCCCCC		34.7621082442
114PhosphorylationEDDPLIESGVILRIL
CCCCCCCCCCCEEEC		31.2223607784
132PhosphorylationQLEFVKNSLESGDYS
EEHHHHHHHHCCCCC		28.0028889911
135PhosphorylationFVKNSLESGDYSGIS
HHHHHHHCCCCCCEE		42.1128889911
257AcetylationHLKEIALKGYDYKHG
HHHHHHHCCCCCCCC		46.5325381059
314PhosphorylationSYDLVDKSELQARQE
CCCCCCHHHHHHHHH		38.7924961812
324PhosphorylationQARQERVSSWENFKE
HHHHHHHHHHHHHCC		35.6329136822
325PhosphorylationARQERVSSWENFKEE
HHHHHHHHHHHHCCC		35.2422369663
383PhosphorylationDLGAAFESEEEGSGA
CHHHHHCCCCCCCCC		43.8028889911
388PhosphorylationFESEEEGSGAEGDKE
HCCCCCCCCCCCCHH		37.8028889911
499PhosphorylationQLQQTEDSVQKQHQH
HHHHHHHHHHHHHHH		21.8830377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TAF7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TAF7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TAF7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TBP_YEASTSPT15physical
12052880
TBP_YEASTSPT15physical
10788514
TAF1_YEASTTAF1physical
12052880
TAF1_YEASTTAF1physical
10788514
TAF2_YEASTTAF2physical
12052880
TAF9_YEASTTAF9physical
12052880
TAF13_YEASTTAF13physical
12052880
TAF10_YEASTTAF10physical
12052880
TAF14_YEASTTAF14physical
12052880
TAF11_YEASTTAF11physical
12052880
TAF3_YEASTTAF3physical
12052880
TAF4_YEASTTAF4physical
12052880
TAF6_YEASTTAF6physical
12052880
TAF12_YEASTTAF12physical
12052880
TAF8_YEASTTAF8physical
12052880
CRZ1_YEASTCRZ1physical
12052880
MCM1_YEASTMCM1physical
12052880
RRP3_YEASTRRP3physical
12052880
RTG3_YEASTRTG3physical
12052880
SWI6_YEASTSWI6physical
12052880
TAF5_YEASTTAF5physical
12052880
TRA1_YEASTTRA1physical
12052880
TAF6_YEASTTAF6physical
12582245
ASF1_YEASTASF1physical
12093919
BDF1_YEASTBDF1physical
10783167
TAF5_YEASTTAF5physical
12215531
TAF3_YEASTTAF3physical
12215531
TAF10_YEASTTAF10physical
12215531
NDC1_YEASTNDC1physical
16554755
TAF9_YEASTTAF9physical
16554755
TAF3_YEASTTAF3physical
16554755
SERB_YEASTSER2genetic
17314980
UBX1_YEASTSHP1genetic
17314980
RTG3_YEASTRTG3genetic
17314980
CIK1_YEASTCIK1genetic
17314980
PFD5_YEASTGIM5genetic
17314980
MUM2_YEASTMUM2genetic
17314980
UBC7_YEASTUBC7genetic
17314980
MED20_YEASTSRB2genetic
17314980
UBP6_YEASTUBP6genetic
17314980
MED5_YEASTNUT1genetic
17314980
SLX5_YEASTSLX5genetic
17314980
DOA1_YEASTDOA1genetic
17314980
SDC1_YEASTSDC1genetic
17314980
SWI3_YEASTSWI3genetic
17314980
MMS2_YEASTMMS2genetic
17314980
MAD1_YEASTMAD1genetic
17314980
ISW1_YEASTISW1genetic
17314980
RAD16_YEASTRAD16genetic
17314980
SIZ1_YEASTSIZ1genetic
17314980
SRS2_YEASTSRS2genetic
17314980
RE104_YEASTREC104genetic
17314980
APC9_YEASTAPC9genetic
17314980
RSC2_YEASTRSC2genetic
17314980
BDF1_YEASTBDF1physical
18719252
BDF2_YEASTBDF2physical
18719252
AIM4_YEASTAIM4genetic
20093466
AGP1_YEASTAGP1genetic
20093466
THRC_YEASTTHR4genetic
20093466
NHP10_YEASTNHP10genetic
20093466
PAA1_YEASTPAA1genetic
20093466
UBP3_YEASTUBP3genetic
20093466
PHB2_YEASTPHB2genetic
20093466
YOR1_YEASTYOR1genetic
20093466
RSSA2_YEASTRPS0Bgenetic
20093466
UPS1_YEASTUPS1genetic
20093466
SST2_YEASTSST2genetic
20093466
BRE5_YEASTBRE5genetic
20093466
PALA_YEASTRIM20genetic
20093466
NEW1_YEASTNEW1genetic
20093466
VPS53_YEASTVPS53physical
22875988
END3_YEASTEND3physical
22875988
NCA2_YEASTNCA2physical
22875988
CDC10_YEASTCDC10genetic
27708008
SEC7_YEASTSEC7genetic
27708008
CDC1_YEASTCDC1genetic
27708008
KCY_YEASTURA6genetic
27708008
DMA2_YEASTDMA2genetic
27708008
TAF5_YEASTTAF5genetic
27708008
TFB1_YEASTTFB1genetic
27708008
TAF1_YEASTTAF1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
MCM10_YEASTMCM10genetic
27708008
KTHY_YEASTCDC8genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
SSL1_YEASTSSL1genetic
27708008
TAF11_YEASTTAF11genetic
27708008
TAF13_YEASTTAF13genetic
27708008
TAF4_YEASTTAF4genetic
27708008
HRP1_YEASTHRP1genetic
27708008
MED4_YEASTMED4genetic
27708008
DYR_YEASTDFR1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
ARP7_YEASTARP7genetic
27708008
SRP54_YEASTSRP54genetic
27708008
AIM4_YEASTAIM4genetic
27708008
SLX5_YEASTSLX5genetic
27708008
LSM6_YEASTLSM6genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
CSK2B_YEASTCKB1genetic
27708008
MED5_YEASTNUT1genetic
27708008
GSH1_YEASTGSH1genetic
27708008
ASF1_YEASTASF1genetic
27708008
LSM1_YEASTLSM1genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
LSM7_YEASTLSM7genetic
27708008
DCAM_YEASTSPE2genetic
27708008
CSK2C_YEASTCKB2genetic
27708008
DIA2_YEASTDIA2genetic
27708008
PMA2_YEASTPMA2genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
SRO7_YEASTSRO7genetic
27708008
THP3_YEASTTHP3genetic
27708008
SPEE_YEASTSPE3genetic
27708008
SUE1_YEASTSUE1genetic
27708008
KLH12_HUMANKLHL12physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TAF7_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-99; SER-101; SER-104 ANDSER-324, AND MASS SPECTROMETRY.

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