NCA2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCA2_YEAST
• UniProt AC: Q12374
• Protein Name: Nuclear control of ATPase protein 2
• Gene Name: NCA2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 616
• Subcellular Localization: Mitochondrion membrane ; Multi-pass membrane protein .
• Protein Description: Involved in the mitochondrial expression of subunits 6 and 8 of the F0-F1 ATP synthase..
• Protein Sequence: MIINRRILKSFEEISHSLEESLREVAFDSQQQLIQDVREENEELSRLQDQLQLIRSIVEKICISIKTDNIDSYCSVPFDLLYNICKDIADPSSFEDGDLQYLVSQAIFEYIILLCYYSVTNECVQGLPAVYEAEQYYKTVSDSILKSFLYCLQNSVSTIRLLSQTVLKDVNKKKLSHQKWSLKALSVDLLEKIRPRINKFMVIRNFRFVGLPKKPIEIASLVSDIPRGIVHERLDMVTQSSKYYTIKLGQLITEFDQQPEENGMFTEVHLPNYERRLKSLQDFFGLAMSDSNLLDVIRCSAKFHKDHPLRRFTKPSILTRYWPSILLCLLYGPSSVMSLWNSRYFIQDFIKTNVVDFAKGLILNWLWAPLKQVWSTVKHDEGSAISVTSQETLNSDMDSLTRMIVSFVVDNSDSTSNSPIDPILLSTKVEHGDLTEFMEIYETQLHHPIKNIATGGLVRSLLIQLQKTKVDGSMALNGIDKMLKSQQLVFGVVALSPALVILYSSIVALKRFVKLGNVWSNEKRYREQISISLNNVERVLNYSKQGADADEEHLNQGLLVIEVSNLYKLGSFLIPRSRKKEWFRDVEELVDTNLDSGAHINVVNRIYHVYGRFLIH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	LREVAFDSQQQLIQD HHHHHHHHHHHHHHH	24.36	29136822

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NCA2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCA2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCA2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SWF1_YEAST	SWF1	genetic	20093466
SSD1_YEAST	SSD1	genetic	20093466
RL22A_YEAST	RPL22A	genetic	20093466
VRP1_YEAST	VRP1	genetic	20093466
ELP3_YEAST	ELP3	genetic	20093466
HSP71_YEAST	SSA1	physical	22940862
LAM4_YEAST	YHR080C	physical	22875988
NTR2_YEAST	NTR2	physical	22875988
NKP2_YEAST	NKP2	physical	22875988
KEL2_YEAST	KEL2	physical	22875988
SLX5_YEAST	SLX5	genetic	29674565
VAM7_YEAST	VAM7	genetic	29674565
LPLA_YEAST	AIM22	genetic	29674565
ASF1_YEAST	ASF1	genetic	29674565
SIN3_YEAST	SIN3	genetic	29674565
CHL1_YEAST	CHL1	genetic	29674565
GGPPS_YEAST	BTS1	genetic	29674565

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29, AND MASSSPECTROMETRY.
PubMed: 18407956