RL22A_YEAST - dbPTM
RL22A_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RL22A_YEAST
UniProt AC P05749
Protein Name 60S ribosomal protein L22-A {ECO:0000303|PubMed:9559554}
Gene Name RPL22A {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 121
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MAPNTSRKQKIAKTFTVDVSSPTENGVFDPASYAKYLIDHIKVEGAVGNLGNAVTVTEDGTVVTVVSTAKFSGKYLKYLTKKYLKKNQLRDWIRFVSTKTNEYRLAFYQVTPEEDEEEDEE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13SuccinylationSRKQKIAKTFTVDVS
CHHHHEEEEEEEECC		47.8723954790
13AcetylationSRKQKIAKTFTVDVS
CHHHHEEEEEEEECC		47.8724489116
14PhosphorylationRKQKIAKTFTVDVSS
HHHHEEEEEEEECCC		18.6022369663
16PhosphorylationQKIAKTFTVDVSSPT
HHEEEEEEEECCCCC		22.4922369663
20PhosphorylationKTFTVDVSSPTENGV
EEEEEECCCCCCCCC		26.5722369663
21PhosphorylationTFTVDVSSPTENGVF
EEEEECCCCCCCCCC		35.3722369663
23PhosphorylationTVDVSSPTENGVFDP
EEECCCCCCCCCCCH		43.9922369663
32PhosphorylationNGVFDPASYAKYLID
CCCCCHHHHHHHHHH		30.8922369663
33PhosphorylationGVFDPASYAKYLIDH
CCCCHHHHHHHHHHH		14.8222369663
75PhosphorylationTAKFSGKYLKYLTKK
ECCCCHHHHHHHHHH		16.3819823750
772-HydroxyisobutyrylationKFSGKYLKYLTKKYL
CCCHHHHHHHHHHHH		34.81-
77AcetylationKFSGKYLKYLTKKYL
CCCHHHHHHHHHHHH		34.8124489116
78PhosphorylationFSGKYLKYLTKKYLK
CCHHHHHHHHHHHHH		19.6019823750
80PhosphorylationGKYLKYLTKKYLKKN
HHHHHHHHHHHHHHC		23.5419823750
98PhosphorylationDWIRFVSTKTNEYRL
HHHHHHHCCCCEEEE		36.2630377154
99UbiquitinationWIRFVSTKTNEYRLA
HHHHHHCCCCEEEEE		41.6723749301
99AcetylationWIRFVSTKTNEYRLA
HHHHHHCCCCEEEEE		41.6724489116
992-HydroxyisobutyrylationWIRFVSTKTNEYRLA
HHHHHHCCCCEEEEE		41.67-
99SuccinylationWIRFVSTKTNEYRLA
HHHHHHCCCCEEEEE		41.6723954790
100PhosphorylationIRFVSTKTNEYRLAF
HHHHHCCCCEEEEEE		33.1130377154
111PhosphorylationRLAFYQVTPEEDEEE
EEEEEEECCCCCCHH		14.9525533186
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RL22A_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RL22A_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RL22A_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CCZ1_YEASTCCZ1genetic
20093466
YB75_YEASTYBR225Wgenetic
20093466
VBA2_YEASTVBA2genetic
20093466
SPS22_YEASTSPS22genetic
20093466
ILV6_YEASTILV6genetic
20093466
YD129_YEASTYDL129Wgenetic
20093466
MRK1_YEASTMRK1genetic
20093466
PUS9_YEASTPUS9genetic
20093466
RRP8_YEASTRRP8genetic
20093466
NUM1_YEASTNUM1genetic
20093466
SSD1_YEASTSSD1genetic
20093466
THI74_YEASTTHI74genetic
20093466
RL22B_YEASTRPL22Bgenetic
20093466
HAP2_YEASTHAP2genetic
20093466
LEUC_YEASTLEU1genetic
20093466
MAL12_YEASTMAL12genetic
20093466
YSC84_YEASTYSC84genetic
20093466
INM1_YEASTINM1genetic
20093466
SDS3_YEASTSDS3genetic
20093466
YJV3_YEASTYJL213Wgenetic
20093466
SAC1_YEASTSAC1genetic
20093466
EF1G2_YEASTTEF4genetic
20093466
TOF2_YEASTTOF2genetic
20093466
DS1P2_YEASTYSR3genetic
20093466
ATG39_YEASTYLR312Cgenetic
20093466
RL38_YEASTRPL38genetic
20093466
BUL2_YEASTBUL2genetic
20093466
SCS7_YEASTSCS7genetic
20093466
WHI5_YEASTWHI5genetic
20093466
TBCC_YEASTCIN2genetic
20093466
MKK2_YEASTMKK2genetic
20093466
SUR1_YEASTSUR1genetic
20093466
MED1_YEASTMED1genetic
20093466
YP097_YEASTYPR097Wgenetic
20093466
NCA2_YEASTNCA2genetic
20093466
SIR2_YEASTSIR2genetic
21902802
RL22B_YEASTRPL22Bgenetic
22377630
MKK2_YEASTMKK2genetic
22282571
RL22B_YEASTRPL22Bphysical
27097027
ILV6_YEASTILV6genetic
27708008
SAC3_YEASTSAC3genetic
27708008
SGF29_YEASTSGF29genetic
27708008
POF1_YEASTPOF1genetic
27708008
MRK1_YEASTMRK1genetic
27708008
PP2A1_YEASTPPH21genetic
27708008
RRP8_YEASTRRP8genetic
27708008
NUM1_YEASTNUM1genetic
27708008
RL22B_YEASTRPL22Bgenetic
27708008
UBP6_YEASTUBP6genetic
27708008
MAL12_YEASTMAL12genetic
27708008
EF1G2_YEASTTEF4genetic
27708008
RL38_YEASTRPL38genetic
27708008
PABC_YEASTABZ2genetic
27708008
EOS1_YEASTEOS1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
RL22B_YEASTRPL22Bgenetic
27811238
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RL22A_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; THR-23; SER-32 ANDTHR-111, AND MASS SPECTROMETRY.

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