dbPTM

PUS9_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PUS9_YEAST
UniProt AC	Q12069
Protein Name	tRNA pseudouridine(32) synthase, mitochondrial
Gene Name	PUS9
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	462
Subcellular Localization	Mitochondrion .
Protein Description	Responsible for synthesis of pseudouridine from uracil-32 in mitochondrial transfer RNAs..
Protein Sequence	MQRNNRLRNLFTVPVIMARQLKRNALSAGLAFAGNATSNEFDEHLQNEVEREREIQKKKKIKRTQSKKSPDLINKSTFQSRTIGSKKEKHRQLDPEYEIVIDGPLRKIKPYHFTYRTFCKERWRDKKLVDVFISEFRDRESEYYKRTIENGDVHINDETADLSTVIRNGDLITHQVHRHEPPVTSRPIKVIFEDDNIMVIDKPSGIPVHPTGRYRFNTITKMLQNNLGFVVNPCNRLDRLTSGLMFLAKTPKGADNIGDQLKAREVTKEYVAKVVGEFPETEVIVEKPLKLIEPRLALNAVCQMDEKGAKHAKTVFNRISYDGKTSIVKCKPLTGRSHQIRVHLQYLGHPIANDPIYSNDEVWGNNLGKGGQADFDIVITKLDEIGKRKPAKSWFHSNGGYGEVLRQEKCSICESDLYTDPGPNDLDLWLHAYLYESTETEEGTEKKKWCYKTEYPEWALRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
68	Acetylation	IKRTQSKKSPDLINK HCCCCCCCCCCCCCH	72.90	25381059
69	Phosphorylation	KRTQSKKSPDLINKS CCCCCCCCCCCCCHH	27.64	17563356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PUS9_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PUS9_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PUS9_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRS4_YEAST	RPT2	physical	16554755
RPN10_YEAST	RPN10	physical	16554755
MGR1_YEAST	MGR1	genetic	20093466
RIM1_YEAST	RIM1	genetic	20093466
ATG15_YEAST	ATG15	genetic	20093466
TMS1_YEAST	TMS1	genetic	20093466
YD124_YEAST	YDR124W	genetic	20093466
EMI1_YEAST	EMI1	genetic	20093466
YGY5_YEAST	YGL235W	genetic	20093466
ASK10_YEAST	ASK10	genetic	20093466
NPR3_YEAST	NPR3	genetic	20093466
OPI1_YEAST	OPI1	genetic	20093466
PTK2_YEAST	PTK2	genetic	20093466
RL22A_YEAST	RPL22A	genetic	20093466
LIPB_YEAST	LIP2	genetic	20093466
ATP10_YEAST	ATP10	genetic	20093466
COX5A_YEAST	COX5A	genetic	20093466
ATP23_YEAST	ATP23	genetic	20093466
NIP80_YEAST	NIP100	genetic	20093466

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PUS9_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69, AND MASSSPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69, AND MASSSPECTROMETRY.	17563356 [Abstract]