| UniProt ID | NPR3_YEAST | |
|---|---|---|
| UniProt AC | P38742 | |
| Protein Name | Nitrogen permease regulator 3 | |
| Gene Name | NPR3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1146 | |
| Subcellular Localization |
Vacuole membrane Peripheral membrane protein . |
|
| Protein Description | Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.. | |
| Protein Sequence | MDECLPNSCLLGVHLVISTHSGPQIVYHYPPSNTAFLTNNPTKHQHLYGNHANLNKNTSTNKEEKLFNSGSTKTASQIALNESAKSYNTAITPSMTNTNTNNVTLPPTRSHANTVGSQSSIPAATNGVGYRKTDIEDTSRTFQYQETESETSSSGLSDSELSTDYLDISSDSFSISSSLSSSSLSSSPSSSSSSSPPQDGLSRTNSSFQSTDSMSPTSPQMIMENDSISVAESYLDSGTNNKSRAASKRSQNFFHKLSTKKSTDSKTHSPVRKLKSKPSQSTKKGNKLLKNTSNETDGNAFTGSCSISSKKSLSSTGEHNQELRNSSLNDTPGQSPHHYHHRYHHYHKNAATSQRNSHTQYDVEEEDMEVSAMLQDGKISMNEIFFEEENFQDINKILEFDNDFVAEFCSPEREMCNTRFEFTVDNFCFLGLPIHVDSQGRWRKSKHKNKTRSKRSSSTTTNISRKKSIASKISSLSENTLKKVNSGEADTVYDSNIGHEASTDTPNLRINTDVSGNEFEREKEDLGKNMNMFHVCFVMNPHLIEYNKRIDDMYQFVVTRLSLLLRYVQSKTSYISSECHIILKEKERVLKHSKTYQSIRGAGNKGKYLYQRILAKSSLARALTECVDKIQRNEIACLEINDDKVISLQIPIQNEFEKMPNFKLQPVLRGSYLTSILNMKFLEKSSLRIESQNRQNDQAQFSDTNNNIYRFGNNINSTGHCGAANVDDGDDNESNYYCDDNDDLLNYALLLLDEPNNIISSLETFSYQDDIGTIILKHLVRNIQPNIPLRSYRYLITDLLDNPSSLDDLTTETNSLESSILRSCALHLMYWRHARIVIPLSSKYTYIVSPLAPIQGYTIDDYKSTSQNDGNVKKMDDRENNKSGSDRVPLIYQNSMLFRSKFPSLPSLPIFLSLLSTDKPQAYSNIIPSREHKPVYLNALAWLIQYGYVTQLLTFINIRVDKHIKMAVDEDLEKEGFRKTNTARRPSMDYKKTDKKLDDEDGQSRDANASEACSGKNEGMQSNDNNKDVDEKDNENDSRVDDRDDNEIAIADEEEILHFEYDDPEMQHDYTIILEPERATAIEKRWLYRCIYGQPSDIQILFNKLLKYFNGKVPMELVIIKEEISRHDLKKLLNALDKYLIEIHHW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 74 | Phosphorylation | FNSGSTKTASQIALN HCCCCCCCHHHHHHH | 31.46 | 22369663 | |
| 76 | Phosphorylation | SGSTKTASQIALNES CCCCCCHHHHHHHHC | 27.61 | 22369663 | |
| 110 | Phosphorylation | VTLPPTRSHANTVGS EECCCCCCCCCCCCC | 29.45 | 22369663 | |
| 114 | Phosphorylation | PTRSHANTVGSQSSI CCCCCCCCCCCCCCC | 27.33 | 22369663 | |
| 117 | Phosphorylation | SHANTVGSQSSIPAA CCCCCCCCCCCCCCC | 23.66 | 22369663 | |
| 119 | Phosphorylation | ANTVGSQSSIPAATN CCCCCCCCCCCCCCC | 31.75 | 22369663 | |
| 120 | Phosphorylation | NTVGSQSSIPAATNG CCCCCCCCCCCCCCC | 25.59 | 22369663 | |
| 125 | Phosphorylation | QSSIPAATNGVGYRK CCCCCCCCCCCCCEE | 34.31 | 22369663 | |
| 130 | Phosphorylation | AATNGVGYRKTDIED CCCCCCCCEECCHHH | 13.41 | 22369663 | |
| 250 | Phosphorylation | SRAASKRSQNFFHKL HHHHHHHHHHHHHHH | 32.96 | 23749301 | |
| 258 | Phosphorylation | QNFFHKLSTKKSTDS HHHHHHHHCCCCCCC | 42.88 | 19823750 | |
| 259 | Phosphorylation | NFFHKLSTKKSTDSK HHHHHHHCCCCCCCC | 53.58 | 19823750 | |
| 262 | Phosphorylation | HKLSTKKSTDSKTHS HHHHCCCCCCCCCCC | 38.72 | 19823750 | |
| 263 | Phosphorylation | KLSTKKSTDSKTHSP HHHCCCCCCCCCCCC | 53.85 | 19823750 | |
| 265 | Phosphorylation | STKKSTDSKTHSPVR HCCCCCCCCCCCCCH | 39.27 | 19823750 | |
| 267 | Phosphorylation | KKSTDSKTHSPVRKL CCCCCCCCCCCCHHH | 31.38 | 19823750 | |
| 269 | Phosphorylation | STDSKTHSPVRKLKS CCCCCCCCCCHHHCC | 30.26 | 19823750 | |
| 281 | Phosphorylation | LKSKPSQSTKKGNKL HCCCCCCCCHHHCEE | 46.67 | 21551504 | |
| 292 | Phosphorylation | GNKLLKNTSNETDGN HCEECCCCCCCCCCC | 31.20 | 30377154 | |
| 293 | Phosphorylation | NKLLKNTSNETDGNA CEECCCCCCCCCCCC | 41.90 | 23749301 | |
| 302 | Phosphorylation | ETDGNAFTGSCSISS CCCCCCCCCCCEECC | 26.27 | 27717283 | |
| 304 | Phosphorylation | DGNAFTGSCSISSKK CCCCCCCCCEECCCC | 11.13 | 20377248 | |
| 306 | Phosphorylation | NAFTGSCSISSKKSL CCCCCCCEECCCCCC | 27.48 | 20377248 | |
| 308 | Phosphorylation | FTGSCSISSKKSLSS CCCCCEECCCCCCCC | 21.58 | 20377248 | |
| 309 | Phosphorylation | TGSCSISSKKSLSST CCCCEECCCCCCCCC | 42.29 | 20377248 | |
| 312 | Phosphorylation | CSISSKKSLSSTGEH CEECCCCCCCCCCCC | 36.90 | 22369663 | |
| 314 | Phosphorylation | ISSKKSLSSTGEHNQ ECCCCCCCCCCCCCH | 32.70 | 22369663 | |
| 315 | Phosphorylation | SSKKSLSSTGEHNQE CCCCCCCCCCCCCHH | 45.80 | 22369663 | |
| 316 | Phosphorylation | SKKSLSSTGEHNQEL CCCCCCCCCCCCHHH | 43.12 | 22369663 | |
| 335 | Phosphorylation | LNDTPGQSPHHYHHR CCCCCCCCCCCCHHC | 31.92 | 28889911 | |
| 371 | Phosphorylation | EEEDMEVSAMLQDGK CHHHHHHHHHHCCCC | 8.48 | 24961812 | |
| 456 | Phosphorylation | NKTRSKRSSSTTTNI CCCCCCCCCCCCCCH | 32.17 | 19823750 | |
| 457 | Phosphorylation | KTRSKRSSSTTTNIS CCCCCCCCCCCCCHH | 35.42 | 27214570 | |
| 458 | Phosphorylation | TRSKRSSSTTTNISR CCCCCCCCCCCCHHH | 30.90 | 23749301 | |
| 459 | Phosphorylation | RSKRSSSTTTNISRK CCCCCCCCCCCHHHH | 39.32 | 23749301 | |
| 460 | Phosphorylation | SKRSSSTTTNISRKK CCCCCCCCCCHHHHH | 21.57 | 19823750 | |
| 461 | Phosphorylation | KRSSSTTTNISRKKS CCCCCCCCCHHHHHH | 30.55 | 19823750 | |
| 464 | Phosphorylation | SSTTTNISRKKSIAS CCCCCCHHHHHHHHH | 39.87 | 27717283 | |
| 468 | Phosphorylation | TNISRKKSIASKISS CCHHHHHHHHHHHHH | 26.82 | 21440633 | |
| 471 | Phosphorylation | SRKKSIASKISSLSE HHHHHHHHHHHHCCH | 28.93 | 21440633 | |
| 474 | Phosphorylation | KSIASKISSLSENTL HHHHHHHHHCCHHHH | 29.03 | 21440633 | |
| 475 | Phosphorylation | SIASKISSLSENTLK HHHHHHHHCCHHHHH | 39.11 | 22369663 | |
| 477 | Phosphorylation | ASKISSLSENTLKKV HHHHHHCCHHHHHHC | 30.65 | 22369663 | |
| 480 | Phosphorylation | ISSLSENTLKKVNSG HHHCCHHHHHHCCCC | 35.58 | 22369663 | |
| 486 | Phosphorylation | NTLKKVNSGEADTVY HHHHHCCCCCCCCEE | 40.78 | 22369663 | |
| 491 | Phosphorylation | VNSGEADTVYDSNIG CCCCCCCCEEECCCC | 28.19 | 22369663 | |
| 493 | Phosphorylation | SGEADTVYDSNIGHE CCCCCCEEECCCCCC | 18.75 | 22369663 | |
| 495 | Phosphorylation | EADTVYDSNIGHEAS CCCCEEECCCCCCCC | 16.80 | 22369663 | |
| 502 | Phosphorylation | SNIGHEASTDTPNLR CCCCCCCCCCCCCEE | 24.67 | 22369663 | |
| 503 | Phosphorylation | NIGHEASTDTPNLRI CCCCCCCCCCCCEEE | 51.44 | 22369663 | |
| 505 | Phosphorylation | GHEASTDTPNLRINT CCCCCCCCCCEEEEE | 17.73 | 22369663 | |
| 515 | Phosphorylation | LRINTDVSGNEFERE EEEEECCCCCCHHHH | 38.42 | 27214570 | |
| 573 | Phosphorylation | RYVQSKTSYISSECH HHHHHCCCCCCCCCE | 24.97 | 20377248 | |
| 574 | Phosphorylation | YVQSKTSYISSECHI HHHHCCCCCCCCCEE | 15.28 | 20377248 | |
| 577 | Phosphorylation | SKTSYISSECHIILK HCCCCCCCCCEEEEE | 34.38 | 20377248 | |
| 702 | Phosphorylation | QNDQAQFSDTNNNIY CCCCCCCCCCCCCEE | 31.29 | 30377154 | |
| 804 | Phosphorylation | TDLLDNPSSLDDLTT HHHHCCCCHHHHCCC | 50.19 | 28889911 | |
| 805 | Phosphorylation | DLLDNPSSLDDLTTE HHHCCCCHHHHCCCC | 36.75 | 28889911 | |
| 883 | Phosphorylation | DDRENNKSGSDRVPL CCCCCCCCCCCCCCE | 45.73 | 28889911 | |
| 885 | Phosphorylation | RENNKSGSDRVPLIY CCCCCCCCCCCCEEE | 29.36 | 28889911 | |
| 892 | Phosphorylation | SDRVPLIYQNSMLFR CCCCCEEEECCHHHH | 14.88 | 28889911 | |
| 895 | Phosphorylation | VPLIYQNSMLFRSKF CCEEEECCHHHHCCC | 11.01 | 28889911 | |
| 980 | Phosphorylation | EKEGFRKTNTARRPS HHHCCCCCCCCCCCC | 33.28 | 21440633 | |
| 982 | Phosphorylation | EGFRKTNTARRPSMD HCCCCCCCCCCCCCC | 27.11 | 21440633 | |
| 987 | Phosphorylation | TNTARRPSMDYKKTD CCCCCCCCCCCHHCC | 23.60 | 17287358 | |
| 1004 | Phosphorylation | LDDEDGQSRDANASE CCCCCCCCCCCCHHH | 37.34 | 20377248 | |
| 1010 | Phosphorylation | QSRDANASEACSGKN CCCCCCHHHHCCCCC | 26.07 | 20377248 | |
| 1014 | Phosphorylation | ANASEACSGKNEGMQ CCHHHHCCCCCCCCC | 60.91 | 22369663 | |
| 1022 | Phosphorylation | GKNEGMQSNDNNKDV CCCCCCCCCCCCCCC | 36.94 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NPR3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NPR3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NPR3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76; SER-456; SER-477;THR-480; SER-486; SER-885 AND TYR-892, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117; SER-120 ANDSER-486. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-987, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-486, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, AND MASSSPECTROMETRY. | |
