| UniProt ID | IML1_YEAST | |
|---|---|---|
| UniProt AC | P47170 | |
| Protein Name | Vacuolar membrane-associated protein IML1 | |
| Gene Name | IML1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1584 | |
| Subcellular Localization |
Vacuole membrane Peripheral membrane protein . |
|
| Protein Description | Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.. | |
| Protein Sequence | MFAKLHGKKQRPISSINSQTPRTSNTTHANSISLSSGNLIVGSNRNLRQKKEQFGSQQRASGRKLISNKENDDNVNNGGDNNYDNGERVHRHHIPGLKIKAYQAELGYHESRFSENLVMLNLVEFPDIKPGDLVELKTYHKNPSASNGDKKIYFIAKDFDGETKRRAKTSNVSILSGQLQTLLDLPSRSRIWIKLKPNKFDLQADVVEFNIKDCLLNRGDMWVLSSKLVDTCVFMDQRLAFLDSIRGTIKGIYRNGKKIVSGYIGEQTRIIFRSESARLIFLIQITDEMWNFEETGEQLFQKMVNSFFPKIFKKWKDVDTHHTITIAFAISMDLSDTSFKDLTPGESLKNSQDYFRIVVDQVSIIHWVDIMETLREEFMEIRKDLLNKQTDKGYSVANGRFSPVIKSNFLELVNFATTILTDPFKQLDLRHTTTHVMIISPGSGLFDVDYSLLRLTGKKLLSLEMTMDLICLSKAPLHIVPLFRYRDFENKLHHCVPLWLSVFFWNDHDKKSNSEWTPRCKIYDLQMMGITENELIREVDVEYLQLNKKVKSLSEFMNDYDKNAFEVKILCAGSNTKQSKKLNSKFDTVFENDVVVKARKIPATATTTHGNTKFIWRGPKVALPAIKDIQKPNVIPDLSIKTIEASFYDDCNTTNDKISTPTTSNNDNLEMNDSLVSVRSADNQNTSLALDSLKGLSKRNSLKDFTQRVITKFISNIDTSKNKKIKSTLLRDDVDNSPLGSNTPLPSSESKISGLKLQQKGLADENVISKRGNLIIKKNLSIFGLPSNEIMSGSPSSYLGSSHTRTSSKLSNMSDKAAFITEGQKSKHDDSNTYSLTQQLKHRISETWVDIKSPSIPVSSEFANELLPIRWKDVWPKYVARKYSKWRSFTTPAELPITISDFPSKDDFDRNFIFRNHSVTLNTDQEQYNQTYKDLLRDMIYMRLLTGFQICVGRQVEKIELSRESGESETVVNKYLDFNQNDAFKLYLMIDSEIHRITCSSSGIIDVERYLRKDEANLFDQVPSYIPLVKTRYESSFRDAMIDPLHVKRESLNWNQIDQVLAGYGDNLIDRKWHGFRAKYVVLPTDIPPNTYSMVINGKSETLNPEEIRVEGLRRLIGSITRSRLRTEKEKKGRKTKREEIQPEVMFYTGPLYNFINEQQTSLESSAINFKDSIFVNDNNLLNRNVELSKLAYQIQRGEDRITLVNRKWHWKKHEKCFVGSEMVNWLIRNFSDIDTREDAIKYGQKVMKEGLFVHVLNKHNFLDGHYFYQFSPEYVMDTNKLEKTNSHRSTLSDPKQMLRKASTGSSNDPSAMTPFSSVVPAISASNASVADAKEPSRPILMLSNSLVIDVDPAGKSSKQESCTVHYDRVHNPDHCFHIRLEWLTTTPKLIDDLVGNWSRLCERYGLKMIEIPWEELCTIPSVNPFHSFVEIKLAINPWEDPEFKDRELFAKSKFYYHVYLLKASGFLLDNRASKFLQNQDIEFDIMYSWGKPQFKYVQYIHHTGAYVAELRENGCLFLAPNNIYISRVNPGNIIGKIHSASSSSLDAQKVILNFKSTCLDYQKLRSIFLDAKEMWITGKIVED | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 33 | Phosphorylation | TTHANSISLSSGNLI CCCCCEEEECCCCEE | 23.24 | 19779198 | |
| 35 | Phosphorylation | HANSISLSSGNLIVG CCCEEEECCCCEEEC | 29.43 | 19779198 | |
| 69 | Ubiquitination | GRKLISNKENDDNVN CCCCCCCCCCCCCCC | 51.62 | 23749301 | |
| 392 | Ubiquitination | LLNKQTDKGYSVANG HHHCCCCCCCCCCCC | 64.24 | 23749301 | |
| 462 | Phosphorylation | LTGKKLLSLEMTMDL HHCCHHHCEEHHHHH | 32.49 | 19823750 | |
| 466 | Phosphorylation | KLLSLEMTMDLICLS HHHCEEHHHHHHHHC | 9.73 | 19823750 | |
| 473 | Phosphorylation | TMDLICLSKAPLHIV HHHHHHHCCCCEEEE | 23.51 | 19823750 | |
| 552 | Phosphorylation | QLNKKVKSLSEFMND HHHHHHHHHHHHHHH | 39.86 | 21440633 | |
| 554 | Phosphorylation | NKKVKSLSEFMNDYD HHHHHHHHHHHHHCC | 35.56 | 21440633 | |
| 604 | Phosphorylation | KARKIPATATTTHGN EEEECCCCEEECCCC | 21.12 | 27017623 | |
| 653 | Phosphorylation | SFYDDCNTTNDKIST EEECCCCCCCCCCCC | 33.05 | 28889911 | |
| 664 | Phosphorylation | KISTPTTSNNDNLEM CCCCCCCCCCCCCCC | 35.79 | 29734811 | |
| 674 | Phosphorylation | DNLEMNDSLVSVRSA CCCCCCCCEEEEEEC | 26.18 | 21551504 | |
| 680 | Phosphorylation | DSLVSVRSADNQNTS CCEEEEEECCCCCCH | 37.51 | 22369663 | |
| 686 | Phosphorylation | RSADNQNTSLALDSL EECCCCCCHHHHHHH | 18.49 | 22369663 | |
| 687 | Phosphorylation | SADNQNTSLALDSLK ECCCCCCHHHHHHHH | 21.13 | 22369663 | |
| 692 | Phosphorylation | NTSLALDSLKGLSKR CCHHHHHHHHHHHHC | 32.60 | 22369663 | |
| 701 | Phosphorylation | KGLSKRNSLKDFTQR HHHHHCCCHHHHHHH | 40.61 | 28889911 | |
| 715 | Phosphorylation | RVITKFISNIDTSKN HHHHHHHHCCCCCCC | 30.75 | 21440633 | |
| 727 | Phosphorylation | SKNKKIKSTLLRDDV CCCCCCCHHHCCCCC | 27.97 | 22369663 | |
| 728 | Phosphorylation | KNKKIKSTLLRDDVD CCCCCCHHHCCCCCC | 25.47 | 22369663 | |
| 737 | Phosphorylation | LRDDVDNSPLGSNTP CCCCCCCCCCCCCCC | 19.62 | 22369663 | |
| 741 | Phosphorylation | VDNSPLGSNTPLPSS CCCCCCCCCCCCCCC | 45.25 | 23749301 | |
| 743 | Phosphorylation | NSPLGSNTPLPSSES CCCCCCCCCCCCCHH | 28.09 | 29136822 | |
| 747 | Phosphorylation | GSNTPLPSSESKISG CCCCCCCCCHHHCCC | 55.19 | 29136822 | |
| 748 | Phosphorylation | SNTPLPSSESKISGL CCCCCCCCHHHCCCC | 43.90 | 29136822 | |
| 753 | Phosphorylation | PSSESKISGLKLQQK CCCHHHCCCCCHHHC | 41.64 | 21551504 | |
| 794 | Phosphorylation | SNEIMSGSPSSYLGS CCCCCCCCCCHHCCC | 17.82 | 19779198 | |
| 796 | Phosphorylation | EIMSGSPSSYLGSSH CCCCCCCCHHCCCCC | 33.06 | 19779198 | |
| 798 | Phosphorylation | MSGSPSSYLGSSHTR CCCCCCHHCCCCCCC | 21.30 | 21440633 | |
| 802 | Phosphorylation | PSSYLGSSHTRTSSK CCHHCCCCCCCCCHH | 27.38 | 19779198 | |
| 804 | Phosphorylation | SYLGSSHTRTSSKLS HHCCCCCCCCCHHHC | 37.27 | 19779198 | |
| 806 | Phosphorylation | LGSSHTRTSSKLSNM CCCCCCCCCHHHCCC | 38.21 | 28889911 | |
| 808 | Phosphorylation | SSHTRTSSKLSNMSD CCCCCCCHHHCCCCC | 36.68 | 23749301 | |
| 811 | Phosphorylation | TRTSSKLSNMSDKAA CCCCHHHCCCCCCEE | 33.93 | 28889911 | |
| 814 | Phosphorylation | SSKLSNMSDKAAFIT CHHHCCCCCCEEEEE | 39.96 | 23749301 | |
| 826 | Phosphorylation | FITEGQKSKHDDSNT EEECCCCCCCCCCCC | 27.60 | 20377248 | |
| 831 | Phosphorylation | QKSKHDDSNTYSLTQ CCCCCCCCCCCCHHH | 36.81 | 19823750 | |
| 833 | Phosphorylation | SKHDDSNTYSLTQQL CCCCCCCCCCHHHHH | 20.59 | 24961812 | |
| 834 | Phosphorylation | KHDDSNTYSLTQQLK CCCCCCCCCHHHHHH | 13.11 | 24961812 | |
| 835 | Phosphorylation | HDDSNTYSLTQQLKH CCCCCCCCHHHHHHH | 23.93 | 28889911 | |
| 837 | Phosphorylation | DSNTYSLTQQLKHRI CCCCCCHHHHHHHHH | 14.34 | 19823750 | |
| 845 | Phosphorylation | QQLKHRISETWVDIK HHHHHHHHCCEEECC | 29.00 | 19823750 | |
| 847 | Phosphorylation | LKHRISETWVDIKSP HHHHHHCCEEECCCC | 24.81 | 24961812 | |
| 878 | Phosphorylation | WKDVWPKYVARKYSK HHHHHHHHHHHHHCC | 8.68 | 19823750 | |
| 883 | Phosphorylation | PKYVARKYSKWRSFT HHHHHHHHCCCCCCC | 15.21 | 19823750 | |
| 884 | Phosphorylation | KYVARKYSKWRSFTT HHHHHHHCCCCCCCC | 28.86 | 19823750 | |
| 888 | Phosphorylation | RKYSKWRSFTTPAEL HHHCCCCCCCCCCCC | 26.32 | 19823750 | |
| 890 | Phosphorylation | YSKWRSFTTPAELPI HCCCCCCCCCCCCCE | 32.87 | 19823750 | |
| 891 | Phosphorylation | SKWRSFTTPAELPIT CCCCCCCCCCCCCEE | 20.63 | 19823750 | |
| 898 | Phosphorylation | TPAELPITISDFPSK CCCCCCEEECCCCCC | 16.70 | 19823750 | |
| 900 | Phosphorylation | AELPITISDFPSKDD CCCCEEECCCCCCCC | 25.25 | 19823750 | |
| 904 | Phosphorylation | ITISDFPSKDDFDRN EEECCCCCCCCCCCC | 49.03 | 19823750 | |
| 918 | Phosphorylation | NFIFRNHSVTLNTDQ CCEECCCCEEECCCH | 21.98 | 30377154 | |
| 923 | Phosphorylation | NHSVTLNTDQEQYNQ CCCEEECCCHHHHHH | 42.02 | 30377154 | |
| 928 | Phosphorylation | LNTDQEQYNQTYKDL ECCCHHHHHHHHHHH | 14.42 | 28889911 | |
| 931 | Phosphorylation | DQEQYNQTYKDLLRD CHHHHHHHHHHHHHH | 28.97 | 28889911 | |
| 1285 | Phosphorylation | DTNKLEKTNSHRSTL CCCCCCCCCCCCCCC | 32.36 | 21551504 | |
| 1287 | Phosphorylation | NKLEKTNSHRSTLSD CCCCCCCCCCCCCCC | 26.05 | 21440633 | |
| 1290 | Phosphorylation | EKTNSHRSTLSDPKQ CCCCCCCCCCCCHHH | 28.42 | 21440633 | |
| 1291 | Phosphorylation | KTNSHRSTLSDPKQM CCCCCCCCCCCHHHH | 30.18 | 17287358 | |
| 1293 | Phosphorylation | NSHRSTLSDPKQMLR CCCCCCCCCHHHHHH | 52.54 | 25752575 | |
| 1303 | Phosphorylation | KQMLRKASTGSSNDP HHHHHHHHCCCCCCH | 36.01 | 20377248 | |
| 1304 | Phosphorylation | QMLRKASTGSSNDPS HHHHHHHCCCCCCHH | 46.04 | 25752575 | |
| 1306 | Phosphorylation | LRKASTGSSNDPSAM HHHHHCCCCCCHHHC | 26.51 | 20377248 | |
| 1307 | Phosphorylation | RKASTGSSNDPSAMT HHHHCCCCCCHHHCC | 46.74 | 21440633 | |
| 1311 | Phosphorylation | TGSSNDPSAMTPFSS CCCCCCHHHCCCHHH | 33.27 | 19779198 | |
| 1314 | Phosphorylation | SNDPSAMTPFSSVVP CCCHHHCCCHHHHHH | 22.39 | 19779198 | |
| 1317 | Phosphorylation | PSAMTPFSSVVPAIS HHHCCCHHHHHHCCC | 24.35 | 19779198 | |
| 1318 | Phosphorylation | SAMTPFSSVVPAISA HHCCCHHHHHHCCCC | 27.75 | 19779198 | |
| 1324 | Phosphorylation | SSVVPAISASNASVA HHHHHCCCCCCCCCC | 27.96 | 19779198 | |
| 1326 | Phosphorylation | VVPAISASNASVADA HHHCCCCCCCCCCCC | 26.58 | 19779198 | |
| 1329 | Phosphorylation | AISASNASVADAKEP CCCCCCCCCCCCCCC | 23.30 | 21551504 | |
| 1544 | Phosphorylation | KIHSASSSSLDAQKV EEEECCCCCCCHHHH | 32.21 | 21551504 | |
| 1545 | Phosphorylation | IHSASSSSLDAQKVI EEECCCCCCCHHHHH | 32.01 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IML1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IML1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IML1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680; SER-737; SER-835AND SER-1293, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1291, AND MASSSPECTROMETRY. | |
