LAM5_YEAST - dbPTM
LAM5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAM5_YEAST
UniProt AC P43560
Protein Name Membrane-anchored lipid-binding protein LAM5 {ECO:0000303|PubMed:26001273}
Gene Name LAM5 {ECO:0000303|PubMed:26001273}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 674
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein . Localizes to intracellular puncta representing endoplasmic reticulum (ER)-mitochondrion membrane contact sites, nucleus-vacuole junctions (NVJ) and other non-NVJ ER-vacuole contact sites
Protein Description May be involved in sterol transfer between intracellular membranes..
Protein Sequence MSDVDNWEPVSDNEDSTDSVKQLGPPFEHASNNDNAGDTEAESLQEVPLNTETNDVRKNLVVITNQSAADEHPTEIKHDQSRTSSTSSFFSGMISSFKSNVPSPVSRSTTPTSPVSQPSIISHRREPSMGSKRRSSRRISNATIAEIGSPLQQVEKPDEVKTRLTPSQMKEDNYDHRRFVEERYMDTPYHYASEQRNKDFHETFKSVPKDDRLLDDFNCGLNRELLYQGKLYITETHLCFNSNVLGWIAKVLIAFEDVTFMEKTSAAGLFPSAISIETKMGKTLFNGFISRDAAFGLMKEVWSRTLLQKDMASENINTKAEKSGNGKEIDDAINSIDEENNDKDANDNDTNENDDENISTNETTPNSTSSSPDKEKEKAYKLRADSSYQYDGPIYHHSTSFPAEPMANNEFVLKELPFDCAPGILFEIMFNSEQNEFLLDFLRGQEGSQITTIPNFTSIDGSSMTLKREYSYEKALHFPAGPKSTTCYVAEVIKRKDPDTYYEVISSIRTPNVPSGGSFSTKTRYLIRWNDEITCLLRVSFWVEWTGSSWIKGMVENGCKNGQLEAAQLMERILSKFIKNNVEECQITISKEEEEQDDKEVKNKLKEVDLEQPREAVVTAPAIAEQQGLKVTMETWLFLYLIVVVLLLFNLFYIRSIAVSLHQLVKLQLVELKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDVDNWEP
------CCCCCCCCC		28152593
11PhosphorylationVDNWEPVSDNEDSTD
CCCCCCCCCCCCCCH		28152593
16PhosphorylationPVSDNEDSTDSVKQL
CCCCCCCCCHHHHHH		24961812
17PhosphorylationVSDNEDSTDSVKQLG
CCCCCCCCHHHHHHC		24961812
19PhosphorylationDNEDSTDSVKQLGPP
CCCCCCHHHHHHCCC		24961812
31PhosphorylationGPPFEHASNNDNAGD
CCCCCCCCCCCCCCC		19823750
39PhosphorylationNNDNAGDTEAESLQE
CCCCCCCCCCHHHHC		21440633
43PhosphorylationAGDTEAESLQEVPLN
CCCCCCHHHHCCCCC		20377248
51PhosphorylationLQEVPLNTETNDVRK
HHCCCCCCCCCCCHH		19823750
53PhosphorylationEVPLNTETNDVRKNL
CCCCCCCCCCCHHCE		19823750
74PhosphorylationSAADEHPTEIKHDQS
CCCCCCCCCCCCCCC		25704821
84PhosphorylationKHDQSRTSSTSSFFS
CCCCCCCCCCHHHHH		27017623
85PhosphorylationHDQSRTSSTSSFFSG
CCCCCCCCCHHHHHH		27017623
88PhosphorylationSRTSSTSSFFSGMIS
CCCCCCHHHHHHHHH		27017623
99PhosphorylationGMISSFKSNVPSPVS
HHHHHHHHCCCCCCC		22369663
103PhosphorylationSFKSNVPSPVSRSTT
HHHHCCCCCCCCCCC		22369663
106PhosphorylationSNVPSPVSRSTTPTS
HCCCCCCCCCCCCCC		22369663
108PhosphorylationVPSPVSRSTTPTSPV
CCCCCCCCCCCCCCC		22369663
109PhosphorylationPSPVSRSTTPTSPVS
CCCCCCCCCCCCCCC		22369663
110PhosphorylationSPVSRSTTPTSPVSQ
CCCCCCCCCCCCCCC		22369663
112PhosphorylationVSRSTTPTSPVSQPS
CCCCCCCCCCCCCCC		22369663
113PhosphorylationSRSTTPTSPVSQPSI
CCCCCCCCCCCCCCC		22369663
116PhosphorylationTTPTSPVSQPSIISH
CCCCCCCCCCCCCCC		22890988
119PhosphorylationTSPVSQPSIISHRRE
CCCCCCCCCCCCCCC		22890988
122PhosphorylationVSQPSIISHRREPSM
CCCCCCCCCCCCCCC		22890988
128PhosphorylationISHRREPSMGSKRRS
CCCCCCCCCCCCCCC		21551504
131PhosphorylationRREPSMGSKRRSSRR
CCCCCCCCCCCCCHH		21440633
135PhosphorylationSMGSKRRSSRRISNA
CCCCCCCCCHHCCCC		24961812
136PhosphorylationMGSKRRSSRRISNAT
CCCCCCCCHHCCCCC		24961812
140PhosphorylationRRSSRRISNATIAEI
CCCCHHCCCCCHHHC		17330950
143PhosphorylationSRRISNATIAEIGSP
CHHCCCCCHHHCCCC		17330950
149PhosphorylationATIAEIGSPLQQVEK
CCHHHCCCCCHHCCC		17330950
165PhosphorylationDEVKTRLTPSQMKED
CCCCCCCCHHHHHCC		20377248
323PhosphorylationINTKAEKSGNGKEID
CCCHHHHCCCCCHHH		28889911
335PhosphorylationEIDDAINSIDEENND
HHHHHHHHCCCCCCC		22369663
359PhosphorylationENDDENISTNETTPN
CCCCCCCCCCCCCCC		20377248
448PhosphorylationFLRGQEGSQITTIPN
HHCCCCCCCEEECCC		27017623
451PhosphorylationGQEGSQITTIPNFTS
CCCCCCEEECCCCCE		27017623
462PhosphorylationNFTSIDGSSMTLKRE
CCCEECCCCCEEEEE		27017623
506PhosphorylationDTYYEVISSIRTPNV
CCHHHHHHHCCCCCC		27017623
520PhosphorylationVPSGGSFSTKTRYLI
CCCCCCCCCCEEEEE		27017623
521PhosphorylationPSGGSFSTKTRYLIR
CCCCCCCCCEEEEEE		27017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAM5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAM5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAM5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
COPG_YEASTSEC21physical
22940862
COPD_YEASTRET2physical
22940862
COPA_YEASTCOP1physical
22940862
NCBP2_YEASTCBC2genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
PYC2_YEASTPYC2genetic
27708008
SWC5_YEASTSWC5genetic
27708008
RIM1_YEASTRIM1genetic
27708008
LCMT1_YEASTPPM1genetic
27708008
MED5_YEASTNUT1genetic
27708008
ATC1_YEASTPMR1genetic
27708008
IRE1_YEASTIRE1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
PGM1_YEASTPGM1genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
ARP6_YEASTARP6genetic
27708008
COQ11_YEASTYLR290Cgenetic
27708008
ARMT1_YEASTYMR027Wgenetic
27708008
CHMU_YEASTARO7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAM5_YEAST

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Related Literatures of Post-Translational Modification

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