ARMT1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARMT1_YEAST
• UniProt AC: Q04371
• Protein Name: Protein-glutamate O-methyltransferase {ECO:0000250|UniProtKB:Q9H993}
• Gene Name: YMR027W
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 470
• Protein Description: O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues..
• Protein Sequence: MTIPGRFMTIDKGTFGEYTASTRWPIIIQNAIDDLSKHQETEKSNGTKFEQGEVIKKELKEFRQEIIDRVPLRPFTEEEIKIANVPLSFNEYLKKHPEVNWGAVEWLFSEVYLYRRVNVLFQRQCEWAKFDIFNRLKQSTFESSFYGVVELALRYENLLPQLREMKQNPGNEIDDILKVLFKEFIEISLWGNATDLSLLTNATLEDIKSIQGAKARAASESKIVVNDTEKAWEVLTKARADANSREIRVDFVLDNSGFELYADLMLAAFLLQSGLATKCIFHAKDIPYMVSDVMLKDFDILVHDLRDREFFPSGEPSTKESRALDLFAGEMEKFVSSGKIEFREDSFWTTELDYWNLDANETKYHGSILHKDLQKSNLVIFKGDLNYRKLTGDRKWPRTTKWETAIGPLATNGITSLSLRTCKADVQVALPEGLDAKLSQEWEKENPGRGSWWCCSGKWAVICFCSGIHK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	TIPGRFMTIDKGTFG CCCCCEEEECCCCCC		28889911
14	Phosphorylation	FMTIDKGTFGEYTAS EEEECCCCCCCCCCC		27017623
36	Phosphorylation	QNAIDDLSKHQETEK EHHHHHHHHCHHHHH		27017623
48	Acetylation	TEKSNGTKFEQGEVI HHHHCCCCCHHHHHH		22865919
94	Acetylation	LSFNEYLKKHPEVNW CCHHHHHHHCCCCCH		24489116
139	Phosphorylation	IFNRLKQSTFESSFY HHHHHHHHHHHHHHH		19823750
140	Phosphorylation	FNRLKQSTFESSFYG HHHHHHHHHHHHHHH		19823750
143	Phosphorylation	LKQSTFESSFYGVVE HHHHHHHHHHHHHHH		19823750
144	Phosphorylation	KQSTFESSFYGVVEL HHHHHHHHHHHHHHH		19823750
146	Phosphorylation	STFESSFYGVVELAL HHHHHHHHHHHHHHH		19823750
155	Phosphorylation	VVELALRYENLLPQL HHHHHHHHHCHHHHH		19823750
214	2-Hydroxyisobutyrylation	IKSIQGAKARAASES HHHHHCHHHHHHHCC		-
219	Phosphorylation	GAKARAASESKIVVN CHHHHHHHCCCEEEC		23749301
230	Acetylation	IVVNDTEKAWEVLTK EEECCHHHHHHHHHH		24489116
288	Phosphorylation	FHAKDIPYMVSDVML HHHHCCCHHHEHHHH		22369663
291	Phosphorylation	KDIPYMVSDVMLKDF HCCCHHHEHHHHHCC		22369663
333	Acetylation	LFAGEMEKFVSSGKI HHHHHHHHHHHCCCE		24489116
339	Acetylation	EKFVSSGKIEFREDS HHHHHCCCEEECCCC		24489116
371	Acetylation	YHGSILHKDLQKSNL ECCCCCCHHHHHCCE		22865919
423	Ubiquitination	SLSLRTCKADVQVAL EEEHHCCCCCEEEEC		23749301
451	Phosphorylation	KENPGRGSWWCCSGK HHCCCCCCEEECCCC		21440633

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARMT1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARMT1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARMT1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VATG_YEAST	VMA10	physical	16554755
VATH_YEAST	VMA13	physical	16554755
HSP72_YEAST	SSA2	physical	19536198
SSB1_YEAST	SSB1	physical	19536198

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.