| UniProt ID | HSP72_YEAST | |
|---|---|---|
| UniProt AC | P10592 | |
| Protein Name | Heat shock protein SSA2 | |
| Gene Name | SSA2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 639 | |
| Subcellular Localization | Cytoplasm. Secreted, cell wall. | |
| Protein Description | May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. A functional difference between SSA1 and SSA2 proteins is expected. SSA2 can participate in the ATP-dependent disassembly of clathrin-coated vesicles.. | |
| Protein Sequence | MSKAVGIDLGTTYSCVAHFSNDRVDIIANDQGNRTTPSFVGFTDTERLIGDAAKNQAAMNPANTVFDAKRLIGRNFNDPEVQGDMKHFPFKLIDVDGKPQIQVEFKGETKNFTPEQISSMVLGKMKETAESYLGAKVNDAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKGKEEHVLIFDLGGGTFDVSLLSIEDGIFEVKATAGDTHLGGEDFDNRLVNHFIQEFKRKNKKDLSTNQRALRRLRTACERAKRTLSSSAQTSVEIDSLFEGIDFYTSITRARFEELCADLFRSTLDPVEKVLRDAKLDKSQVDEIVLVGGSTRIPKVQKLVTDYFNGKEPNRSINPDEAVAYGAAVQAAILTGDESSKTQDLLLLDVAPLSLGIETAGGVMTKLIPRNSTIPTKKSEVFSTYADNQPGVLIQVFEGERAKTKDNNLLGKFELSGIPPAPRGVPQIEVTFDVDSNGILNVSAVEKGTGKSNKITITNDKGRLSKEDIEKMVAEAEKFKEEDEKESQRIASKNQLESIAYSLKNTISEAGDKLEQADKDAVTKKAEETIAWLDSNTTATKEEFDDQLKELQEVANPIMSKLYQAGGAPEGAAPGGFPGGAPPAPEAEGPTVEEVD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSKAVGIDL ------CCCCCCEEC | 29.35 | 9298649 | |
| 3 | Ubiquitination | -----MSKAVGIDLG -----CCCCCCEECC | 45.88 | 17644757 | |
| 12 | Phosphorylation | VGIDLGTTYSCVAHF CCEECCCCEEEEEEC | 16.19 | 28889911 | |
| 14 | Phosphorylation | IDLGTTYSCVAHFSN EECCCCEEEEEECCC | 10.46 | 28889911 | |
| 20 | Phosphorylation | YSCVAHFSNDRVDII EEEEEECCCCCEEEE | 28.14 | 17287358 | |
| 35 | Phosphorylation | ANDQGNRTTPSFVGF ECCCCCCCCCCCCCC | 47.24 | 27214570 | |
| 36 | Phosphorylation | NDQGNRTTPSFVGFT CCCCCCCCCCCCCCC | 17.44 | 25752575 | |
| 38 | Phosphorylation | QGNRTTPSFVGFTDT CCCCCCCCCCCCCCH | 30.39 | 28889911 | |
| 45 | Phosphorylation | SFVGFTDTERLIGDA CCCCCCCHHHHHHHH | 21.68 | 11283598 | |
| 54 | Acetylation | RLIGDAAKNQAAMNP HHHHHHHHHCHHCCH | 51.84 | - | |
| 54 | Ubiquitination | RLIGDAAKNQAAMNP HHHHHHHHHCHHCCH | 51.84 | 23749301 | |
| 69 | Acetylation | ANTVFDAKRLIGRNF HHHHHHHHHHHCCCC | 49.97 | 24489116 | |
| 69 | Succinylation | ANTVFDAKRLIGRNF HHHHHHHHHHHCCCC | 49.97 | 23954790 | |
| 69 | Ubiquitination | ANTVFDAKRLIGRNF HHHHHHHHHHHCCCC | 49.97 | 17644757 | |
| 86 | Acetylation | PEVQGDMKHFPFKLI HHHCCCCCCCCEEEE | 47.00 | 24489116 | |
| 86 | Succinylation | PEVQGDMKHFPFKLI HHHCCCCCCCCEEEE | 47.00 | 23954790 | |
| 86 | Ubiquitination | PEVQGDMKHFPFKLI HHHCCCCCCCCEEEE | 47.00 | 23749301 | |
| 91 | Ubiquitination | DMKHFPFKLIDVDGK CCCCCCEEEECCCCC | 44.78 | 22817900 | |
| 98 | Ubiquitination | KLIDVDGKPQIQVEF EEECCCCCEEEEEEE | 29.32 | 23749301 | |
| 106 | Ubiquitination | PQIQVEFKGETKNFT EEEEEEECCCCCCCC | 42.19 | 22817900 | |
| 109 | Phosphorylation | QVEFKGETKNFTPEQ EEEECCCCCCCCHHH | 39.70 | 21440633 | |
| 110 | Ubiquitination | VEFKGETKNFTPEQI EEECCCCCCCCHHHH | 45.84 | 23749301 | |
| 113 | Phosphorylation | KGETKNFTPEQISSM CCCCCCCCHHHHHHH | 35.00 | 21440633 | |
| 119 | Phosphorylation | FTPEQISSMVLGKMK CCHHHHHHHHHHHHH | 17.97 | 21440633 | |
| 124 | Ubiquitination | ISSMVLGKMKETAES HHHHHHHHHHHHHHH | 42.51 | 22817900 | |
| 126 | Ubiquitination | SMVLGKMKETAESYL HHHHHHHHHHHHHHH | 56.23 | 23749301 | |
| 128 | Phosphorylation | VLGKMKETAESYLGA HHHHHHHHHHHHHCC | 30.15 | 21440633 | |
| 131 | Phosphorylation | KMKETAESYLGAKVN HHHHHHHHHHCCCCC | 24.16 | 21440633 | |
| 132 | Phosphorylation | MKETAESYLGAKVND HHHHHHHHHCCCCCC | 10.72 | 21440633 | |
| 136 | Ubiquitination | AESYLGAKVNDAVVT HHHHHCCCCCCEEEE | 39.51 | 23749301 | |
| 143 | Phosphorylation | KVNDAVVTVPAYFND CCCCEEEEEEECCCH | 17.74 | 28132839 | |
| 147 | Phosphorylation | AVVTVPAYFNDSQRQ EEEEEEECCCHHHCC | 9.24 | 29734811 | |
| 151 | Phosphorylation | VPAYFNDSQRQATKD EEECCCHHHCCHHCC | 28.50 | 22369663 | |
| 156 | Phosphorylation | NDSQRQATKDAGTIA CHHHCCHHCCCCCCC | 22.56 | 21440633 | |
| 157 | Ubiquitination | DSQRQATKDAGTIAG HHHCCHHCCCCCCCC | 48.90 | 23749301 | |
| 161 | Phosphorylation | QATKDAGTIAGLNVL CHHCCCCCCCCCHHH | 14.90 | 30377154 | |
| 175 | Phosphorylation | LRIINEPTAAAIAYG HHHCCCHHHHHHHHC | 23.81 | 21440633 | |
| 185 | Ubiquitination | AIAYGLDKKGKEEHV HHHHCCCCCCCEEEE | 69.35 | 22817900 | |
| 186 | Ubiquitination | IAYGLDKKGKEEHVL HHHCCCCCCCEEEEE | 74.92 | 22817900 | |
| 188 | Ubiquitination | YGLDKKGKEEHVLIF HCCCCCCCEEEEEEE | 69.66 | 22817900 | |
| 217 | Ubiquitination | EDGIFEVKATAGDTH CCCEEEEEEEECCCC | 32.59 | 17644757 | |
| 219 | Phosphorylation | GIFEVKATAGDTHLG CEEEEEEEECCCCCC | 26.00 | 21440633 | |
| 223 | Phosphorylation | VKATAGDTHLGGEDF EEEEECCCCCCCCCH | 20.34 | 22369663 | |
| 243 | Ubiquitination | NHFIQEFKRKNKKDL HHHHHHHHHHCHHCC | 62.81 | 23749301 | |
| 245 | Ubiquitination | FIQEFKRKNKKDLST HHHHHHHHCHHCCCH | 73.95 | 22817900 | |
| 247 | Ubiquitination | QEFKRKNKKDLSTNQ HHHHHHCHHCCCHHH | 51.18 | 22817900 | |
| 248 | Ubiquitination | EFKRKNKKDLSTNQR HHHHHCHHCCCHHHH | 73.60 | 22817900 | |
| 252 | Phosphorylation | KNKKDLSTNQRALRR HCHHCCCHHHHHHHH | 42.54 | 19779198 | |
| 268 | Ubiquitination | RTACERAKRTLSSSA HHHHHHHHHHHCCCC | 52.73 | 17644757 | |
| 316 | Ubiquitination | STLDPVEKVLRDAKL HCCCHHHHHHHHCCC | 46.97 | 23749301 | |
| 325 | Ubiquitination | LRDAKLDKSQVDEIV HHHCCCCHHHCCEEE | 53.90 | 24961812 | |
| 326 | Phosphorylation | RDAKLDKSQVDEIVL HHCCCCHHHCCEEEE | 34.79 | 25521595 | |
| 337 | Phosphorylation | EIVLVGGSTRIPKVQ EEEEECCCCCCHHHH | 14.48 | 25521595 | |
| 338 | Phosphorylation | IVLVGGSTRIPKVQK EEEECCCCCCHHHHH | 35.57 | 21440633 | |
| 342 | Ubiquitination | GGSTRIPKVQKLVTD CCCCCCHHHHHHHHH | 55.73 | 22817900 | |
| 345 | Ubiquitination | TRIPKVQKLVTDYFN CCCHHHHHHHHHHHC | 48.16 | 24961812 | |
| 348 | Phosphorylation | PKVQKLVTDYFNGKE HHHHHHHHHHHCCCC | 35.10 | 21440633 | |
| 350 | Phosphorylation | VQKLVTDYFNGKEPN HHHHHHHHHCCCCCC | 6.92 | 21440633 | |
| 354 | Ubiquitination | VTDYFNGKEPNRSIN HHHHHCCCCCCCCCC | 71.72 | 23749301 | |
| 359 | Phosphorylation | NGKEPNRSINPDEAV CCCCCCCCCCHHHHH | 33.10 | 22369663 | |
| 368 | Phosphorylation | NPDEAVAYGAAVQAA CHHHHHHHHHHHHHH | 10.74 | 22369663 | |
| 378 | Phosphorylation | AVQAAILTGDESSKT HHHHHHHHCCCCCCC | 36.15 | 22369663 | |
| 382 | Phosphorylation | AILTGDESSKTQDLL HHHHCCCCCCCCCEE | 41.70 | 21551504 | |
| 383 | Phosphorylation | ILTGDESSKTQDLLL HHHCCCCCCCCCEEE | 37.36 | 22369663 | |
| 384 | Ubiquitination | LTGDESSKTQDLLLL HHCCCCCCCCCEEEE | 60.53 | 17644757 | |
| 409 | Ubiquitination | TAGGVMTKLIPRNST ECCCHHEEEECCCCC | 26.73 | 17644757 | |
| 415 | Phosphorylation | TKLIPRNSTIPTKKS EEEECCCCCCCCCHH | 29.06 | 22369663 | |
| 416 | Phosphorylation | KLIPRNSTIPTKKSE EEECCCCCCCCCHHH | 34.23 | 22369663 | |
| 419 | Phosphorylation | PRNSTIPTKKSEVFS CCCCCCCCCHHHHHE | 47.45 | 21440633 | |
| 420 | Acetylation | RNSTIPTKKSEVFST CCCCCCCCHHHHHEE | 49.28 | 25381059 | |
| 420 | Ubiquitination | RNSTIPTKKSEVFST CCCCCCCCHHHHHEE | 49.28 | 23749301 | |
| 421 | Ubiquitination | NSTIPTKKSEVFSTY CCCCCCCHHHHHEEE | 55.09 | 23749301 | |
| 422 | Phosphorylation | STIPTKKSEVFSTYA CCCCCCHHHHHEEEC | 40.32 | 25521595 | |
| 426 | Phosphorylation | TKKSEVFSTYADNQP CCHHHHHEEECCCCC | 26.19 | 22369663 | |
| 427 | Phosphorylation | KKSEVFSTYADNQPG CHHHHHEEECCCCCC | 15.97 | 22369663 | |
| 428 | Phosphorylation | KSEVFSTYADNQPGV HHHHHEEECCCCCCE | 15.68 | 25521595 | |
| 446 | Ubiquitination | VFEGERAKTKDNNLL EEECCCCCCCCCCCC | 63.43 | 22817900 | |
| 448 | Ubiquitination | EGERAKTKDNNLLGK ECCCCCCCCCCCCCE | 58.72 | 23749301 | |
| 455 | Ubiquitination | KDNNLLGKFELSGIP CCCCCCCEEEECCCC | 35.32 | 23749301 | |
| 459 | Phosphorylation | LLGKFELSGIPPAPR CCCEEEECCCCCCCC | 27.72 | 22369663 | |
| 486 | Phosphorylation | SNGILNVSAVEKGTG CCCEEEEEEEECCCC | 26.06 | 23607784 | |
| 490 | Ubiquitination | LNVSAVEKGTGKSNK EEEEEEECCCCCCCC | 55.99 | 17644757 | |
| 492 | Phosphorylation | VSAVEKGTGKSNKIT EEEEECCCCCCCCEE | 53.13 | 22369663 | |
| 494 | Ubiquitination | AVEKGTGKSNKITIT EEECCCCCCCCEEEE | 51.17 | 22817900 | |
| 495 | Phosphorylation | VEKGTGKSNKITITN EECCCCCCCCEEEEC | 44.71 | 22369663 | |
| 497 | Ubiquitination | KGTGKSNKITITNDK CCCCCCCCEEEECCC | 48.60 | 23749301 | |
| 499 | Phosphorylation | TGKSNKITITNDKGR CCCCCCEEEECCCCC | 24.29 | 22369663 | |
| 501 | Phosphorylation | KSNKITITNDKGRLS CCCCEEEECCCCCCC | 28.81 | 22369663 | |
| 504 | Ubiquitination | KITITNDKGRLSKED CEEEECCCCCCCHHH | 48.26 | 23749301 | |
| 508 | Phosphorylation | TNDKGRLSKEDIEKM ECCCCCCCHHHHHHH | 32.41 | 30377154 | |
| 509 | Ubiquitination | NDKGRLSKEDIEKMV CCCCCCCHHHHHHHH | 65.09 | 23749301 | |
| 514 | Ubiquitination | LSKEDIEKMVAEAEK CCHHHHHHHHHHHHH | 38.72 | 24961812 | |
| 521 | Ubiquitination | KMVAEAEKFKEEDEK HHHHHHHHHHHHHHH | 69.64 | 23749301 | |
| 523 | Ubiquitination | VAEAEKFKEEDEKES HHHHHHHHHHHHHHH | 71.86 | 23793018 | |
| 528 | Ubiquitination | KFKEEDEKESQRIAS HHHHHHHHHHHHHHH | 75.00 | 24961812 | |
| 530 | Phosphorylation | KEEDEKESQRIASKN HHHHHHHHHHHHHHH | 35.51 | 28889911 | |
| 535 | Phosphorylation | KESQRIASKNQLESI HHHHHHHHHHHHHHH | 29.75 | 23749301 | |
| 536 | Ubiquitination | ESQRIASKNQLESIA HHHHHHHHHHHHHHH | 39.43 | 23749301 | |
| 541 | Phosphorylation | ASKNQLESIAYSLKN HHHHHHHHHHHHHHH | 22.55 | 22369663 | |
| 545 | Phosphorylation | QLESIAYSLKNTISE HHHHHHHHHHHHHHH | 24.68 | 22369663 | |
| 547 | Ubiquitination | ESIAYSLKNTISEAG HHHHHHHHHHHHHHH | 46.21 | 24961812 | |
| 549 | Phosphorylation | IAYSLKNTISEAGDK HHHHHHHHHHHHHHH | 25.05 | 20377248 | |
| 551 | Phosphorylation | YSLKNTISEAGDKLE HHHHHHHHHHHHHHH | 21.25 | 22369663 | |
| 556 | Ubiquitination | TISEAGDKLEQADKD HHHHHHHHHHHHCHH | 53.67 | 23749301 | |
| 562 | Acetylation | DKLEQADKDAVTKKA HHHHHHCHHHHHHHH | 51.07 | 24489116 | |
| 562 | Ubiquitination | DKLEQADKDAVTKKA HHHHHHCHHHHHHHH | 51.07 | 17644757 | |
| 566 | Phosphorylation | QADKDAVTKKAEETI HHCHHHHHHHHHHHH | 28.66 | 21440633 | |
| 567 | Ubiquitination | ADKDAVTKKAEETIA HCHHHHHHHHHHHHH | 43.30 | 17644757 | |
| 568 | Ubiquitination | DKDAVTKKAEETIAW CHHHHHHHHHHHHHH | 52.22 | 17644757 | |
| 584 | Acetylation | DSNTTATKEEFDDQL CCCCCCCHHHHHHHH | 53.43 | 24489116 | |
| 584 | Ubiquitination | DSNTTATKEEFDDQL CCCCCCCHHHHHHHH | 53.43 | 24961812 | |
| 592 | Acetylation | EEFDDQLKELQEVAN HHHHHHHHHHHHHHH | 51.23 | 24489116 | |
| 592 | Ubiquitination | EEFDDQLKELQEVAN HHHHHHHHHHHHHHH | 51.23 | 17644757 | |
| 603 | Phosphorylation | EVANPIMSKLYQAGG HHHHHHHHHHHHCCC | 21.89 | 28152593 | |
| 604 | Ubiquitination | VANPIMSKLYQAGGA HHHHHHHHHHHCCCC | 33.56 | 17644757 | |
| 634 | Phosphorylation | APEAEGPTVEEVD-- CCCCCCCCCCCCC-- | 51.94 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HSP72_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HSP72_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HSP72_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Proteome studies of Saccharomyces cerevisiae: identification andcharacterization of abundant proteins."; Garrels J.I., McLaughlin C.S., Warner J.R., Futcher B., Latter G.I.,Kobayashi R., Schwender B., Volpe T., Anderson D.S.,Mesquita-Fuentes R., Payne W.E.; Electrophoresis 18:1347-1360(1997). Cited for: ACETYLATION AT SER-2, AND PHOSPHORYLATION. | |
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; THR-35; THR-36 ANDSER-551, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-551, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-426, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-551, AND MASSSPECTROMETRY. | |
| Ubiquitylation | |
| Reference | PubMed |
| "A proteomics approach to understanding protein ubiquitination."; Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.; Nat. Biotechnol. 21:921-926(2003). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-556, AND MASSSPECTROMETRY. | |
