PNPH_YEAST - dbPTM
PNPH_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PNPH_YEAST
UniProt AC Q05788
Protein Name Purine nucleoside phosphorylase
Gene Name PNP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 311
Subcellular Localization
Protein Description The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine (By similarity)..
Protein Sequence MSDILNVSQQREAITKAAAYISAILEPHFKNTTNFEPPRTLIICGSGLGGISTKLSRDNPPPVTVPYQDIPGFKKSTVPGHSGTLMFGSMNGSPVVLMNGRLHGYEGNTLFETTFPIRVLNHMGHVRNLIVTNAAGGINAKYQACDLMCIYDHLNIPGLAGQHPLRGPNLDEDGPRFLALSDAYDLELRKLLFKKWKELKIQRPLHEGTYTFVSGPTFETRAESKMIRMLGGDAVGMSTVPEVIVARHCGWRVLALSLITNTCVVDSPASALDESPVPLEKGKATHAEVLENGKIASNDVQNLIAAVMGEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSDILNVSQ
------CCCCCCHHH		33.1022814378
64PhosphorylationRDNPPPVTVPYQDIP
CCCCCCCCCCHHCCC		22.8727017623
76PhosphorylationDIPGFKKSTVPGHSG
CCCCCCCCCCCCCCC		34.9227017623
77PhosphorylationIPGFKKSTVPGHSGT
CCCCCCCCCCCCCCE		39.3327017623
82PhosphorylationKSTVPGHSGTLMFGS
CCCCCCCCCEEEEEE		39.1127017623
132PhosphorylationHVRNLIVTNAAGGIN
CCCEEEEECCCCCCC		16.4927017623
267PhosphorylationTNTCVVDSPASALDE
HCCCCCCCCCHHCCC		15.6830377154
275PhosphorylationPASALDESPVPLEKG
CCHHCCCCCCCHHCC		30.7527214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PNPH_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PNPH_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PNPH_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSP72_YEASTSSA2physical
19536198
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
19536198
CDC24_YEASTCDC24genetic
27708008
ALG14_YEASTALG14genetic
27708008
RFC5_YEASTRFC5genetic
27708008
CALM_YEASTCMD1genetic
27708008
MAK5_YEASTMAK5genetic
27708008
APC11_YEASTAPC11genetic
27708008
UBC3_YEASTCDC34genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
MSS4_YEASTMSS4genetic
27708008
RMRP_YEASTSNM1genetic
27708008
GDI1_YEASTGDI1genetic
27708008
COG3_YEASTCOG3genetic
27708008
GNA1_YEASTGNA1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
GPI10_YEASTGPI10genetic
27708008
ZPR1_YEASTZPR1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
MOB1_YEASTMOB1genetic
27708008
DSN1_YEASTDSN1genetic
27708008
ARP4_YEASTARP4genetic
27708008
TIM16_YEASTPAM16genetic
27708008
KRE9_YEASTKRE9genetic
27708008
ARP3_YEASTARP3genetic
27708008
CDC11_YEASTCDC11genetic
27708008
CDC45_YEASTCDC45genetic
27708008
POB3_YEASTPOB3genetic
27708008
TAF13_YEASTTAF13genetic
27708008
ARPC2_YEASTARC35genetic
27708008
DED1_YEASTDED1genetic
27708008
SEC63_YEASTSEC63genetic
27708008
RRS1_YEASTRRS1genetic
27708008
RPA1_YEASTRPA190genetic
27708008
PSA7_YEASTPRE10genetic
27708008
SEC62_YEASTSEC62genetic
27708008
SYH_YEASTHTS1genetic
27708008
TF2B_YEASTSUA7genetic
27708008
BUR1_YEASTSGV1genetic
27708008
PSB6_YEASTPRE7genetic
27708008
TSC3_YEASTTSC3genetic
27708008
EIF3A_YEASTRPG1genetic
27708008
ALG1_YEASTALG1genetic
27708008
MED8_YEASTMED8genetic
27708008
MCM7_YEASTMCM7genetic
27708008
ARPC1_YEASTARC40genetic
27708008
CDC10_YEASTCDC10genetic
27708008
PRS4_YEASTRPT2genetic
27708008
UBC9_YEASTUBC9genetic
27708008
LUC7_YEASTLUC7genetic
27708008
SNU23_YEASTSNU23genetic
27708008
NSE4_YEASTNSE4genetic
27708008
RPB1_YEASTRPO21genetic
27708008
FAL1_YEASTFAL1genetic
27708008
RPC10_YEASTRPC11genetic
27708008
DBF4_YEASTDBF4genetic
27708008
MAK21_YEASTMAK21genetic
27708008
SEC1_YEASTSEC1genetic
27708008
CDC1_YEASTCDC1genetic
27708008
PCF11_YEASTPCF11genetic
27708008
RIFK_YEASTFMN1genetic
27708008
SNU56_YEASTSNU56genetic
27708008
SMT3_YEASTSMT3genetic
27708008
CDC4_YEASTCDC4genetic
27708008
ACT_YEASTACT1genetic
27708008
CDC14_YEASTCDC14genetic
27708008
NBP35_YEASTNBP35genetic
27708008
SP105_YEASTSPC105genetic
27708008
RCC1_YEASTSRM1genetic
27708008
CDC20_YEASTCDC20genetic
27708008
TIP20_YEASTTIP20genetic
27708008
SMD1_YEASTSMD1genetic
27708008
PRP31_YEASTPRP31genetic
27708008
SYV_YEASTVAS1genetic
27708008
CBF3A_YEASTCBF2genetic
27708008
SYYC_YEASTTYS1genetic
27708008
SYMC_YEASTMES1genetic
27708008
BIG1_YEASTBIG1genetic
27708008
SMC3_YEASTSMC3genetic
27708008
HACD_YEASTPHS1genetic
27708008
KTHY_YEASTCDC8genetic
27708008
GAA1_YEASTGAA1genetic
27708008
BET5_YEASTBET5genetic
27708008
PDS5_YEASTPDS5genetic
27708008
SPC24_YEASTSPC24genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
FCP1_YEASTFCP1genetic
27708008
HRP1_YEASTHRP1genetic
27708008
CH10_YEASTHSP10genetic
27708008
KRE5_YEASTKRE5genetic
27708008
EIF3B_YEASTPRT1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
CET1_YEASTCET1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PNPH_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-275, AND MASSSPECTROMETRY.

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