SYMC_YEAST - dbPTM
SYMC_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYMC_YEAST
UniProt AC P00958
Protein Name Methionine--tRNA ligase, cytoplasmic
Gene Name MES1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 751
Subcellular Localization Cytoplasm . Largely excluded from the nucleus.
Protein Description Catalyzes the attachment of methionine to tRNA(Met) in a two-step reaction: methionine is first activated by ATP to form Met-AMP and then transferred to the acceptor end of tRNA(Met)..
Protein Sequence MSFLISFDKSKKHPAHLQLANNLKIALALEYASKNLKPEVDNDNAAMELRNTKEPFLLFDANAILRYVMDDFEGQTSDKYQFALASLQNLLYHKELPQQHVEVLTNKAIENYLVELKEPLTTTDLILFANVYALNSSLVHSKFPELPSKVHNAVALAKKHVPRDSSSFKNIGAVKIQADLTVKPKDSEILPKPNERNILITSALPYVNNVPHLGNIIGSVLSADIFARYCKGRNYNALFICGTDEYGTATETKALEEGVTPRQLCDKYHKIHSDVYKWFQIGFDYFGRTTTDKQTEIAQHIFTKLNSNGYLEEQSMKQLYCPVHNSYLADRYVEGECPKCHYDDARGDQCDKCGALLDPFELINPRCKLDDASPEPKYSDHIFLSLDKLESQISEWVEKASEEGNWSKNSKTITQSWLKDGLKPRCITRDLVWGTPVPLEKYKDKVLYVWFDATIGYVSITSNYTKEWKQWWNNPEHVSLYQFMGKDNVPFHTVVFPGSQLGTEENWTMLHHLNTTEYLQYENGKFSKSRGVGVFGNNAQDSGISPSVWRYYLASVRPESSDSHFSWDDFVARNNSELLANLGNFVNRLIKFVNAKYNGVVPKFDPKKVSNYDGLVKDINEILSNYVKEMELGHERRGLEIAMSLSARGNQFLQENKLDNTLFSQSPEKSDAVVAVGLNIIYAVSSIITPYMPEIGEKINKMLNAPALKIDDRFHLAILEGHNINKAEYLFQRIDEKKIDEWRAKYGGQQV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSFLISFDK
------CCEEEECCC		28.856371805
6Phosphorylation--MSFLISFDKSKKH
--CCEEEECCCCCCC		29.5530377154
9AcetylationSFLISFDKSKKHPAH
CEEEECCCCCCCHHH		63.2624489116
31PhosphorylationKIALALEYASKNLKP
HHHHHHHHHHHCCCC		19.6119823750
33PhosphorylationALALEYASKNLKPEV
HHHHHHHHHCCCCCC		22.6019795423
37SuccinylationEYASKNLKPEVDNDN
HHHHHCCCCCCCCCC		48.8323954790
37AcetylationEYASKNLKPEVDNDN
HHHHHCCCCCCCCCC		48.8324489116
53UbiquitinationAMELRNTKEPFLLFD
HHHHHHCCCCEEEEC		67.9217644757
53AcetylationAMELRNTKEPFLLFD
HHHHHHCCCCEEEEC		67.9224489116
67PhosphorylationDANAILRYVMDDFEG
CHHHHHHHHHHCCCC		9.1828889911
76PhosphorylationMDDFEGQTSDKYQFA
HHCCCCCCCCHHHHH		50.1528889911
80PhosphorylationEGQTSDKYQFALASL
CCCCCCHHHHHHHHH		17.5428889911
107UbiquitinationHVEVLTNKAIENYLV
HHHHHHHHHHHHHHH		45.5724961812
165PhosphorylationKKHVPRDSSSFKNIG
HHCCCCCCCCCCCCC		29.2119823750
166PhosphorylationKHVPRDSSSFKNIGA
HCCCCCCCCCCCCCE		44.0519823750
167PhosphorylationHVPRDSSSFKNIGAV
CCCCCCCCCCCCCEE		44.1619823750
169AcetylationPRDSSSFKNIGAVKI
CCCCCCCCCCCEEEE		49.9924489116
253UbiquitinationYGTATETKALEEGVT
CCCCHHHHHHHCCCC		44.7523749301
260PhosphorylationKALEEGVTPRQLCDK
HHHHCCCCHHHHHHH		24.5022369663
270AcetylationQLCDKYHKIHSDVYK
HHHHHHHHHCHHHHH		38.7422865919
293AcetylationFGRTTTDKQTEIAQH
CCCCCCCCHHHHHHH		57.9624489116
293UbiquitinationFGRTTTDKQTEIAQH
CCCCCCCCHHHHHHH		57.9623749301
304AcetylationIAQHIFTKLNSNGYL
HHHHHHHHHHCCCCC		34.6224489116
310PhosphorylationTKLNSNGYLEEQSMK
HHHHCCCCCCCHHHC		18.3929734811
326PhosphorylationLYCPVHNSYLADRYV
CCCCCCCHHHHHHHC		13.4730377154
368UbiquitinationELINPRCKLDDASPE
HHCCCCCCCCCCCCC		57.1223749301
373PhosphorylationRCKLDDASPEPKYSD
CCCCCCCCCCCCCCC		36.4722369663
377UbiquitinationDDASPEPKYSDHIFL
CCCCCCCCCCCCEEE		56.5817644757
378PhosphorylationDASPEPKYSDHIFLS
CCCCCCCCCCCEEEC		30.0025005228
388UbiquitinationHIFLSLDKLESQISE
CEEECHHHHHHHHHH		60.4917644757
394PhosphorylationDKLESQISEWVEKAS
HHHHHHHHHHHHHHH		20.1219779198
399UbiquitinationQISEWVEKASEEGNW
HHHHHHHHHHHHCCC		47.8217644757
407PhosphorylationASEEGNWSKNSKTIT
HHHHCCCCCCCCCCC		26.4219779198
411UbiquitinationGNWSKNSKTITQSWL
CCCCCCCCCCCHHHH		54.0323749301
419AcetylationTITQSWLKDGLKPRC
CCCHHHHHCCCCCCE		43.4224489116
441AcetylationGTPVPLEKYKDKVLY
CCCCCHHHHCCCEEE		66.3424489116
443AcetylationPVPLEKYKDKVLYVW
CCCHHHHCCCEEEEE		63.2424489116
529PhosphorylationENGKFSKSRGVGVFG
ECCCCCCCCCEEEEC		32.8222369663
576PhosphorylationDFVARNNSELLANLG
HHHHHCCHHHHHHHH		32.9224909858
591AcetylationNFVNRLIKFVNAKYN
HHHHHHHHHHHHHCC		48.1024489116
596AcetylationLIKFVNAKYNGVVPK
HHHHHHHHCCCCCCC		33.7624489116
596SuccinylationLIKFVNAKYNGVVPK
HHHHHHHHCCCCCCC		33.7623954790
603AcetylationKYNGVVPKFDPKKVS
HCCCCCCCCCHHHCC		51.2824489116
628AcetylationEILSNYVKEMELGHE
HHHHHHHHHHHCCCC		40.7724489116
657AcetylationNQFLQENKLDNTLFS
HHHHHHCCCCCCCCC		57.3724489116
701AcetylationEIGEKINKMLNAPAL
HHHHHHHHHHCCCCC		48.5124489116
737AcetylationLFQRIDEKKIDEWRA
HHHHHCHHHHHHHHH		51.8124489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYMC_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYMC_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYMC_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARC1_YEASTARC1physical
14759368
SYMC_YEASTMES1physical
14759368
SYEC_YEASTGUS1physical
14759368
SYEC_YEASTGUS1physical
16554755
HIF1_YEASTHIF1physical
16554755
GYS2_YEASTGSY2physical
16554755
ARC1_YEASTARC1physical
16429126
SYEC_YEASTGUS1physical
16429126
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
19536198
PDX3_YEASTPDX3genetic
21623372
THRC_YEASTTHR4genetic
21623372
HTD2_YEASTHTD2genetic
21623372
TPS2_YEASTTPS2genetic
21623372
CYS3_YEASTCYS3genetic
21623372
DCOR_YEASTSPE1genetic
21623372
ADH3_YEASTADH3genetic
21623372
CEM1_YEASTCEM1genetic
21623372
ADK_YEASTADO1genetic
21623372
ATP5E_YEASTATP15genetic
21623372
ACON_YEASTACO1genetic
21623372
ARC1_YEASTARC1physical
23161686
LTE1_YEASTLTE1genetic
27708008
SNF5_YEASTSNF5genetic
27708008
IPT1_YEASTIPT1genetic
27708008
DHAS_YEASTHOM2genetic
27708008
DAL81_YEASTDAL81genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
ALAM_YEASTALT1genetic
27708008
PHO80_YEASTPHO80genetic
27708008
BUD21_YEASTBUD21genetic
27708008
OSW1_YEASTOSW1genetic
27708008
PEX22_YEASTPEX22genetic
27708008
SLA1_YEASTSLA1genetic
27708008
TPS1_YEASTTPS1genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
AIM4_YEASTAIM4genetic
27708008
CHK1_YEASTCHK1genetic
27708008
BPH1_YEASTBPH1genetic
27708008
YCY0_YEASTYCR090Cgenetic
27708008
RPN4_YEASTRPN4genetic
27708008
GPR1_YEASTGPR1genetic
27708008
BRE1_YEASTBRE1genetic
27708008
OST4_YEASTOST4genetic
27708008
MNN10_YEASTMNN10genetic
27708008
CGR1_YEASTCGR1genetic
27708008
MON1_YEASTMON1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
XRN1_YEASTXRN1genetic
27708008
YGS6_YEASTYGL176Cgenetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
NMD2_YEASTNMD2genetic
27708008
STB5_YEASTSTB5genetic
27708008
VPS53_YEASTVPS53genetic
27708008
GSH1_YEASTGSH1genetic
27708008
YJ09_YEASTYJR039Wgenetic
27708008
IXR1_YEASTIXR1genetic
27708008
ZRT3_YEASTZRT3genetic
27708008
XPOT_YEASTLOS1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
CSF1_YEASTCSF1genetic
27708008
SWI6_YEASTSWI6genetic
27708008
RL37A_YEASTRPL37Agenetic
27708008
TSR2_YEASTTSR2genetic
27708008
ERG6_YEASTERG6genetic
27708008
UBX2_YEASTUBX2genetic
27708008
VPS9_YEASTVPS9genetic
27708008
SUB1_YEASTSUB1genetic
27708008
PKR1_YEASTPKR1genetic
27708008
NUP53_YEASTNUP53genetic
27708008
RM44_YEASTMRPL44genetic
27708008
GAS1_YEASTGAS1genetic
27708008
HRB1_YEASTHRB1genetic
27708008
EOS1_YEASTEOS1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
BRE5_YEASTBRE5genetic
27708008
SIN3_YEASTSIN3genetic
27708008
VPS68_YEASTVPS68genetic
27708008
HPF1_YEASTHPF1genetic
27708008
LEO1_YEASTLEO1genetic
27708008
PNT1_YEASTPNT1genetic
27708008
VPH1_YEASTVPH1genetic
27708008
PMA2_YEASTPMA2genetic
27708008
ELP4_YEASTELP4genetic
27708008
PEX25_YEASTPEX25genetic
27708008
YP113_YEASTYPL113Cgenetic
27708008
NIP80_YEASTNIP100genetic
27708008
FLC1_YEASTFLC1genetic
27708008
GYP5_YEASTGYP5genetic
27708008
QCR2_YEASTQCR2genetic
27708008
RSP5_YEASTRSP5genetic
27811238
PMP1_YEASTPMP1physical
26404137
ARC1_YEASTARC1physical
27330079
RPB1_YEASTRPO21physical
25453761
RPB7_YEASTRPB7physical
25453761
ARC1_YEASTARC1physical
25453761
SYEC_YEASTGUS1physical
25453761
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYMC_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Cytoplasmic methionyl-tRNA synthetase from Bakers' yeast. A monomerwith a post-translationally modified N-terminus.";
Fasiolo F., Gibson B.W., Walter P., Chatton B., Biemann K.,Boulanger Y.;
J. Biol. Chem. 260:15571-15576(1985).
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, CLEAVAGEOF INITIATOR METHIONINE, AND ACETYLATION AT SER-2.
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373, AND MASSSPECTROMETRY.

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