HIF1_YEAST - dbPTM
HIF1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HIF1_YEAST
UniProt AC Q12373
Protein Name HAT1-interacting factor 1
Gene Name HIF1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 385
Subcellular Localization Nucleus .
Protein Description Histone H3 and H4 specific chaperone component of the nuclear histone acetyltransferase B (HAT-B) complex. Involved in chromatin assembly and telomere silencing..
Protein Sequence MKLRAEDVLANGTSRHKVQIDMERQVQIAKDLLAQKKFLEAAKRCQQTLDSLPKDGLLPDPELFTIFAQAVYNMEVQNSGNLFGDALLAGDDGSGSESESEPESDVSNGEEGNENGQTEIPNSRMFQFDQEEEDLTGDVDSGDSEDSGEGSEEEEENVEKEEERLALHELANFSPANEHDDEIEDVSQLRKSGFHIYFENDLYENALDLLAQALMLLGRPTADGQSLTENSRLRIGDVYILMGDIEREAEMFSRAIHHYLKALGYYKTLKPAEQVTEKVIQAEFLVCDALRWVDQVPAKDKLKRFKHAKALLEKHMTTRPKDSELQQARLAQIQDDIDEVQENQQHGSKRPLSQPTTSIGFPALEKPLGDFNDLSQLVKKKPRRH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
136PhosphorylationDQEEEDLTGDVDSGD
CCCCCCCCCCCCCCC		43.5919795423
141PhosphorylationDLTGDVDSGDSEDSG
CCCCCCCCCCCCCCC		44.3319795423
144PhosphorylationGDVDSGDSEDSGEGS
CCCCCCCCCCCCCCC		46.9919795423
147PhosphorylationDSGDSEDSGEGSEEE
CCCCCCCCCCCCHHH		34.3919795423
151PhosphorylationSEDSGEGSEEEEENV
CCCCCCCCHHHHHHH		37.2219795423
174PhosphorylationLHELANFSPANEHDD
HHHHHCCCCCCCCCC		23.9422369663
187PhosphorylationDDEIEDVSQLRKSGF
CCHHHCHHHHHHCCC		35.5022369663
349AcetylationENQQHGSKRPLSQPT
HHHHCCCCCCCCCCC		63.7325381059
353PhosphorylationHGSKRPLSQPTTSIG
CCCCCCCCCCCCCCC		36.4820377248
356PhosphorylationKRPLSQPTTSIGFPA
CCCCCCCCCCCCCCC		26.0720377248
357PhosphorylationRPLSQPTTSIGFPAL
CCCCCCCCCCCCCCC		25.6530377154
358PhosphorylationPLSQPTTSIGFPALE
CCCCCCCCCCCCCCC		24.1621440633
366AcetylationIGFPALEKPLGDFND
CCCCCCCCCCCCCCH		46.5224489116
375PhosphorylationLGDFNDLSQLVKKKP
CCCCCHHHHHHHHCC		25.0829136822
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HIF1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HIF1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HIF1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC48_YEASTCDC48physical
16554755
RV167_YEASTRVS167physical
16554755
YJ9S_YEASTYJR154Wphysical
16554755
CORO_YEASTCRN1physical
16554755
TRI1_YEASTTRI1physical
16554755
HAT1_YEASTHAT1physical
16554755
HAT1_YEASTHAT1physical
16429126
HAT2_YEASTHAT2physical
16429126
H4_YEASTHHF1physical
16429126
HIF1_YEASTHIF1physical
17880717
HAT2_YEASTHAT2physical
17880717
HAT1_YEASTHAT1physical
17880717
H4_YEASTHHF1physical
17880717
H4_YEASTHHF1physical
18373695
HAT2_YEASTHAT2physical
18719252
SSB1_YEASTSSB1physical
19536198
HAT1_YEASTHAT1physical
20953179
HAT2_YEASTHAT2physical
20953179
H3_YEASTHHT1physical
20953179
H4_YEASTHHF1physical
20953179
H31_BOVINHIST1H3Cphysical
24946827
H2B1K_BOVINHIST1H2BNphysical
24946827
H2A2C_BOVINHIST2H2ACphysical
24946827
H4_BOVINH4physical
24946827
H2A1_YEASTHTA1physical
24946827
H2A2_YEASTHTA2physical
24946827
H2B1_YEASTHTB1physical
24946827
H2B2_YEASTHTB2physical
24946827
H3_YEASTHHT1physical
24946827
H4_YEASTHHF1physical
24946827
DBF4_YEASTDBF4genetic
27708008
CDC37_YEASTCDC37genetic
27708008
MOB2_YEASTMOB2genetic
27708008
PRP18_YEASTPRP18genetic
27708008
SMD1_YEASTSMD1genetic
27708008
ZPR1_YEASTZPR1genetic
27708008
MOB1_YEASTMOB1genetic
27708008
ARP4_YEASTARP4genetic
27708008
FNTA_YEASTRAM2genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
ROT1_YEASTROT1genetic
27708008
RIB2_YEASTRIB2genetic
27708008
PAT1_YEASTPAT1genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
LSM6_YEASTLSM6genetic
27708008
LSM1_YEASTLSM1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
SNC2_YEASTSNC2genetic
27708008
H2A1_YEASTHTA1physical
27618665
H2B1_YEASTHTB1physical
27618665
H3_YEASTHHT1physical
27618665
H4_YEASTHHF1physical
27618665
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HIF1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174, AND MASSSPECTROMETRY.

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