HAT1_YEAST - dbPTM
HAT1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HAT1_YEAST
UniProt AC Q12341
Protein Name Histone acetyltransferase type B catalytic subunit
Gene Name HAT1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 374
Subcellular Localization Cytoplasm. Nucleus.
Protein Description Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of free histone H4 in the cytoplasm. The complex is also found in the nucleus, however it is not certain that it modifies histone H4 when packaged in chromatin. Histone H4 'Lys-12' acetylation is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair..
Protein Sequence MSANDFKPETWTSSANEALRVSIVGENAVQFSPLFTYPIYGDSEKIYGYKDLIIHLAFDSVTFKPYVNVKYSAKLGDDNIVDVEKKLLSFLPKDDVIVRDEAKWVDCFAEERKTHNLSDVFEKVSEYSLNGEEFVVYKSSLVDDFARRMHRRVQIFSLLFIEAANYIDETDPSWQIYWLLNKKTKELIGFVTTYKYWHYLGAKSFDEDIDKKFRAKISQFLIFPPYQNKGHGSCLYEAIIQSWLEDKSITEITVEDPNEAFDDLRDRNDIQRLRKLGYDAVFQKHSDLSDEFLESSRKSLKLEERQFNRLVEMLLLLNNSPSFELKVKNRLYIKNYDALDQTDPEKAREALQNSFILVKDDYRRIIESINKSQG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationANDFKPETWTSSANE
CCCCCCCCCCCCHHH		42.4430377154
12PhosphorylationDFKPETWTSSANEAL
CCCCCCCCCCHHHHE		21.8930377154
13PhosphorylationFKPETWTSSANEALR
CCCCCCCCCHHHHEE		21.0030377154
85AcetylationDNIVDVEKKLLSFLP
CCEEEHHHHHHHCCC		48.8724489116
93AcetylationKLLSFLPKDDVIVRD
HHHHCCCCCCEEEEC		69.5724489116
334UbiquitinationVKNRLYIKNYDALDQ
EECCEEECCCCCCCC		35.5823749301
354PhosphorylationAREALQNSFILVKDD
HHHHHHHCEEEEEHH		10.7425752575
372PhosphorylationIIESINKSQG-----
HHHHHHHHCC-----		35.3323749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HAT1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HAT1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HAT1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HAT2_YEASTHAT2physical
11805826
HIF1_YEASTHIF1physical
11805826
EIF3C_YEASTNIP1physical
11805826
EIF3B_YEASTPRT1physical
11805826
EIF3A_YEASTRPG1physical
11805826
HIF1_YEASTHIF1physical
14761951
H2B2_YEASTHTB2physical
16554755
H2A2_YEASTHTA2physical
16554755
PP2C4_YEASTPTC4physical
16554755
YRA1_YEASTYRA1physical
16554755
SPT3_YEASTSPT3physical
16554755
SET1_YEASTSET1physical
16554755
SWE1_YEASTSWE1physical
16554755
YJ9S_YEASTYJR154Wphysical
16554755
AHP1_YEASTAHP1physical
16554755
STM1_YEASTSTM1physical
16554755
RL37A_YEASTRPL37Aphysical
16554755
ABF2_YEASTABF2physical
16554755
ORC5_YEASTORC5physical
16554755
ASE1_YEASTASE1physical
16554755
ORC4_YEASTORC4physical
16554755
HSC82_YEASTHSC82physical
16554755
HAT2_YEASTHAT2physical
16429126
HIF1_YEASTHIF1physical
16429126
HAT2_YEASTHAT2physical
17880717
ORC1_YEASTORC1physical
17880717
ORC2_YEASTORC2physical
17880717
ORC3_YEASTORC3physical
17880717
ORC4_YEASTORC4physical
17880717
ORC5_YEASTORC5physical
17880717
ORC6_YEASTORC6physical
17880717
HIF1_YEASTHIF1physical
17880717
HAT1_YEASTHAT1physical
17880717
H4_YEASTHHF1physical
17880717
MCM2_YEASTMCM2genetic
17880717
IMB4_YEASTKAP123physical
17507373
ATPG_YEASTATP3genetic
18676811
BUR2_YEASTBUR2genetic
18676811
CISY3_YEASTCIT3genetic
18676811
EAF3_YEASTEAF3genetic
18676811
GOSR1_YEASTGOS1genetic
18676811
HST2_YEASTHST2genetic
18676811
MHR1_YEASTMHR1genetic
18676811
RM06_YEASTMRPL6genetic
18676811
PGPS1_YEASTPGS1genetic
18676811
HSP7Q_YEASTSSQ1genetic
18676811
GEP5_YEASTGEP5genetic
18676811
PVH1_YEASTYVH1genetic
18676811
H4_YEASTHHF1physical
18373695
H3_YEASTHHT1genetic
18753131
SSB2_YEASTSSB2physical
19536198
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
19536198
REI1_YEASTREI1genetic
21127252
KCS1_YEASTKCS1genetic
21127252
MET18_YEASTMET18genetic
21127252
RTG3_YEASTRTG3genetic
21127252
HIF1_YEASTHIF1genetic
21998594
H2A4_CHICKHIST1H2A4physical
23775086
H4_CHICKHIST1H47physical
23775086
HAT2_YEASTHAT2physical
24835250
H4_YEASTHHF1physical
24835250
GPR1_YEASTGPR1genetic
27708008
NHX1_YEASTNHX1genetic
27453043
CSK22_YEASTCKA2genetic
27453043
INO2_YEASTINO2genetic
27453043
IRA2_YEASTIRA2genetic
27453043
DCOR_YEASTSPE1genetic
27453043
INO4_YEASTINO4genetic
27453043
RAS2_YEASTRAS2genetic
27453043
LSM1_YEASTLSM1genetic
27453043
RGM1_YEASTRGM1genetic
27453043
SCH9_YEASTSCH9genetic
27453043
DCAM_YEASTSPE2genetic
27453043
COQ6_YEASTCOQ6genetic
27453043
TRIM2_HUMANTRIM2physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HAT1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND MASSSPECTROMETRY.

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