HST2_YEAST - dbPTM
HST2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HST2_YEAST
UniProt AC P53686
Protein Name NAD-dependent protein deacetylase HST2
Gene Name HST2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 357
Subcellular Localization Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm, but is largely cytoplasmic owing to efficient nuclear export. Nuclear exclusion is mediated by the exportin CRM1.
Protein Description NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export..
Protein Sequence MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSVSTASTE
------CCCCCCCHH		25.4422814378
2Phosphorylation------MSVSTASTE
------CCCCCCCHH		25.4422369663
4Phosphorylation----MSVSTASTEMS
----CCCCCCCHHHH		15.7922369663
5Phosphorylation---MSVSTASTEMSV
---CCCCCCCHHHHH		23.5919823750
7Phosphorylation-MSVSTASTEMSVRK
-CCCCCCCHHHHHHH		25.6219823750
8PhosphorylationMSVSTASTEMSVRKI
CCCCCCCHHHHHHHH		32.9919823750
11PhosphorylationSTASTEMSVRKIAAH
CCCCHHHHHHHHHHH		16.7319823750
87PhosphorylationYTLAKELYPGNFRPS
HHHHHHHCCCCCCHH		15.3619823750
94PhosphorylationYPGNFRPSKFHYLLK
CCCCCCHHHHHHHHH		43.6319823750
98PhosphorylationFRPSKFHYLLKLFQD
CCHHHHHHHHHHHCC		19.5019823750
110AcetylationFQDKDVLKRVYTQNI
HCCHHHHHHHHHCCH		39.4024489116
114PhosphorylationDVLKRVYTQNIDTLE
HHHHHHHHCCHHHHH		16.5728889911
251PhosphorylationRVLCNLETVGDFKAN
HHHCCCCCCCCCCCC		32.7125704821
301PhosphorylationQGGMGDNSKEQLLEI
CCCCCCCCHHHHHHH		42.1622369663
316PhosphorylationVHDLENLSLDQSEHE
HHHHHHCCCCHHHHH		41.2922369663
320PhosphorylationENLSLDQSEHESADK
HHCCCCHHHHHCCCH		40.3622369663
324PhosphorylationLDQSEHESADKKDKK
CCHHHHHCCCHHHHH		43.6122369663
340PhosphorylationQRLNGHDSDEDGASN
HHHCCCCCCCCCCCC		36.9122369663
346PhosphorylationDSDEDGASNSSSSQK
CCCCCCCCCCHHHHH		42.6522369663
348PhosphorylationDEDGASNSSSSQKAA
CCCCCCCCHHHHHHH		29.1522369663
349PhosphorylationEDGASNSSSSQKAAK
CCCCCCCHHHHHHHH		37.9522369663
350PhosphorylationDGASNSSSSQKAAKE
CCCCCCHHHHHHHHC		36.2922369663
351PhosphorylationGASNSSSSQKAAKE-
CCCCCHHHHHHHHC-		37.3322369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HST2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HST2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HST2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LSM6_YEASTLSM6genetic
17314980
YME1_YEASTYME1genetic
20141839
BUD21_YEASTBUD21genetic
20141839
TIM18_YEASTTIM18genetic
20141839
VPS8_YEASTVPS8genetic
20141839
SIR1_YEASTSIR1genetic
20141839
SIT1_YEASTSIT1genetic
20141839
HBT1_YEASTHBT1genetic
20141839
GIS4_YEASTGIS4genetic
20141839
RL8B_YEASTRPL8Bgenetic
20141839
SRO7_YEASTSRO7genetic
20141839
SNT1_YEASTSNT1genetic
20141839
SYG_YEASTGRS1genetic
20141839
VAM3_YEASTVAM3genetic
20141839
PP2A4_YEASTPPG1genetic
20141839
CTF4_YEASTCTF4genetic
20141839
RL16B_YEASTRPL16Bgenetic
20141839
SPS4_YEASTSPS4genetic
20141839
RT109_YEASTRTT109physical
21606491
H3_YEASTHHT1physical
22474337
ESA1_YEASTESA1genetic
25381059
CDC37_YEASTCDC37genetic
27708008
SMT3_YEASTSMT3genetic
27708008
SMD1_YEASTSMD1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HST2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340, AND MASSSPECTROMETRY.

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