RL8B_YEAST - dbPTM
RL8B_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RL8B_YEAST
UniProt AC P29453
Protein Name 60S ribosomal protein L8-B {ECO:0000303|PubMed:9559554}
Gene Name RPL8B {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 256
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MAPGKKVAPAPFGAKSTKSNKAKNPLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRLQRQKKILSIRLKVPPTIAQFQYTLDRNTAAETFKLFNKYRPETAAEKKERLTKEAAAIAEGKSKQDASPKPYAVKYGLNHVVSLIENKKAKLVLIANDVDPIELVVFLPALCKKMGVPYAIIKGKARLGTLVNQKTSAVAALTEVRAEDEAALAKLVSTIDANFADKYDEVKKHWGGGILGNKAQAKMDKRAKTSDSA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Ubiquitination--MAPGKKVAPAPFG
--CCCCCCCCCCCCC		49.9323749301
15UbiquitinationAPAPFGAKSTKSNKA
CCCCCCCCCCCCCCC		60.0622817900
15MethylationAPAPFGAKSTKSNKA
CCCCCCCCCCCCCCC		60.0620137074
16PhosphorylationPAPFGAKSTKSNKAK
CCCCCCCCCCCCCCC		40.3021440633
17PhosphorylationAPFGAKSTKSNKAKN
CCCCCCCCCCCCCCC		37.4721082442
18UbiquitinationPFGAKSTKSNKAKNP
CCCCCCCCCCCCCCC		60.1522817900
18AcetylationPFGAKSTKSNKAKNP
CCCCCCCCCCCCCCC		60.1525381059
23AcetylationSTKSNKAKNPLTHST
CCCCCCCCCCCCCCC		61.7923572591
23UbiquitinationSTKSNKAKNPLTHST
CCCCCCCCCCCCCCC		61.7915699485
27PhosphorylationNKAKNPLTHSTPKNF
CCCCCCCCCCCCCCC		18.2921551504
29PhosphorylationAKNPLTHSTPKNFGI
CCCCCCCCCCCCCCC		40.9621440633
30PhosphorylationKNPLTHSTPKNFGIG
CCCCCCCCCCCCCCC		30.5821440633
32UbiquitinationPLTHSTPKNFGIGQA
CCCCCCCCCCCCCCC		66.0624961812
43MethylationIGQAVQPKRNLSRYV
CCCCCCCCCCHHHHC		36.51-
43UbiquitinationIGQAVQPKRNLSRYV
CCCCCCCCCCHHHHC		36.5115699485
432-HydroxyisobutyrylationIGQAVQPKRNLSRYV
CCCCCCCCCCHHHHC		36.51-
49PhosphorylationPKRNLSRYVKWPEYV
CCCCHHHHCCHHHHH		11.7321440633
51UbiquitinationRNLSRYVKWPEYVRL
CCHHHHCCHHHHHHH		48.3623749301
632-HydroxyisobutyrylationVRLQRQKKILSIRLK
HHHHHHCCEEEEEEE		40.31-
66PhosphorylationQRQKKILSIRLKVPP
HHHCCEEEEEEECCC		14.7721440633
70UbiquitinationKILSIRLKVPPTIAQ
CEEEEEEECCCCEEE		42.7323749301
92UbiquitinationNTAAETFKLFNKYRP
CCHHHHHHHHHHHCH		60.6423749301
922-HydroxyisobutyrylationNTAAETFKLFNKYRP
CCHHHHHHHHHHHCH		60.64-
96UbiquitinationETFKLFNKYRPETAA
HHHHHHHHHCHHHHH		34.9922817900
1052-HydroxyisobutyrylationRPETAAEKKERLTKE
CHHHHHHHHHHHHHH		56.03-
106UbiquitinationPETAAEKKERLTKEA
HHHHHHHHHHHHHHH		39.3022817900
111AcetylationEKKERLTKEAAAIAE
HHHHHHHHHHHHHHC		50.3624489116
111UbiquitinationEKKERLTKEAAAIAE
HHHHHHHHHHHHHHC		50.3623749301
1202-HydroxyisobutyrylationAAAIAEGKSKQDASP
HHHHHCCCCCCCCCC		46.08-
120UbiquitinationAAAIAEGKSKQDASP
HHHHHCCCCCCCCCC		46.0823749301
121PhosphorylationAAIAEGKSKQDASPK
HHHHCCCCCCCCCCC		46.5422369663
122UbiquitinationAIAEGKSKQDASPKP
HHHCCCCCCCCCCCC		56.5423749301
126PhosphorylationGKSKQDASPKPYAVK
CCCCCCCCCCCHHHH		41.5720377248
130PhosphorylationQDASPKPYAVKYGLN
CCCCCCCHHHHHCHH		30.1025521595
133UbiquitinationSPKPYAVKYGLNHVV
CCCCHHHHHCHHHHH		25.9817644757
134PhosphorylationPKPYAVKYGLNHVVS
CCCHHHHHCHHHHHH		21.9025521595
141PhosphorylationYGLNHVVSLIENKKA
HCHHHHHHHHHCCCC		23.6521440633
146SuccinylationVVSLIENKKAKLVLI
HHHHHHCCCCEEEEE		41.1223954790
146AcetylationVVSLIENKKAKLVLI
HHHHHHCCCCEEEEE		41.1224489116
146UbiquitinationVVSLIENKKAKLVLI
HHHHHHCCCCEEEEE		41.1217644757
147UbiquitinationVSLIENKKAKLVLIA
HHHHHCCCCEEEEEE		63.4417644757
149UbiquitinationLIENKKAKLVLIAND
HHHCCCCEEEEEECC		48.2717644757
171UbiquitinationVFLPALCKKMGVPYA
HHHHHHHHHHCCCEE		46.7917644757
172UbiquitinationFLPALCKKMGVPYAI
HHHHHHHHHCCCEEE		39.6317644757
181AcetylationGVPYAIIKGKARLGT
CCCEEEEECCHHHHH		48.5224489116
188PhosphorylationKGKARLGTLVNQKTS
ECCHHHHHHHCCHHH		31.9321440633
193UbiquitinationLGTLVNQKTSAVAAL
HHHHHCCHHHHHHHH		38.9623749301
194PhosphorylationGTLVNQKTSAVAALT
HHHHCCHHHHHHHHH		16.5021440633
213UbiquitinationEDEAALAKLVSTIDA
HCHHHHHHHHHHHCH		50.7224961812
216PhosphorylationAALAKLVSTIDANFA
HHHHHHHHHHCHHHH		30.0417563356
217PhosphorylationALAKLVSTIDANFAD
HHHHHHHHHCHHHHH		18.5224961812
225UbiquitinationIDANFADKYDEVKKH
HCHHHHHCHHHHHHH		51.6915699485
2252-HydroxyisobutyrylationIDANFADKYDEVKKH
HCHHHHHCHHHHHHH		51.69-
230UbiquitinationADKYDEVKKHWGGGI
HHCHHHHHHHCCCCC		36.5515699485
231UbiquitinationDKYDEVKKHWGGGIL
HCHHHHHHHCCCCCC		50.1715699485
241UbiquitinationGGGILGNKAQAKMDK
CCCCCCHHHHHHHHH		39.8315699485
241MethylationGGGILGNKAQAKMDK
CCCCCCHHHHHHHHH		39.83-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RL8B_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RL8B_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RL8B_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
USA1_YEASTUSA1physical
18719252
SSB1_YEASTSSB1physical
19536198
CSG2_YEASTCSG2genetic
20093466
UBS1_YEASTUBS1genetic
20093466
BEM1_YEASTBEM1genetic
20093466
DPB3_YEASTDPB3genetic
20093466
PNPP_YEASTPHO13genetic
20093466
TMA17_YEASTTMA17genetic
20093466
TRPE_YEASTTRP2genetic
20093466
UBP3_YEASTUBP3genetic
20093466
RAD4_YEASTRAD4genetic
20093466
CTU1_YEASTNCS6genetic
20093466
RS25A_YEASTRPS25Agenetic
20093466
PMT6_YEASTPMT6genetic
20093466
RL8A_YEASTRPL8Agenetic
20093466
THP2_YEASTTHP2genetic
20093466
OYE2_YEASTOYE2genetic
20093466
IME2_YEASTIME2genetic
20093466
MSN2_YEASTMSN2genetic
20093466
SAS2_YEASTSAS2genetic
20093466
VPS27_YEASTVPS27genetic
20093466
BRE5_YEASTBRE5genetic
20093466
NOP12_YEASTNOP12genetic
20093466
DDC1_YEASTDDC1genetic
20093466
SVL3_YEASTSVL3genetic
20093466
MED1_YEASTMED1genetic
20093466
ISR1_YEASTISR1genetic
20093466
CND2_YEASTBRN1genetic
27708008
UBC3_YEASTCDC34genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
RMRP_YEASTSNM1genetic
27708008
SWC4_YEASTSWC4genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
CWC16_YEASTYJU2genetic
27708008
NOP56_YEASTNOP56genetic
27708008
TAD3_YEASTTAD3genetic
27708008
NNK1_YEASTNNK1genetic
27708008
OAF3_YEASTOAF3genetic
27708008
CDC27_YEASTCDC27genetic
27708008
TECR_YEASTTSC13genetic
27708008
GLE1_YEASTGLE1genetic
27708008
RLI1_YEASTRLI1genetic
27708008
ERF3_YEASTSUP35genetic
27708008
PCF11_YEASTPCF11genetic
27708008
RSP5_YEASTRSP5genetic
27708008
RNA15_YEASTRNA15genetic
27708008
PTI1_YEASTPTI1genetic
27708008
EXO70_YEASTEXO70genetic
27708008
KRE9_YEASTKRE9genetic
27708008
ESS1_YEASTESS1genetic
27708008
FIP1_YEASTFIP1genetic
27708008
FNTA_YEASTRAM2genetic
27708008
MAK11_YEASTMAK11genetic
27708008
RRN3_YEASTRRN3genetic
27708008
CFT2_YEASTCFT2genetic
27708008
PWP1_YEASTPWP1genetic
27708008
ERO1_YEASTERO1genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
DBP6_YEASTDBP6genetic
27708008
HRP1_YEASTHRP1genetic
27708008
SGT1_YEASTSGT1genetic
27708008
TYSY_YEASTCDC21genetic
27708008
SMP3_YEASTSMP3genetic
27708008
BUR1_YEASTSGV1genetic
27708008
CSG2_YEASTCSG2genetic
27708008
RS25A_YEASTRPS25Agenetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
THP2_YEASTTHP2genetic
27708008
SPO22_YEASTSPO22genetic
27708008
TOK1_YEASTTOK1genetic
27708008
YAK1_YEASTYAK1genetic
27708008
CTK1_YEASTCTK1genetic
27708008
PYRD_YEASTURA1genetic
27708008
KTR2_YEASTKTR2genetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
BRE5_YEASTBRE5genetic
27708008
NOP12_YEASTNOP12genetic
27708008
RRP6_YEASTRRP6genetic
27708008
ISR1_YEASTISR1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RL8B_YEAST

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Related Literatures of Post-Translational Modification

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