IME2_YEAST - dbPTM
IME2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IME2_YEAST
UniProt AC P32581
Protein Name Meiosis induction protein kinase IME2/SME1
Gene Name IME2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 645
Subcellular Localization
Protein Description Protein kinase which is essential for the initiation of meiosis and sporulation..
Protein Sequence MVEKRSRQSSSSGSEFSVPPDVDNPPLSIPLKTLSDRYQLIEKLGAGSFGCVTLAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYITKTQGVVAIKTMMTKLHTLQDYTRVREIKFILAIPANDHLIQIFEVFIDSENYQLHIVMECMEQNLYQMMKHRRRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFGLARHVENKNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEVTVFRALFPGANEIDQIWKILEVLGTPIKRSDFVNTNHITAPPPGGFWDDASNLVHKLNLKLPYVEGSSLDHLLSSSQLSDLSEVVKKCLRWDPNERATAQELCEMPFFENTVASQVDARGNVTNTEQALIFAGINPVATNTKPIYFNSSTKLPAETESNDIDISNNDHDSHAMCSPTLNQEKLTLVEFLNEFVEEDNDDHSIPDVGTDSTISDSIDETELSKEIRNNLALCQLPDEEVLDHSLSNIRQLTNDIEIINKDEADNMEQLFFDLEIPEKDEFQRKQPFNEHADIDEDIVLPYVNNSNYTHTDRSHHRGDNVLGDASLGDSFNSMPDFTPRNFLIPTLKKSREKFEPHLSNSNQHFGNVTF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
241PhosphorylationHVENKNPYTAYVSTR
CCCCCCCCCEEEECC		17.2527214570
242PhosphorylationVENKNPYTAYVSTRW
CCCCCCCCEEEECCC		16.8716684773
244PhosphorylationNKNPYTAYVSTRWYR
CCCCCCEEEECCCCC		6.2716684773
520PhosphorylationDEEVLDHSLSNIRQL
CHHHHHHCHHHHHHH		32.9116684773
625PhosphorylationLIPTLKKSREKFEPH
CCCHHHHHHHHCCCC		44.0516684773
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseGRR1P24814
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IME2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IME2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TCPB_YEASTCCT2physical
11805837
TCPA_YEASTTCP1physical
11805837
GPA2_YEASTGPA2physical
10454558
IME1_YEASTIME1physical
11884593
CDC6_YEASTCDC6physical
15004237
NDT80_YEASTNDT80physical
14680970
NDT80_YEASTNDT80physical
12242283
RFA2_YEASTRFA2physical
14634024
IME2_YEASTIME2physical
14612412
NDT80_YEASTNDT80physical
14612412
NDT80_YEASTNDT80physical
12783856
NDT80_YEASTNDT80genetic
12783856
CDK1_YEASTCDC28genetic
11779796
IDS2_YEASTIDS2genetic
7565676
SIC1_YEASTSIC1genetic
9743499
RFA2_YEASTRFA2physical
16294044
HFI1_YEASTHFI1physical
16319894
PP2C1_YEASTPTC1physical
16319894
PFKA1_YEASTPFK1physical
16319894
SRPR_YEASTSRP101physical
16319894
SRO7_YEASTSRO7physical
16319894
FCY21_YEASTFCY21physical
16319894
KKQ8_YEASTKKQ8physical
16319894
KU70_YEASTYKU70physical
16319894
PAH1_YEASTPAH1physical
16319894
AB140_YEASTABP140physical
16319894
RIM4_YEASTRIM4physical
16319894
YMC1_YEASTYMC1physical
16319894
ATP14_YEASTATP14physical
16319894
YN11A_YEASTYNL284C-Aphysical
16319894
YD21A_YEASTYDR034C-Cphysical
16319894
SEC2_YEASTSEC2physical
16319894
UGA4_YEASTUGA4physical
16319894
RS24A_YEASTRPS24Bphysical
16319894
RS24B_YEASTRPS24Bphysical
16319894
DMA2_YEASTDMA2physical
16319894
SYEC_YEASTGUS1physical
16319894
BUD27_YEASTBUD27physical
16319894
YP150_YEASTYPL150Wphysical
16319894
PNPP_YEASTPHO13physical
16319894
ATIF_YEASTINH1physical
16319894
VHS2_YEASTVHS2physical
16319894
SAS10_YEASTSAS10physical
16319894
EF1A_YEASTTEF2physical
16319894
SYA_YEASTALA1physical
16319894
SLA1_YEASTSLA1physical
16319894
SYKM_YEASTMSK1physical
16319894
SKG1_YEASTSKG1physical
16319894
YMD7_YEASTYML037Cphysical
16319894
NDJ1_YEASTNDJ1physical
16319894
YP013_YEASTCMR3physical
16319894
DFM1_YEASTDFM1physical
16319894
RRP5_YEASTRRP5physical
16319894
IST2_YEASTIST2physical
16319894
PRM10_YEASTPRM10physical
16319894
HPH2_YEASTFRT2physical
16319894
MLF3_YEASTMLF3physical
16319894
UBP10_YEASTUBP10physical
16319894
CWC25_YEASTCWC25physical
16319894
AIM3_YEASTAIM3physical
16319894
YG36_YEASTYGR126Wphysical
16319894
ISA2_YEASTISA2physical
16319894
NBP1_YEASTNBP1physical
16319894
SPT16_YEASTSPT16physical
16319894
YG3A_YEASTYGR130Cphysical
16319894
RSA3_YEASTRSA3physical
16319894
UBC5_YEASTUBC5physical
16319894
SHE3_YEASTSHE3physical
16319894
CRZ1_YEASTCRZ1physical
16319894
YM11A_YEASTYML045W-Aphysical
16319894
YAP6_YEASTYAP6physical
16319894
BDF2_YEASTBDF2physical
16319894
HDA2_YEASTHDA2physical
16319894
CDC13_YEASTCDC13physical
16319894
MST27_YEASTMST27physical
16319894
REXO1_YEASTRNH70physical
16319894
SIC1_YEASTSIC1physical
16776651
CDK2_HUMANCDK2genetic
19197163
CDK4_HUMANCDK4genetic
19197163
ACM1_YEASTACM1physical
20489023
ASK10_YEASTASK10physical
20489023
CDH1_YEASTCDH1physical
20489023
KOG1_YEASTKOG1physical
20489023
LST8_YEASTLST8physical
20489023
MUB1_YEASTMUB1physical
20489023
SIS1_YEASTSIS1physical
20489023
TGL1_YEASTTGL1physical
20489023
VID30_YEASTVID30physical
20489023
RGC1_YEASTRGC1physical
20489023
RAD53_YEASTRAD53genetic
21099355
REI1_YEASTREI1genetic
21127252
KCS1_YEASTKCS1genetic
21127252
RTG3_YEASTRTG3genetic
21127252
DUN1_YEASTDUN1genetic
21127252
UPC2_YEASTUPC2genetic
21127252
SUM1_YEASTSUM1physical
19528232
WHI5_YEASTWHI5genetic
22393365
CG21_YEASTCLB1genetic
11779796
YCT1_YEASTYCT1genetic
22282571
MSS2_YEASTMSS2genetic
22282571
YM8V_YEASTYMR295Cgenetic
22282571
BST1_YEASTBST1genetic
22282571
PAU21_YEASTPAU21genetic
22282571
PAU22_YEASTPAU21genetic
22282571
TIR4_YEASTTIR4genetic
22282571
SLX5_YEASTSLX5genetic
22282571
RLA4_YEASTRPP2Bgenetic
22282571
STE50_YEASTSTE50genetic
22282571
SAC1_YEASTSAC1genetic
22282571
IDH1_YEASTIDH1genetic
22282571
YO08A_YEASTYOR008C-Agenetic
22282571
BUD31_YEASTBUD31genetic
22282571
SIC1_YEASTSIC1physical
17137646
TBP_YEASTSPT15genetic
27708008
CDC4_YEASTCDC4genetic
27708008
GFA1_YEASTGFA1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
DBP6_YEASTDBP6genetic
27708008
SLX5_YEASTSLX5genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
THIK_YEASTPOT1genetic
27708008
LST4_YEASTLST4genetic
27708008
ERG3_YEASTERG3genetic
27708008
ENV10_YEASTENV10genetic
27708008
GBLP_YEASTASC1genetic
27708008
TIR4_YEASTTIR4genetic
27708008
VPH1_YEASTVPH1genetic
27708008
MCM2_YEASTMCM2physical
29388912
MCM3_YEASTMCM3physical
29388912
MCM4_YEASTMCM4physical
29388912
MCM5_YEASTMCM5physical
29388912
MCM6_YEASTMCM6physical
29388912
MCM7_YEASTMCM7physical
29388912
ORC1_YEASTORC1physical
29388912
ORC2_YEASTORC2physical
29388912
ORC3_YEASTORC3physical
29388912
ORC4_YEASTORC4physical
29388912
ORC5_YEASTORC5physical
29388912
ORC6_YEASTORC6physical
29388912
CDT1_YEASTTAH11physical
29388912
CDC6_YEASTCDC6physical
29388912
CDK1_YEASTCDC28genetic
29388912
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IME2_YEAST

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Related Literatures of Post-Translational Modification

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