| UniProt ID | SYKM_YEAST | |
|---|---|---|
| UniProt AC | P32048 | |
| Protein Name | Lysine--tRNA ligase, mitochondrial | |
| Gene Name | MSK1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 576 | |
| Subcellular Localization | Mitochondrion matrix. | |
| Protein Description | ||
| Protein Sequence | MNVLLKRRSLTFAPRWLWCKCRSSRSRPYSLAHAVDTSKMEATRRNGQIVKDLGRYYPSMSESALHDLCQEYKEVTIADFNERFLGNPATLHHEDNPNLLLSINGRIKSIRFSGQKIVFIDLYNGSSGLKNDTQLQLIVNYNKIGGSSEDKANFSEYMNFLKKGDYIKALGYPGFSQSRVKMLSLICNKLPIVLSVSQLPLPSRLNDETKIKSNRVVDYQLNGTQTLLVRARIIKLLRKFLDDRNFVEVETPILSSKSNGAMAKPFITSSKDFDHLELRIAPELWLKRLIISGLQKVYEIGKVFRNEGIDSTHNAEFSTLEFYETYMSMDDIVTRTEDLFKFLITNLQKFFQDTRLPVPKTFSELHLALSENNWKFRKVEFLPTLNKELGIDLMNSGLDINKPSELLKALPKDIAKKYFPSADNTGQLSSLQILNKLSDVFLEQRHCQSTLPTVIYHQPAILSPLAKTDPQNKQVTKRFEVFIKGKEYINAYEEENCPQLQLQKFLQQKQINELTGNKTETLSPVIDYQYVETMKYGMPPVGGFGLGIDRLCMLFCDKKRIEEVLPFGCVDDVNRQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | NVLLKRRSLTFAPRW CCCCCCCCCCCCCCE | 35.48 | 28889911 | |
| 219 | Phosphorylation | KSNRVVDYQLNGTQT CCCCEEEEEECCCHH | 11.86 | 29688323 | |
| 375 | Ubiquitination | ALSENNWKFRKVEFL HHHCCCCCEEEEEEH | 37.10 | 19722269 | |
| 378 | Ubiquitination | ENNWKFRKVEFLPTL CCCCCEEEEEEHHHC | 49.61 | 19722269 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYKM_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYKM_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYKM_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ARPC5_YEAST | ARC15 | physical | 16554755 | |
| CORO_YEAST | CRN1 | physical | 16554755 | |
| DRS1_YEAST | DRS1 | physical | 17707817 | |
| YSC84_YEAST | YSC84 | physical | 17707817 | |
| SYKM_YEAST | MSK1 | physical | 17707817 | |
| PIL1_YEAST | PIL1 | physical | 17707817 | |
| RPN13_YEAST | RPN13 | physical | 17707817 | |
| ALR1_YEAST | ALR1 | physical | 17707817 | |
| DOA1_YEAST | DOA1 | physical | 17707817 | |
| MTH1_YEAST | MTH1 | physical | 17707817 | |
| SEN1_YEAST | SEN1 | physical | 17707817 | |
| PT309_YEAST | PET309 | genetic | 19061648 | |
| URB1_YEAST | URB1 | genetic | 19061648 | |
| IF2M_YEAST | IFM1 | genetic | 19061648 | |
| AEP3_YEAST | AEP3 | genetic | 19061648 | |
| MAS5_YEAST | YDJ1 | physical | 19536198 | |
| HSP7F_YEAST | SSE1 | physical | 19536198 | |
| ATPG_YEAST | ATP3 | genetic | 27811238 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND MASSSPECTROMETRY. | |
