RPN13_YEAST - dbPTM
RPN13_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RPN13_YEAST
UniProt AC O13563
Protein Name 26S proteasome regulatory subunit RPN13
Gene Name RPN13
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 156
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins..
Protein Sequence MSMSSTVIKFRAGVCEYNEDSRLCTPIPVQGEIEIKPNEEEELGFWDFEWRPTEKPVGRELDPISLILIPGETMWVPIKSSKSGRIFALVFSSNERYFFWLQEKNSGNLPLNELSAKDKEIYNKMIGVLNNSSESDEEESNDEKQKAQDVDVSMQD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSMSSTVIK
------CCCCCCEEE		27.6322814378
2 (in isoform 2)Acetylation-27.6322814378
2Phosphorylation------MSMSSTVIK
------CCCCCCEEE		27.6330377154
4Phosphorylation----MSMSSTVIKFR
----CCCCCCEEEEE		18.6230377154
6Phosphorylation--MSMSSTVIKFRAG
--CCCCCCEEEEEEE		20.9530377154
97PhosphorylationVFSSNERYFFWLQEK
EEECCCEEEEEEECC		9.2823749301
106PhosphorylationFWLQEKNSGNLPLNE
EEEECCCCCCCCHHH		39.8823749301
115PhosphorylationNLPLNELSAKDKEIY
CCCHHHCCHHHHHHH		27.3923749301
117SuccinylationPLNELSAKDKEIYNK
CHHHCCHHHHHHHHH		66.9923954790
117AcetylationPLNELSAKDKEIYNK
CHHHCCHHHHHHHHH		66.9924489116
132PhosphorylationMIGVLNNSSESDEEE
HHHHHCCCCCCCHHH		34.1225521595
133PhosphorylationIGVLNNSSESDEEES
HHHHCCCCCCCHHHC		43.1522369663
135PhosphorylationVLNNSSESDEEESND
HHCCCCCCCHHHCCH		52.8822369663
140PhosphorylationSESDEEESNDEKQKA
CCCCHHHCCHHHHHH		53.5122369663
144UbiquitinationEEESNDEKQKAQDVD
HHHCCHHHHHHHHCC		61.0223749301
146UbiquitinationESNDEKQKAQDVDVS
HCCHHHHHHHHCCCC		60.1123749301
153PhosphorylationKAQDVDVSMQD----
HHHHCCCCCCC----		13.2822369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RPN13_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RPN13_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RPN13_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PRS8_YEASTRPT6physical
11029046
RPN10_YEASTRPN10physical
11029046
ECM29_YEASTECM29physical
16429126
RPN1_YEASTRPN1physical
16429126
RPN10_YEASTRPN10physical
16429126
RPN12_YEASTRPN12physical
16429126
RPN2_YEASTRPN2physical
16429126
RPN3_YEASTRPN3physical
16429126
RPN8_YEASTRPN8physical
16429126
RPN9_YEASTRPN9physical
16429126
PRS7_YEASTRPT1physical
16429126
PRS4_YEASTRPT2physical
16429126
PRS6B_YEASTRPT3physical
16429126
PRS10_YEASTRPT4physical
16429126
PRS6A_YEASTRPT5physical
16429126
PRS8_YEASTRPT6physical
16429126
RPN10_YEASTRPN10genetic
17314980
ITC1_YEASTITC1genetic
17314980
SDC1_YEASTSDC1genetic
17314980
SRB8_YEASTSRB8genetic
17314980
SLX8_YEASTSLX8genetic
17314980
JIP4_YEASTJIP4genetic
17314980
DOA1_YEASTDOA1genetic
17314980
H4_YEASTHHF1genetic
17314980
CST9_YEASTCST9genetic
17314980
RPA34_YEASTRPA34genetic
17314980
LSM6_YEASTLSM6genetic
17314980
TF3B_YEASTBRF1genetic
17314980
RPN6_YEASTRPN6genetic
17314980
BRE2_YEASTBRE2genetic
17314980
GCN20_YEASTGCN20genetic
17314980
RPN2_YEASTRPN2physical
11283351
SYKM_YEASTMSK1physical
17707817
MNT2_YEASTMNT2genetic
20093466
SDO1L_YEASTRTC3genetic
20093466
TDA11_YEASTTDA11genetic
20093466
RPN10_YEASTRPN10genetic
20093466
GZF3_YEASTGZF3genetic
20093466
SAC1_YEASTSAC1genetic
20093466
RM49_YEASTMRP49genetic
20093466
COXM1_YEASTCMC1genetic
20093466
HAP4_YEASTHAP4genetic
20093466
FABG_YEASTOAR1genetic
20093466
UBI4P_YEASTUBI4genetic
20093466
COX12_YEASTCOX12genetic
20093466
MUB1_YEASTMUB1genetic
20093466
PKR1_YEASTPKR1genetic
20093466
COX7_YEASTCOX7genetic
20093466
EOS1_YEASTEOS1genetic
20093466
COX5A_YEASTCOX5Agenetic
20093466
COX10_YEASTCOX10genetic
20093466
TBP6_YEASTYTA6genetic
20093466
NTO1_YEASTNTO1genetic
20093466
SPEE_YEASTSPE3genetic
20093466
KAR3_YEASTKAR3genetic
20093466
RPN10_YEASTRPN10physical
24429290
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RPN13_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133; SER-135AND SER-140, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132 AND SER-135, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135 AND SER-140, ANDMASS SPECTROMETRY.

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