| UniProt ID | RPN12_YEAST | |
|---|---|---|
| UniProt AC | P32496 | |
| Protein Name | 26S proteasome regulatory subunit RPN12 | |
| Gene Name | RPN12 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 274 | |
| Subcellular Localization | ||
| Protein Description | Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase.. | |
| Protein Sequence | MPSLAELTKSLSIAFENGDYAACEKLLPPIKIELIKNNLLIPDLSIQNDIYLNDLMITKRILEVGALASIQTFNFDSFENYFNQLKPYYFSNNHKLSESDKKSKLISLYLLNLLSQNNTTKFHSELQYLDKHIKNLEDDSLLSYPIKLDRWLMEGSYQKAWDLLQSGSQNISEFDSFTDILKSAIRDEIAKNTELSYDFLPLSNIKALLFFNNEKETEKFALERNWPIVNSKVYFNNQSKEKADYEDEMMHEEDQKTNIIEKAMDYAISIENIV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MPSLAELTKS -----CCCHHHHHHH | 38.62 | 24909858 | |
| 8 | Phosphorylation | MPSLAELTKSLSIAF CCCHHHHHHHHHEEE | 15.30 | 24909858 | |
| 10 | Phosphorylation | SLAELTKSLSIAFEN CHHHHHHHHHEEECC | 23.32 | 24909858 | |
| 12 | Phosphorylation | AELTKSLSIAFENGD HHHHHHHHEEECCCC | 20.97 | 24909858 | |
| 31 | Acetylation | EKLLPPIKIELIKNN HHHCCCEEEEEEECC | 35.58 | 24489116 | |
| 131 | Acetylation | SELQYLDKHIKNLED HHHHHHHHHHHCCCC | 44.63 | 24489116 | |
| 147 | Acetylation | SLLSYPIKLDRWLME CCCCCCCCHHHHHHH | 39.57 | 24489116 | |
| 215 | Acetylation | LLFFNNEKETEKFAL EEEECCCHHHHHHHH | 72.55 | 24489116 | |
| 215 | Succinylation | LLFFNNEKETEKFAL EEEECCCHHHHHHHH | 72.55 | 23954790 | |
| 219 | Acetylation | NNEKETEKFALERNW CCCHHHHHHHHHCCC | 43.27 | 24489116 | |
| 257 | Phosphorylation | MHEEDQKTNIIEKAM CCHHHHHHCHHHHHH | 26.47 | 24961812 | |
| 269 | Phosphorylation | KAMDYAISIENIV-- HHHHHHHHHCCCC-- | 18.71 | 28152593 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RPN12_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RPN12_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RPN12_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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