| UniProt ID | CDC6_YEAST | |
|---|---|---|
| UniProt AC | P09119 | |
| Protein Name | Cell division control protein 6 | |
| Gene Name | CDC6 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 513 | |
| Subcellular Localization | Nucleus. Chromosome. | |
| Protein Description | Plays a crucial role in forming the pre-replicative complexes. Interacts with the origin recognition complex (ORC) and MCM2-7 helicase complex leading to the linking of those complexes and loading of the replicative helicase MCM2-7 onto the pre-replicative complexes. Required for the initiation of DNA replication and then actively participates in the suppression of nuclear division.. | |
| Protein Sequence | MSAIPITPTKRIRRNLFDDAPATPPRPLKRKKLQFTDVTPESSPEKLQFGSQSIFLRTKALLQKSSELVNLNSSDGALPARTAEYEQVMNFLAKAISEHRSDSLYITGPPGTGKTAQLDMIIRQKFQSLPLSLSTPRSKDVLRHTNPNLQNLSWFELPDGRLESVAVTSINCISLGEPSSIFQKIFDSFQDLNGPTLQIKNMQHLQKFLEPYHKKTTFVVVLDEMDRLLHANTSETQSVRTILELFLLAKLPTVSFVLIGMANSLDMKDRFLSRLNLDRGLLPQTIVFQPYTAEQMYEIVIQKMSSLPTIIFQPMAIKFAAKKCAGNTGDLRKLFDVLRGSIEIYELEKRFLLSPTRGSLNSAQVPLTPTTSPVKKSYPEPQGKIGLNYIAKVFSKFVNNNSTRTRIAKLNIQQKLILCTIIQSLKLNSDATIDESFDHYIKAITKTDTLAPLQRNEFLEICTILETCGLVSIKKTKCKGKTKRFVDKIDVDLDMREFYDEMTKISILKPFLH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MSAIPITPTKRIRR -CCCCCCCCCHHHHH | 21.39 | 10512865 | |
| 23 | Phosphorylation | LFDDAPATPPRPLKR CCCCCCCCCCCCCCC | 32.54 | 10512865 | |
| 39 | Phosphorylation | KLQFTDVTPESSPEK CCCCCCCCCCCCHHH | 24.93 | 10734126 | |
| 43 | Phosphorylation | TDVTPESSPEKLQFG CCCCCCCCHHHHCCC | 35.10 | 10512865 | |
| 128 | Phosphorylation | IIRQKFQSLPLSLST HHHHHHHCCCCCCCC | 34.78 | 19779198 | |
| 135 | Phosphorylation | SLPLSLSTPRSKDVL CCCCCCCCCCCHHHH | 28.19 | 10734126 | |
| 216 | Phosphorylation | LEPYHKKTTFVVVLD HHHHHCCCEEEEEEC | 30.21 | 26447709 | |
| 217 | Phosphorylation | EPYHKKTTFVVVLDE HHHHCCCEEEEEECC | 24.26 | 26447709 | |
| 354 | Phosphorylation | LEKRFLLSPTRGSLN CHHHHCCCCCCCCCC | 26.77 | 10734126 | |
| 368 | Phosphorylation | NSAQVPLTPTTSPVK CCCCCCCCCCCCCCC | 16.72 | 10734126 | |
| 370 | Phosphorylation | AQVPLTPTTSPVKKS CCCCCCCCCCCCCCC | 34.37 | 17130241 | |
| 371 | Phosphorylation | QVPLTPTTSPVKKSY CCCCCCCCCCCCCCC | 32.03 | 28889911 | |
| 372 | Phosphorylation | VPLTPTTSPVKKSYP CCCCCCCCCCCCCCC | 30.12 | 10512865 | |
| 395 | Phosphorylation | NYIAKVFSKFVNNNS HHHHHHHHHHHCCCC | 28.33 | 28889911 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDC6_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDC6_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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