IMDH4_YEAST - dbPTM
IMDH4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IMDH4_YEAST
UniProt AC P50094
Protein Name Inosine-5'-monophosphate dehydrogenase 4 {ECO:0000255|HAMAP-Rule:MF_03156}
Gene Name IMD4 {ECO:0000255|HAMAP-Rule:MF_03156}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 524
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth..
Protein Sequence MSAAPLDYKKALEHLKTYSSKDGLSVQELMDSTTRGGLTYNDFLVLPGLVNFPSSAVSLQTKLTKKITLNTPFVSSPMDTVTEADMAIYMALLGGIGFIHHNCTPKEQASMVKKVKMFENGFINSPIVISPTTTVGEVKVMKRKFGFSGFPVTEDGKCPGKLVGLVTSRDIQFLEDDSLVVSEVMTKNPVTGIKGITLKEGNEILKQTKKGKLLIVDDNGNLVSMLSRADLMKNQNYPLASKSATTKQLLCGAAIGTIEADKERLRLLVEAGLDVVILDSSQGNSVFQLNMIKWIKETFPDLEIIAGNVATREQAANLIAAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVCQFANQFGVPCMADGGVQNIGHITKALALGSSTVMMGGMLAGTTESPGEYFYKDGKRLKAYRGMGSIDAMQKTGNKGNASTSRYFSESDSVLVAQGVSGAVVDKGSIKKFIPYLYNGLQHSCQDIGCESLTSLKENVQNGEVRFEFRTASAQLEGGVHNLHSYEKRLYN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSAAPLDYK
------CCCCCCCHH		32.8922369663
8PhosphorylationMSAAPLDYKKALEHL
CCCCCCCHHHHHHHH		23.2822369663
9SuccinylationSAAPLDYKKALEHLK
CCCCCCHHHHHHHHH		31.1023954790
16AcetylationKKALEHLKTYSSKDG
HHHHHHHHHCCCCCC		47.5322865919
16UbiquitinationKKALEHLKTYSSKDG
HHHHHHHHHCCCCCC		47.5322817900
21SuccinylationHLKTYSSKDGLSVQE
HHHHCCCCCCCCHHH		50.2923954790
21AcetylationHLKTYSSKDGLSVQE
HHHHCCCCCCCCHHH		50.2924489116
21UbiquitinationHLKTYSSKDGLSVQE
HHHHCCCCCCCCHHH		50.2922817900
71PhosphorylationTKKITLNTPFVSSPM
CCEEECCCCCCCCCC		22.6330377154
76PhosphorylationLNTPFVSSPMDTVTE
CCCCCCCCCCCCCCH		20.9530377154
80PhosphorylationFVSSPMDTVTEADMA
CCCCCCCCCCHHHHH		24.0730377154
89PhosphorylationTEADMAIYMALLGGI
CHHHHHHHHHHHCCC		2.7030377154
104PhosphorylationGFIHHNCTPKEQASM
CCCCCCCCHHHHHHH		42.5930377154
113SuccinylationKEQASMVKKVKMFEN
HHHHHHHHHHHEECC		43.1123954790
125PhosphorylationFENGFINSPIVISPT
ECCCCCCCCEEECCC		15.9328889911
144AcetylationEVKVMKRKFGFSGFP
EEEEEECCCCCCCCC		44.3024489116
157AcetylationFPVTEDGKCPGKLVG
CCCCCCCCCCCEEEE		49.9624489116
161AcetylationEDGKCPGKLVGLVTS
CCCCCCCEEEEEEEC		25.7422865919
168PhosphorylationKLVGLVTSRDIQFLE
EEEEEEECCCCCCCC		22.0728889911
194AcetylationKNPVTGIKGITLKEG
CCCCCCCCCEEECCC		45.6822865919
199SuccinylationGIKGITLKEGNEILK
CCCCEEECCCCHHHH		55.7323954790
199AcetylationGIKGITLKEGNEILK
CCCCEEECCCCHHHH		55.7324489116
212AcetylationLKQTKKGKLLIVDDN
HHCCCCCCEEEECCC		49.3424489116
233AcetylationLSRADLMKNQNYPLA
HHHHHHHHCCCCCCC		63.7824489116
386PhosphorylationTKALALGSSTVMMGG
HHHHHHCCCEEEECC		24.5619823750
387PhosphorylationKALALGSSTVMMGGM
HHHHHCCCEEEECCC		24.1919823750
388PhosphorylationALALGSSTVMMGGML
HHHHCCCEEEECCCC		17.7019823750
398PhosphorylationMGGMLAGTTESPGEY
ECCCCCCCCCCCCCC		23.0619823750
399PhosphorylationGGMLAGTTESPGEYF
CCCCCCCCCCCCCCC		33.2819823750
401PhosphorylationMLAGTTESPGEYFYK
CCCCCCCCCCCCCCC		35.7919823750
405PhosphorylationTTESPGEYFYKDGKR
CCCCCCCCCCCCCCE		20.3719823750
407PhosphorylationESPGEYFYKDGKRLK
CCCCCCCCCCCCEEE		13.7819823750
408AcetylationSPGEYFYKDGKRLKA
CCCCCCCCCCCEEEE		50.5422865919
416PhosphorylationDGKRLKAYRGMGSID
CCCEEEECCCCCHHH		13.2027717283
421PhosphorylationKAYRGMGSIDAMQKT
EECCCCCHHHHHHHH		14.3822369663
428PhosphorylationSIDAMQKTGNKGNAS
HHHHHHHHCCCCCCC		29.1523749301
439PhosphorylationGNASTSRYFSESDSV
CCCCCCCCCCCCCEE		15.9527017623
441PhosphorylationASTSRYFSESDSVLV
CCCCCCCCCCCEEEE		27.5328889911
443PhosphorylationTSRYFSESDSVLVAQ
CCCCCCCCCEEEEEC		33.7130377154
445PhosphorylationRYFSESDSVLVAQGV
CCCCCCCEEEEECCC		26.9930377154
459UbiquitinationVSGAVVDKGSIKKFI
CCCEEECHHHHHHHH		42.8422817900
463UbiquitinationVVDKGSIKKFIPYLY
EECHHHHHHHHHHHH		43.2422817900
464UbiquitinationVDKGSIKKFIPYLYN
ECHHHHHHHHHHHHH		47.0222817900
503PhosphorylationEVRFEFRTASAQLEG
EEEEEEECCEEEECC		30.2224961812
505PhosphorylationRFEFRTASAQLEGGV
EEEEECCEEEECCCC		18.8828889911
517PhosphorylationGGVHNLHSYEKRLYN
CCCCCHHHHHHHHCC		37.8524961812
518PhosphorylationGVHNLHSYEKRLYN-
CCCCHHHHHHHHCC-		18.0930377154
520AcetylationHNLHSYEKRLYN---
CCHHHHHHHHCC---		39.2025381059
520UbiquitinationHNLHSYEKRLYN---
CCHHHHHHHHCC---		39.2023749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IMDH4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IMDH4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IMDH4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IPYR_YEASTIPP1physical
16554755
COX18_YEASTCOX18physical
16554755
IMDH2_YEASTIMD2physical
16554755
IF4E_YEASTCDC33physical
16429126
IMDH2_YEASTIMD2physical
16429126
RS8A_YEASTRPS8Aphysical
16429126
RS8B_YEASTRPS8Aphysical
16429126
G3P1_YEASTTDH1physical
16429126
G3P2_YEASTTDH2physical
16429126
XRN1_YEASTXRN1physical
16429126
IMDH3_YEASTIMD3physical
16429126
PABP_YEASTPAB1physical
16429126
RL7B_YEASTRPL7Bphysical
16429126
RS4A_YEASTRPS4Aphysical
16429126
RS4B_YEASTRPS4Aphysical
16429126
IMDH4_YEASTIMD4physical
18467557
RPB11_YEASTRPB11physical
18467557
PFD5_YEASTGIM5genetic
19061648
POM34_YEASTPOM34genetic
19061648
IMDH3_YEASTIMD3genetic
18408719
ELF1_YEASTELF1genetic
20093466
GMH1_YEASTGMH1genetic
20093466
CHIT_YEASTCTS1genetic
20093466
YL287_YEASTYLR287Cgenetic
20093466
NMD4_YEASTNMD4genetic
20093466
UBP15_YEASTUBP15genetic
20093466
HOL1_YEASTHOL1genetic
20093466
MOD5_YEASTMOD5genetic
20093466
FIT2_YEASTFIT2genetic
20093466
YP229_YEASTYPL229Wgenetic
20093466
THI6_YEASTTHI6genetic
20093466
RU2A_YEASTLEA1genetic
20093466
FUMH_YEASTFUM1genetic
21623372
KCS1_YEASTKCS1genetic
21623372
IMDH4_YEASTIMD4physical
22615397
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IMDH4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125 AND SER-168, ANDMASS SPECTROMETRY.

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