| UniProt ID | IMDH3_YEAST | |
|---|---|---|
| UniProt AC | P50095 | |
| Protein Name | Inosine-5'-monophosphate dehydrogenase 3 {ECO:0000255|HAMAP-Rule:MF_03156} | |
| Gene Name | IMD3 {ECO:0000255|HAMAP-Rule:MF_03156} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 523 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.. | |
| Protein Sequence | MAAVRDYKTALEFAKSLPRLDGLSVQELMDSKTRGGLTYNDFLVLPGLVDFPSSEVSLQTKLTRNITLNTPFVSSPMDTVTESEMAIFMALLGGIGFIHHNCTPEDQADMVRRVKNYENGFINNPIVISPTTTVGEAKSMKERFGFSGFPVTEDGKRNGKLMGIVTSRDIQFVEDNSLLVQDVMTKNPVTGAQGITLSEGNEILKKIKKGKLLIVDDNGNLVSMLSRTDLMKNQNYPLASKSATTKQLLCGAAIGTIDADKERLRLLVEAGLDVVILDSSQGNSIFQLNMIKWIKETFPDLEIIAGNVATREQAANLIAAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVCEFANQFGIPCMADGGVQNIGHITKALALGSSTVMMGGMLAGTTESPGEYFYQDGKRLKAYRGMGSIDAMQKTGTKGNASTSRYFSESDSVLVAQGVSGAVVDKGSIKKFIPYLYNGLQHSCQDIGYKSLTLLKENVQSGKVRFEFRTASAQLEGGVHNLHSYEKRLHN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Succinylation | MAAVRDYKTALEFAK CCCCCCHHHHHHHHH | 31.45 | 23954790 | |
| 8 | Acetylation | MAAVRDYKTALEFAK CCCCCCHHHHHHHHH | 31.45 | 24489116 | |
| 15 | Acetylation | KTALEFAKSLPRLDG HHHHHHHHCCCCCCC | 58.82 | 24489116 | |
| 15 | Ubiquitination | KTALEFAKSLPRLDG HHHHHHHHCCCCCCC | 58.82 | 24961812 | |
| 16 | Phosphorylation | TALEFAKSLPRLDGL HHHHHHHCCCCCCCC | 39.93 | 25521595 | |
| 24 | Phosphorylation | LPRLDGLSVQELMDS CCCCCCCCHHHHHCC | 27.55 | 21440633 | |
| 32 | Acetylation | VQELMDSKTRGGLTY HHHHHCCCCCCCCCH | 37.67 | 24489116 | |
| 32 | Ubiquitination | VQELMDSKTRGGLTY HHHHHCCCCCCCCCH | 37.67 | 23749301 | |
| 129 | Phosphorylation | INNPIVISPTTTVGE CCCCEEECCCCCCCC | 12.80 | 25752575 | |
| 156 | Acetylation | FPVTEDGKRNGKLMG CEECCCCCCCCEEEE | 55.82 | 24489116 | |
| 156 | Ubiquitination | FPVTEDGKRNGKLMG CEECCCCCCCCEEEE | 55.82 | 23749301 | |
| 160 | Acetylation | EDGKRNGKLMGIVTS CCCCCCCEEEEEEEC | 38.56 | 24489116 | |
| 167 | Phosphorylation | KLMGIVTSRDIQFVE EEEEEEECCCCEEEC | 19.64 | 30377154 | |
| 198 | Phosphorylation | GAQGITLSEGNEILK CCCCEECCCCHHHHH | 34.50 | 28152593 | |
| 205 | Ubiquitination | SEGNEILKKIKKGKL CCCHHHHHHHHCCCE | 59.10 | 23749301 | |
| 241 | 2-Hydroxyisobutyrylation | QNYPLASKSATTKQL CCCCCCCCCCCHHHH | 38.20 | - | |
| 261 | Acetylation | IGTIDADKERLRLLV EECCCCCHHHHHHHH | 46.59 | 24489116 | |
| 385 | Phosphorylation | TKALALGSSTVMMGG HHHHHHCCCEEEECC | 24.56 | 19823750 | |
| 386 | Phosphorylation | KALALGSSTVMMGGM HHHHHCCCEEEECCC | 24.19 | 19823750 | |
| 397 | Phosphorylation | MGGMLAGTTESPGEY ECCCCCCCCCCCCCC | 23.06 | 28889911 | |
| 415 | Phosphorylation | DGKRLKAYRGMGSID CCCCCHHHCCCCHHH | 13.20 | 27017623 | |
| 420 | Phosphorylation | KAYRGMGSIDAMQKT HHHCCCCHHHHHHHH | 14.38 | 22369663 | |
| 427 | Phosphorylation | SIDAMQKTGTKGNAS HHHHHHHHCCCCCCC | 32.94 | 23749301 | |
| 438 | Phosphorylation | GNASTSRYFSESDSV CCCCCCCEECCCCEE | 15.95 | 27017623 | |
| 440 | Phosphorylation | ASTSRYFSESDSVLV CCCCCEECCCCEEEE | 27.53 | 28889911 | |
| 442 | Phosphorylation | TSRYFSESDSVLVAQ CCCEECCCCEEEEEC | 33.71 | 30377154 | |
| 444 | Phosphorylation | RYFSESDSVLVAQGV CEECCCCEEEEECCC | 26.99 | 30377154 | |
| 458 | Ubiquitination | VSGAVVDKGSIKKFI CCCEEECHHHHHHHH | 42.84 | 22817900 | |
| 462 | Ubiquitination | VVDKGSIKKFIPYLY EECHHHHHHHHHHHH | 43.24 | 22817900 | |
| 463 | Ubiquitination | VDKGSIKKFIPYLYN ECHHHHHHHHHHHHH | 47.02 | 23749301 | |
| 485 | Phosphorylation | DIGYKSLTLLKENVQ HHCHHHHEEHHHHHH | 36.82 | 22369663 | |
| 495 | Ubiquitination | KENVQSGKVRFEFRT HHHHHCCCEEEEEEE | 35.17 | 23749301 | |
| 502 | Phosphorylation | KVRFEFRTASAQLEG CEEEEEEECEEEECC | 30.22 | 24961812 | |
| 504 | Phosphorylation | RFEFRTASAQLEGGV EEEEEECEEEECCCC | 18.88 | 25704821 | |
| 516 | Phosphorylation | GGVHNLHSYEKRLHN CCCCCHHCHHHHHCC | 37.85 | 28889911 | |
| 517 | Phosphorylation | GVHNLHSYEKRLHN- CCCCHHCHHHHHCC- | 18.09 | 30377154 | |
| 519 | Ubiquitination | HNLHSYEKRLHN--- CCHHCHHHHHCC--- | 52.61 | 23749301 | |
| 519 | 2-Hydroxyisobutyrylation | HNLHSYEKRLHN--- CCHHCHHHHHCC--- | 52.61 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IMDH3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IMDH3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IMDH3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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