DHE2_YEAST - dbPTM
DHE2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DHE2_YEAST
UniProt AC P33327
Protein Name NAD-specific glutamate dehydrogenase
Gene Name GDH2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1092
Subcellular Localization
Protein Description NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate..
Protein Sequence MLFDNKNRGALNSLNTPDIASLSISSMSDYHVFDFPGKDLQREEVIDLLDQQGFIPDDLIEQEVDWFYNSLGIDDLFFSRESPQLISNIIHSLYASKLDFFAKSKFNGIQPRLFSIKNKIITNDNHAIFMESNTGVSISDSQQKNFKFASDAVGNDTLEHGKDTIKKNRIEMDDSCPPYELDSEIDDLFLDNKSQKNCRLVSFWAPESELKLTFVYESVYPNDDPAGVDISSQDLLKGDIESISDKTMYKVSSNENKKLYGLLLKLVKEREGPVIKTTRSVENKDEIRLLVAYKRFTTKRYYSALNSLFHYYKLKPSKFYLESFNVKDDDIIIFSVYLNENQQLEDVLLHDVEAALKQVEREASLLYAIPNNSFHEVYQRRQFSPKEAIYAHIGAIFINHFVNRLGSDYQNLLSQITIKRNDTTLLEIVENLKRKLRNETLTQQTIINIMSKHYTIISKLYKNFAQIHYYHNSTKDMEKTLSFQRLEKVEPFKNDQEFEAYLNKFIPNDSPDLLILKTLNIFNKSILKTNFFITRKVAISFRLDPSLVMTKFEYPETPYGIFFVVGNTFKGFHIRFRDIARGGIRIVCSRNQDIYDLNSKNVIDENYQLASTQQRKNKDIPEGGSKGVILLNPGLVEHDQTFVAFSQYVDAMIDILINDPLKENYVNLLPKEEILFFGPDEGTAGFVDWATNHARVRNCPWWKSFLTGKSPSLGGIPHDEYGMTSLGVRAYVNKIYETLNLTNSTVYKFQTGGPDGDLGSNEILLSSPNECYLAILDGSGVLCDPKGLDKDELCRLAHERKMISDFDTSKLSNNGFFVSVDAMDIMLPNGTIVANGTTFRNTFHTQIFKFVDHVDIFVPCGGRPNSITLNNLHYFVDEKTGKCKIPYIVEGANLFITQPAKNALEEHGCILFKDASANKGGVTSSSMEVLASLALNDNDFVHKFIGDVSGERSALYKSYVVEVQSRIQKNAELEFGQLWNLNQLNGTHISEISNQLSFTINKLNDDLVASQELWLNDLKLRNYLLLDKIIPKILIDVAGPQSVLENIPESYLKVLLSSYLSSTFVYQNGIDVNIGKFLEFIGGLKREAEASA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationKNRGALNSLNTPDIA
CCCCCHHCCCCCCCE		24.6822369663
16PhosphorylationGALNSLNTPDIASLS
CCHHCCCCCCCEEEE		27.8622369663
21PhosphorylationLNTPDIASLSISSMS
CCCCCCEEEEEHHCC		24.0022369663
23PhosphorylationTPDIASLSISSMSDY
CCCCEEEEEHHCCCC		20.2322369663
25PhosphorylationDIASLSISSMSDYHV
CCEEEEEHHCCCCEE		19.3322369663
26PhosphorylationIASLSISSMSDYHVF
CEEEEEHHCCCCEEE		22.1922369663
28PhosphorylationSLSISSMSDYHVFDF
EEEEHHCCCCEEECC		36.6422369663
30PhosphorylationSISSMSDYHVFDFPG
EEHHCCCCEEECCCC		7.8025371407
157PhosphorylationSDAVGNDTLEHGKDT
CCCCCCCCHHCCCCC		37.7425371407
162AcetylationNDTLEHGKDTIKKNR
CCCHHCCCCCHHHCC		54.3125381059
242PhosphorylationLLKGDIESISDKTMY
HHCCCHHHCCCCEEE		27.9427214570
276AcetylationEREGPVIKTTRSVEN
HCCCCEEEEECCCCC		44.0425381059
480PhosphorylationSTKDMEKTLSFQRLE
CCCCHHHHHHHHHHH		17.8322369663
482PhosphorylationKDMEKTLSFQRLEKV
CCHHHHHHHHHHHCC		25.2722369663
546PhosphorylationISFRLDPSLVMTKFE
EEEECCHHHEEEEEE		33.0127017623
710PhosphorylationKSFLTGKSPSLGGIP
HHHHHCCCCCCCCCC		22.5227017623
712PhosphorylationFLTGKSPSLGGIPHD
HHHCCCCCCCCCCCC		46.8927017623
725PhosphorylationHDEYGMTSLGVRAYV
CCCCCCCCHHHHHHH		17.7727017623
736PhosphorylationRAYVNKIYETLNLTN
HHHHHHHHHHHCCCC		12.4127017623
742PhosphorylationIYETLNLTNSTVYKF
HHHHHCCCCCEEEEE		26.5027017623
747PhosphorylationNLTNSTVYKFQTGGP
CCCCCEEEEEECCCC		13.2327017623
1023PhosphorylationNDLKLRNYLLLDKII
HHHHHHHHHHHHCHH		7.7228889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DHE2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DHE2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DHE2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DNM1_YEASTDNM1physical
18467557
AATC_YEASTAAT2physical
18467557
PEX11_YEASTPEX11physical
18467557
BDH2_YEASTBDH2genetic
20093466
HPH2_YEASTFRT2genetic
20093466
DEP1_YEASTDEP1genetic
20093466
RS8A_YEASTRPS8Agenetic
20093466
RS8B_YEASTRPS8Agenetic
20093466
FUI1_YEASTFUI1genetic
20093466
SHE1_YEASTSHE1genetic
20093466
FLR1_YEASTFLR1genetic
20093466
YBM6_YEASTYBR016Wgenetic
20093466
ADH5_YEASTADH5genetic
20093466
PEX32_YEASTPEX32genetic
20093466
PYC2_YEASTPYC2genetic
20093466
BUD31_YEASTBUD31genetic
20093466
VMS1_YEASTVMS1genetic
20093466
CP56_YEASTDIT2genetic
20093466
RPOM_YEASTRPO41genetic
20093466
LSB3_YEASTLSB3genetic
20093466
HAP2_YEASTHAP2genetic
20093466
YGP9_YEASTYGL159Wgenetic
20093466
RPN14_YEASTRPN14genetic
20093466
RS25A_YEASTRPS25Agenetic
20093466
QCR9_YEASTQCR9genetic
20093466
SHU1_YEASTSHU1genetic
20093466
FYV4_YEASTFYV4genetic
20093466
POG1_YEASTPOG1genetic
20093466
COPE_YEASTSEC28genetic
20093466
VHR1_YEASTVHR1genetic
20093466
MNN11_YEASTMNN11genetic
20093466
YJQ3_YEASTYJL163Cgenetic
20093466
PIR5_YEASTYJL160Cgenetic
20093466
MTC1_YEASTMTC1genetic
20093466
MDV1_YEASTMDV1genetic
20093466
LPLA_YEASTAIM22genetic
20093466
YJ24_YEASTKCH1genetic
20093466
TCD2_YEASTTCD2genetic
20093466
PUT3_YEASTPUT3genetic
20093466
GMH1_YEASTGMH1genetic
20093466
RT109_YEASTRTT109genetic
20093466
COX12_YEASTCOX12genetic
20093466
SWI6_YEASTSWI6genetic
20093466
IRC20_YEASTIRC20genetic
20093466
YL257_YEASTYLR257Wgenetic
20093466
PIG1_YEASTPIG1genetic
20093466
YL422_YEASTYLR422Wgenetic
20093466
GCSP_YEASTGCV2genetic
20093466
PFKA2_YEASTPFK2genetic
20093466
RS7B_YEASTRPS7Bgenetic
20093466
NST1_YEASTNST1genetic
20093466
SWS2_YEASTSWS2genetic
20093466
ALG12_YEASTALG12genetic
20093466
SYC1_YEASTSYC1genetic
20093466
ISW2_YEASTISW2genetic
20093466
DBP1_YEASTDBP1genetic
20093466
GSHR_YEASTGLR1genetic
20093466
TKT1_YEASTTKL1genetic
20093466
IDH2_YEASTIDH2genetic
21623372
ERG2_YEASTERG2genetic
21623372
QCR9_YEASTQCR9genetic
21623372
ECI1_YEASTECI1genetic
21623372
QCR7_YEASTQCR7genetic
21623372
ETR1_YEASTETR1genetic
21623372
PRX1_YEASTPRX1genetic
21623372
FABD_YEASTMCT1genetic
21623372
FCY2_YEASTFCY2genetic
21623372
METX_YEASTYML082Wgenetic
21623372
GGPPS_YEASTBTS1genetic
21623372
SPSY_YEASTSPE4genetic
21623372
ADK_YEASTADO1genetic
21623372
URH1_YEASTURH1genetic
21623372
SCS7_YEASTSCS7genetic
21623372
PFF1_YEASTPFF1genetic
27708008
ASK10_YEASTASK10genetic
27708008
QCR9_YEASTQCR9genetic
27708008
SDS3_YEASTSDS3genetic
27708008
PSH1_YEASTPSH1genetic
27708008
FUI1_YEASTFUI1genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
DSF2_YEASTDSF2genetic
27708008
SCO2_YEASTSCO2genetic
27708008
NPL4_YEASTNPL4genetic
27708008
RIM1_YEASTRIM1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
CP56_YEASTDIT2genetic
27708008
DIT1_YEASTDIT1genetic
27708008
PT122_YEASTPET122genetic
27708008
RPN14_YEASTRPN14genetic
27708008
MRM2_YEASTMRM2genetic
27708008
YGP9_YEASTYGL159Wgenetic
27708008
XRN1_YEASTXRN1genetic
27708008
6PGD2_YEASTGND2genetic
27708008
SHU1_YEASTSHU1genetic
27708008
COX23_YEASTCOX23genetic
27708008
LPLA_YEASTAIM22genetic
27708008
MDV1_YEASTMDV1genetic
27708008
MTC1_YEASTMTC1genetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
YJQ3_YEASTYJL163Cgenetic
27708008
MNN11_YEASTMNN11genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
PUT3_YEASTPUT3genetic
27708008
TCD2_YEASTTCD2genetic
27708008
GMH1_YEASTGMH1genetic
27708008
RT109_YEASTRTT109genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
YL042_YEASTYLR042Cgenetic
27708008
SWI6_YEASTSWI6genetic
27708008
IRC20_YEASTIRC20genetic
27708008
CTK3_YEASTCTK3genetic
27708008
MAC1_YEASTMAC1genetic
27708008
GCSP_YEASTGCV2genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
SIW14_YEASTSIW14genetic
27708008
SWS2_YEASTSWS2genetic
27708008
RS7B_YEASTRPS7Bgenetic
27708008
ALG12_YEASTALG12genetic
27708008
MSH2_YEASTMSH2genetic
27708008
CRC1_YEASTCRC1genetic
27708008
VAM3_YEASTVAM3genetic
27708008
SSP2_YEASTSSP2genetic
27708008
ISW2_YEASTISW2genetic
27708008
HAP5_YEASTHAP5genetic
27708008
DBP1_YEASTDBP1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DHE2_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; SER-28 AND SER-242,AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-482, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory