ALG12_YEAST - dbPTM
ALG12_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ALG12_YEAST
UniProt AC P53730
Protein Name Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
Gene Name ALG12
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 551
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation..
Protein Sequence MRWSVLDTVLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVFDISQYDHLKFPGVVPRTFVGAVIIAMLSRPYLYLSSLIQTSRPTSIDVQLVVRGIVGLTNGLSFIYLKNCLQDMFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVALGWVLLGRYNAAIFLSALVAIVFRLEVSALSAGIALFSVIFKKISLFDAIKFGIFGLGLGSAISITVDSYFWQEWCLPEVDGFLFNVVAGYASKWGVEPVTAYFTHYLRMMFMPPTVLLLNYFGYKLAPAKLKIVSLASLFHIIVLSFQPHKEWRFIIYAVPSIMLLGATGAAHLWENMKVKKITNVLCLAILPLSIMTSFFISMAFLYISRMNYPGGEALTSFNDMIVEKNITNATVHISIPPCMTGVTLFGELNYGVYGINYDKTENTTLLQEMWPSFDFLITHEPTASQLPFENKTTNHWELVNTTKMFTGFDPTYIKNFVFQERVNVLSLLKQIIFDKTPTVFLKELTANSIVKSDVFFTYKRIKQDEKTD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
292PhosphorylationRMMFMPPTVLLLNYF
HHHHCCCEEHHHHHC		20.2227017623
298PhosphorylationPTVLLLNYFGYKLAP
CEEHHHHHCCCCCCC		9.8027017623
542SuccinylationSDVFFTYKRIKQDEK
CCEEEEEEECCCCCC		44.5923954790
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ALG12_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ALG12_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ALG12_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
OST3_YEASTOST3genetic
16269340
OST5_YEASTOST5genetic
16269340
HAC1_YEASTHAC1genetic
16269340
IRE1_YEASTIRE1genetic
16269340
OSTB_YEASTWBP1genetic
16269340
ATC1_YEASTPMR1genetic
16269340
GAS1_YEASTGAS1genetic
16269340
DPM1_YEASTDPM1genetic
16269340
LST8_YEASTLST8genetic
16269340
ASI3_YEASTASI3genetic
16269340
SCS7_YEASTSCS7genetic
16269340
ATC6_YEASTSPF1genetic
16269340
SEC66_YEASTSEC66genetic
16269340
GPI8_YEASTGPI8genetic
16269340
ALG9_YEASTALG9genetic
16269340
GUP1_YEASTGUP1genetic
16269340
RUD3_YEASTRUD3genetic
16269340
OST6_YEASTOST6genetic
16269340
ILM1_YEASTILM1genetic
16269340
LHS1_YEASTLHS1genetic
16269340
GST1_YEASTGTT1physical
18719252
MGA2_YEASTMGA2physical
18719252
SIN3_YEASTSIN3genetic
19547744
ALG3_YEASTALG3genetic
19325107
ALG5_YEASTALG5genetic
19325107
ALG6_YEASTALG6genetic
19325107
ALG8_YEASTALG8genetic
19325107
ALG9_YEASTALG9genetic
19325107
GGPPS_YEASTBTS1genetic
19325107
ALG10_YEASTDIE2genetic
19325107
ERD1_YEASTERD1genetic
19325107
ERG2_YEASTERG2genetic
19325107
GCR2_YEASTGCR2genetic
19325107
GET2_YEASTGET2genetic
19325107
ILM1_YEASTILM1genetic
19325107
PLMT_YEASTOPI3genetic
19325107
OST5_YEASTOST5genetic
19325107
ATC1_YEASTPMR1genetic
19325107
SMI1_YEASTSMI1genetic
19325107
SPT4_YEASTSPT4genetic
19325107
VPS1_YEASTVPS1genetic
19325107
ZAP1_YEASTZAP1genetic
19325107
ERP1_YEASTERP1genetic
19325107
SUM1_YEASTSUM1genetic
19325107
SWC5_YEASTSWC5genetic
19325107
VPS71_YEASTVPS71genetic
19325107
SIR2_YEASTSIR2genetic
21902802
BEM1_YEASTBEM1genetic
21987634
OSTB_YEASTWBP1genetic
21987634
ISC1_YEASTISC1genetic
21987634
GET2_YEASTGET2genetic
21987634
HAC1_YEASTHAC1genetic
21987634
GET1_YEASTGET1genetic
21987634
ATC1_YEASTPMR1genetic
21987634
OST5_YEASTOST5genetic
21987634
IRE1_YEASTIRE1genetic
21987634
ILM1_YEASTILM1genetic
21987634
CCW12_YEASTCCW12genetic
21987634
IPYR2_YEASTPPA2genetic
21987634
GAS1_YEASTGAS1genetic
21987634
VDAC1_YEASTPOR1genetic
21987634
INO4_YEASTINO4genetic
21987634
OST3_YEASTOST3genetic
21987634
AIM44_YEASTAIM44genetic
21987634
DPM1_YEASTDPM1genetic
21987634
HAC1_YEASTHAC1genetic
23891562
IRE1_YEASTIRE1genetic
23891562
STT3_YEASTSTT3genetic
23891562
OST5_YEASTOST5genetic
23891562
OSTB_YEASTWBP1genetic
23891562
OSTD_YEASTSWP1genetic
23891562
OST1_YEASTOST1genetic
23891562
OST3_YEASTOST3genetic
23891562
STE24_YEASTSTE24genetic
23891562
GET2_YEASTGET2genetic
23891562
GLO3_YEASTGLO3genetic
23891562
RUD3_YEASTRUD3genetic
23891562
CCW12_YEASTCCW12genetic
23891562
SRO7_YEASTSRO7genetic
23891562
CSG2_YEASTCSG2genetic
23891562
SEC9_YEASTSEC9genetic
23891562
CDC1_YEASTCDC1genetic
27708008
INO4_YEASTINO4genetic
27708008
RSC6_YEASTRSC6genetic
27708008
STT3_YEASTSTT3genetic
27708008
DPM1_YEASTDPM1genetic
27708008
AGP1_YEASTAGP1genetic
27708008
OST4_YEASTOST4genetic
27708008
MNN10_YEASTMNN10genetic
27708008
HAC1_YEASTHAC1genetic
27708008
KEX1_YEASTKEX1genetic
27708008
OST5_YEASTOST5genetic
27708008
MED20_YEASTSRB2genetic
27708008
IRE1_YEASTIRE1genetic
27708008
YJ24_YEASTKCH1genetic
27708008
ERG3_YEASTERG3genetic
27708008
SST2_YEASTSST2genetic
27708008
OST6_YEASTOST6genetic
27708008
SKY1_YEASTSKY1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
OST3_YEASTOST3genetic
27708008
IRE1_YEASTIRE1genetic
24391512
HAC1_YEASTHAC1genetic
24391512
KASH5_HUMANCCDC155physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ALG12_YEAST

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Related Literatures of Post-Translational Modification

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