| UniProt ID | GPI8_YEAST | |
|---|---|---|
| UniProt AC | P49018 | |
| Protein Name | GPI-anchor transamidase | |
| Gene Name | GPI8 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 411 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type I membrane protein. |
|
| Protein Description | Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.. | |
| Protein Sequence | MRIAMHLPLLLLYIFLLPLSGANNTDAAHEVIATNTNNWAVLVSTSRFWFNYRHMANVLSMYRTVKRLGIPDSQIILMLSDDVACNSRNLFPGSVFNNKDHAIDLYGDSVEVDYRGYEVTVENFIRLLTDRWTEDHPKSKRLLTDENSNIFIYMTGHGGDDFLKFQDAEEIASEDIADAFQQMYEKKRYNEIFFMIDTCQANTMYSKFYSPNILAVGSSEMDESSYSHHSDVEIGVAVIDRFTYYCLDFLEQIDKNSTLTLQDLFDSFTFEKIHSHVGVRTDLFDRNPSEVLITDFFANVQNVIPDDSKPLSVSHYHHYKDHIDTAQYELNNNVLDLALETYRKNNQSSKIEKKIKDIKSTSVLDVDIDSNECFFTSFKQSATIILALIVTILWFMLRGNTAKATYDLYTN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 60 | Phosphorylation | RHMANVLSMYRTVKR HHHHHHHHHHHHHHH | 14.97 | 27017623 | |
| 62 | Phosphorylation | MANVLSMYRTVKRLG HHHHHHHHHHHHHHC | 10.35 | 27017623 | |
| 256 | N-linked_Glycosylation | FLEQIDKNSTLTLQD HHHHHCCCCCEEHHH | 36.16 | - | |
| 257 | Phosphorylation | LEQIDKNSTLTLQDL HHHHCCCCCEEHHHH | 30.45 | 22369663 | |
| 258 | Phosphorylation | EQIDKNSTLTLQDLF HHHCCCCCEEHHHHH | 32.91 | 22369663 | |
| 260 | Phosphorylation | IDKNSTLTLQDLFDS HCCCCCEEHHHHHHH | 23.59 | 22369663 | |
| 267 | Phosphorylation | TLQDLFDSFTFEKIH EHHHHHHHCCHHHHH | 20.89 | 22369663 | |
| 269 | Phosphorylation | QDLFDSFTFEKIHSH HHHHHHCCHHHHHHH | 34.53 | 22369663 | |
| 346 | N-linked_Glycosylation | LETYRKNNQSSKIEK HHHHHHHCCCHHHHH | 46.26 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GPI8_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GPI8_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GPI8_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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