| UniProt ID | FYV8_YEAST | |
|---|---|---|
| UniProt AC | P46949 | |
| Protein Name | Protein FYV8 | |
| Gene Name | FYV8 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 817 | |
| Subcellular Localization | ||
| Protein Description | Required for survival upon exposure to K1 killer toxin. Involved in the resistance to unfolded protein response (UPR)-inducing agents.. | |
| Protein Sequence | MSTEQVGRKKSYRWVSASQASYDGAGWDSSDEYDYSSEDGTKGSEIHKQKISNLPSLPKLNYTDVNGEHDENTGENKDSNDNNVSKSDISPSDKEVGYLSDGVPKLMASRESVELQAKKSSEHSKSDYLSSTASLKSPSENKKSPHTNRAVNEDLDNLIEQISREMTPEIRQTSDFRRDSDSCDEIQNEAPLGEAVPSSSSPVEEDEKSHSLGVSMDTNEADTTFNTPTRNGNEHLSSDGDVSEQKDDEFKVSERGYLADILPAEKEENLQQEDDGEVESSGALEKKEKSEEKTSIRNRNSTSSGQDKVAKPKPVANETKTSDNGYRNSFFNDYQHSSDSEEDDNNEGNSGSSDDDNRSSVSDKHADINRQSKQLDTTDDDALSYTESIKYSTNETEEEDNEDNESIEDKNEDNESIEDENEDTDSYKFSNREKGSILLTSDEEEEEKGMSSDSDEGSLKAPKSGYFSKMIGNDDKGDSALQPNQIDTIENTNLSNSGSELENSDGSDEEDHINEDKVLEESSVKDSTDVDSWKPDSEALRSGFVQDTANKKAPPGYVIDSNGKLVDLTPASMKPRVVSTYSEMESTWDAFPSKGEDDDLETIRDTKTIYDNNTIYNVPGLIGNQSNLPPLPMDAQEQLNAGNDNSTTDNDNSNNTANDLAARSASFKSENRTVSQGEMTSVHEPSTEEMAKLGQQNNLPKLDMNKLLNSKTSHAGKIEQLRNYKRELDEYDTGIQTWINYTLKSSSNKDKDFIAEEYKQHSHVREAYANADDLSKKHTVINTVASVNQNVTHLRRKVFQHSMKPKDLFASIGKKKL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSTEQVGRK ------CCHHHCCCC | 40.42 | 27717283 | |
| 3 | Phosphorylation | -----MSTEQVGRKK -----CCHHHCCCCC | 29.19 | 27717283 | |
| 41 | Phosphorylation | DYSSEDGTKGSEIHK CCCCCCCCCCCHHHH | 44.55 | 27017623 | |
| 56 | Phosphorylation | QKISNLPSLPKLNYT HHHHCCCCCCCCCCC | 61.54 | 22369663 | |
| 63 | Phosphorylation | SLPKLNYTDVNGEHD CCCCCCCCCCCCCCC | 32.19 | 19795423 | |
| 73 | Phosphorylation | NGEHDENTGENKDSN CCCCCCCCCCCCCCC | 43.77 | 21440633 | |
| 79 | Phosphorylation | NTGENKDSNDNNVSK CCCCCCCCCCCCCCH | 47.93 | 20377248 | |
| 85 | Phosphorylation | DSNDNNVSKSDISPS CCCCCCCCHHHCCCC | 28.68 | 22369663 | |
| 87 | Phosphorylation | NDNNVSKSDISPSDK CCCCCCHHHCCCCHH | 32.44 | 22369663 | |
| 90 | Phosphorylation | NVSKSDISPSDKEVG CCCHHHCCCCHHHHC | 24.28 | 22369663 | |
| 92 | Phosphorylation | SKSDISPSDKEVGYL CHHHCCCCHHHHCCC | 55.30 | 22369663 | |
| 98 | Phosphorylation | PSDKEVGYLSDGVPK CCHHHHCCCCCCHHH | 14.28 | 22890988 | |
| 100 | Phosphorylation | DKEVGYLSDGVPKLM HHHHCCCCCCHHHHH | 24.68 | 22369663 | |
| 109 | Phosphorylation | GVPKLMASRESVELQ CHHHHHHCHHHHHHH | 23.71 | 22369663 | |
| 112 | Phosphorylation | KLMASRESVELQAKK HHHHCHHHHHHHHHC | 21.56 | 22369663 | |
| 121 | Phosphorylation | ELQAKKSSEHSKSDY HHHHHCCCCCCCHHH | 48.48 | 19779198 | |
| 125 | Acetylation | KKSSEHSKSDYLSST HCCCCCCCHHHHHCC | 49.61 | 24489116 | |
| 126 | Phosphorylation | KSSEHSKSDYLSSTA CCCCCCCHHHHHCCC | 34.21 | 22369663 | |
| 128 | Phosphorylation | SEHSKSDYLSSTASL CCCCCHHHHHCCCCC | 18.64 | 22369663 | |
| 130 | Phosphorylation | HSKSDYLSSTASLKS CCCHHHHHCCCCCCC | 21.29 | 22369663 | |
| 131 | Phosphorylation | SKSDYLSSTASLKSP CCHHHHHCCCCCCCC | 25.95 | 22369663 | |
| 132 | Phosphorylation | KSDYLSSTASLKSPS CHHHHHCCCCCCCCC | 19.52 | 22369663 | |
| 134 | Phosphorylation | DYLSSTASLKSPSEN HHHHCCCCCCCCCCC | 36.10 | 22369663 | |
| 137 | Phosphorylation | SSTASLKSPSENKKS HCCCCCCCCCCCCCC | 38.66 | 22369663 | |
| 139 | Phosphorylation | TASLKSPSENKKSPH CCCCCCCCCCCCCCC | 61.97 | 21551504 | |
| 163 | Phosphorylation | DNLIEQISREMTPEI HHHHHHHHHHCCHHH | 23.14 | 22369663 | |
| 167 | Phosphorylation | EQISREMTPEIRQTS HHHHHHCCHHHHHCC | 17.02 | 22369663 | |
| 180 | Phosphorylation | TSDFRRDSDSCDEIQ CCCCCCCCCCHHHHH | 29.61 | 19795423 | |
| 182 | Phosphorylation | DFRRDSDSCDEIQNE CCCCCCCCHHHHHHC | 27.67 | 28152593 | |
| 198 | Phosphorylation | PLGEAVPSSSSPVEE CCCCCCCCCCCCCCC | 35.93 | 27017623 | |
| 201 | Phosphorylation | EAVPSSSSPVEEDEK CCCCCCCCCCCCCHH | 34.61 | 27017623 | |
| 209 | Phosphorylation | PVEEDEKSHSLGVSM CCCCCHHHHCCCCCC | 19.09 | 22369663 | |
| 211 | Phosphorylation | EEDEKSHSLGVSMDT CCCHHHHCCCCCCCC | 33.63 | 22369663 | |
| 215 | Phosphorylation | KSHSLGVSMDTNEAD HHHCCCCCCCCCCCC | 14.78 | 22369663 | |
| 218 | Phosphorylation | SLGVSMDTNEADTTF CCCCCCCCCCCCCCC | 26.73 | 28132839 | |
| 223 | Phosphorylation | MDTNEADTTFNTPTR CCCCCCCCCCCCCCC | 40.09 | 22369663 | |
| 224 | Phosphorylation | DTNEADTTFNTPTRN CCCCCCCCCCCCCCC | 18.55 | 22369663 | |
| 227 | Phosphorylation | EADTTFNTPTRNGNE CCCCCCCCCCCCCCC | 23.11 | 22369663 | |
| 229 | Phosphorylation | DTTFNTPTRNGNEHL CCCCCCCCCCCCCCC | 34.43 | 22369663 | |
| 237 | Phosphorylation | RNGNEHLSSDGDVSE CCCCCCCCCCCCCCC | 28.43 | 22369663 | |
| 238 | Phosphorylation | NGNEHLSSDGDVSEQ CCCCCCCCCCCCCCC | 52.55 | 22369663 | |
| 243 | Phosphorylation | LSSDGDVSEQKDDEF CCCCCCCCCCCCCCC | 38.76 | 22369663 | |
| 253 | Phosphorylation | KDDEFKVSERGYLAD CCCCCEECCCHHHHH | 23.36 | 19823750 | |
| 257 | Phosphorylation | FKVSERGYLADILPA CEECCCHHHHHCCCH | 12.63 | 19823750 | |
| 280 | Phosphorylation | EDDGEVESSGALEKK CCCCCCCCHHHHCHH | 38.97 | 22369663 | |
| 281 | Phosphorylation | DDGEVESSGALEKKE CCCCCCCHHHHCHHH | 17.99 | 22369663 | |
| 290 | Phosphorylation | ALEKKEKSEEKTSIR HHCHHHHCCCHHCCC | 52.67 | 28889911 | |
| 294 | Phosphorylation | KEKSEEKTSIRNRNS HHHCCCHHCCCCCCC | 32.44 | 19823750 | |
| 295 | Phosphorylation | EKSEEKTSIRNRNST HHCCCHHCCCCCCCC | 30.53 | 19823750 | |
| 301 | Phosphorylation | TSIRNRNSTSSGQDK HCCCCCCCCCCCCCC | 26.82 | 19823750 | |
| 302 | Phosphorylation | SIRNRNSTSSGQDKV CCCCCCCCCCCCCCC | 30.38 | 19823750 | |
| 303 | Phosphorylation | IRNRNSTSSGQDKVA CCCCCCCCCCCCCCC | 32.09 | 19823750 | |
| 304 | Phosphorylation | RNRNSTSSGQDKVAK CCCCCCCCCCCCCCC | 40.33 | 21440633 | |
| 322 | Phosphorylation | VANETKTSDNGYRNS CCCCCCCCCCCCCCC | 30.54 | 28889911 | |
| 362 | Phosphorylation | DDNRSSVSDKHADIN CCCCHHHHHHHHHHH | 42.78 | 28889911 | |
| 372 | Phosphorylation | HADINRQSKQLDTTD HHHHHHHHHCCCCCC | 21.09 | 19795423 | |
| 377 | Phosphorylation | RQSKQLDTTDDDALS HHHHCCCCCCHHHHH | 40.49 | 22369663 | |
| 378 | Phosphorylation | QSKQLDTTDDDALSY HHHCCCCCCHHHHHH | 36.78 | 22369663 | |
| 384 | Phosphorylation | TTDDDALSYTESIKY CCCHHHHHHHHHCEE | 31.56 | 22369663 | |
| 385 | Phosphorylation | TDDDALSYTESIKYS CCHHHHHHHHHCEEC | 18.51 | 22369663 | |
| 386 | Phosphorylation | DDDALSYTESIKYST CHHHHHHHHHCEECC | 21.63 | 22369663 | |
| 388 | Phosphorylation | DALSYTESIKYSTNE HHHHHHHHCEECCCC | 19.31 | 22369663 | |
| 391 | Phosphorylation | SYTESIKYSTNETEE HHHHHCEECCCCCCC | 21.03 | 28889911 | |
| 396 | Phosphorylation | IKYSTNETEEEDNED CEECCCCCCCCCCCC | 51.25 | 28889911 | |
| 406 | Phosphorylation | EDNEDNESIEDKNED CCCCCCCCCCCCCCC | 37.22 | 28889911 | |
| 416 | Phosphorylation | DKNEDNESIEDENED CCCCCCCCCCCCCCC | 37.22 | 19795423 | |
| 424 | Phosphorylation | IEDENEDTDSYKFSN CCCCCCCCCCCCCCC | 22.21 | 28889911 | |
| 426 | Phosphorylation | DENEDTDSYKFSNRE CCCCCCCCCCCCCCC | 32.11 | 28889911 | |
| 436 | Phosphorylation | FSNREKGSILLTSDE CCCCCCCCEEECCCH | 22.56 | 22890988 | |
| 440 | Phosphorylation | EKGSILLTSDEEEEE CCCCEEECCCHHHHH | 30.59 | 22369663 | |
| 441 | Phosphorylation | KGSILLTSDEEEEEK CCCEEECCCHHHHHH | 42.89 | 22369663 | |
| 451 | Phosphorylation | EEEEKGMSSDSDEGS HHHHHCCCCCCCCCC | 39.40 | 22369663 | |
| 452 | Phosphorylation | EEEKGMSSDSDEGSL HHHHCCCCCCCCCCC | 32.04 | 22369663 | |
| 454 | Phosphorylation | EKGMSSDSDEGSLKA HHCCCCCCCCCCCCC | 39.24 | 22369663 | |
| 458 | Phosphorylation | SSDSDEGSLKAPKSG CCCCCCCCCCCCCCC | 25.34 | 22369663 | |
| 504 | Phosphorylation | SGSELENSDGSDEED CCCCCCCCCCCCCCC | 33.69 | 21551504 | |
| 507 | Phosphorylation | ELENSDGSDEEDHIN CCCCCCCCCCCCCCC | 47.00 | 21551504 | |
| 522 | Phosphorylation | EDKVLEESSVKDSTD HHHHHCCCCCCCCCC | 30.93 | 22369663 | |
| 523 | Phosphorylation | DKVLEESSVKDSTDV HHHHCCCCCCCCCCC | 36.14 | 22369663 | |
| 527 | Phosphorylation | EESSVKDSTDVDSWK CCCCCCCCCCCCCCC | 22.31 | 22369663 | |
| 528 | Phosphorylation | ESSVKDSTDVDSWKP CCCCCCCCCCCCCCC | 50.61 | 22369663 | |
| 532 | Phosphorylation | KDSTDVDSWKPDSEA CCCCCCCCCCCCHHH | 36.53 | 22369663 | |
| 537 | Phosphorylation | VDSWKPDSEALRSGF CCCCCCCHHHHHCCC | 33.04 | 20377248 | |
| 542 | Phosphorylation | PDSEALRSGFVQDTA CCHHHHHCCCCCCCC | 37.12 | 21440633 | |
| 548 | Phosphorylation | RSGFVQDTANKKAPP HCCCCCCCCCCCCCC | 18.29 | 19823750 | |
| 561 | Phosphorylation | PPGYVIDSNGKLVDL CCCEEECCCCCEEEC | 36.04 | 27017623 | |
| 574 | Ubiquitination | DLTPASMKPRVVSTY ECCCCCCCCEEEEEC | 27.46 | 23749301 | |
| 582 | Phosphorylation | PRVVSTYSEMESTWD CEEEEECHHHHHHHH | 30.47 | 27017623 | |
| 593 | Phosphorylation | STWDAFPSKGEDDDL HHHHCCCCCCCCCCH | 47.00 | 24961812 | |
| 602 | Phosphorylation | GEDDDLETIRDTKTI CCCCCHHHHCCCCEE | 28.71 | 28889911 | |
| 606 | Phosphorylation | DLETIRDTKTIYDNN CHHHHCCCCEEECCC | 21.90 | 24961812 | |
| 664 | Phosphorylation | ANDLAARSASFKSEN HHHHHHHHHHHCCCC | 24.44 | 26447709 | |
| 666 | Phosphorylation | DLAARSASFKSENRT HHHHHHHHHCCCCCE | 34.16 | 17563356 | |
| 669 | Phosphorylation | ARSASFKSENRTVSQ HHHHHHCCCCCEECC | 37.79 | 19823750 | |
| 673 | Phosphorylation | SFKSENRTVSQGEMT HHCCCCCEECCCCCC | 35.77 | 22369663 | |
| 675 | Phosphorylation | KSENRTVSQGEMTSV CCCCCEECCCCCCCC | 31.67 | 22369663 | |
| 680 | Phosphorylation | TVSQGEMTSVHEPST EECCCCCCCCCCCCH | 24.24 | 20377248 | |
| 681 | Phosphorylation | VSQGEMTSVHEPSTE ECCCCCCCCCCCCHH | 21.84 | 22369663 | |
| 686 | Phosphorylation | MTSVHEPSTEEMAKL CCCCCCCCHHHHHHH | 45.53 | 22369663 | |
| 687 | Phosphorylation | TSVHEPSTEEMAKLG CCCCCCCHHHHHHHH | 46.83 | 22369663 | |
| 811 | Phosphorylation | KPKDLFASIGKKKL- CHHHHHHHHCCCCC- | 25.25 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FYV8_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FYV8_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FYV8_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56; SER-90; SER-92;TYR-98; SER-100; SER-112; SER-130; SER-134; SER-137; SER-163; SER-180;SER-182; SER-237; SER-238; SER-362; THR-378; SER-384; THR-386; SER-675AND SER-681, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92; SER-100; SER-237;SER-238; SER-280; SER-666 AND SER-681, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100, AND MASSSPECTROMETRY. | |
