| UniProt ID | RGD1_YEAST | |
|---|---|---|
| UniProt AC | P38339 | |
| Protein Name | RHO GTPase-activating protein RGD1 | |
| Gene Name | RGD1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 666 | |
| Subcellular Localization | Cytoplasm . Bud and bud neck. During isotropic bud growth in the G1 and S phases, detected at the bud tip. During cytokinesis, undetectable at the bud tip and localized at the bud neck only. | |
| Protein Description | GTPase activating protein of RHO3 and RHO4. Acts in concert with MID2 in cell integrity, which is functionally linked to the PKC pathway. Involved in various stress responses. Required at low pH for activation of the PKC pathway. Important during mating response.. | |
| Protein Sequence | MEETAKKPASATVSAKSSHDGGTDDLAHLFSTPEIKKVLNSDVAINALLSRLKQSLLTCEEFMKFIRKKYAFEEEHVQELSKQYKHFFNIQGSTNSSLKKMIHEVLGFDGKMAQVKQSYITALQKMYSEISSLLLTMTKLRKSVKENSKRLEKDVSDAIHSAEKAQSRYNSLCQDWDKLRMTDPTKTKLTLRGSKTTKEQEEELLRKIDNADLEYKQKVDHSNSLRNTFITKERPRIVQELKDLILEIDTAMTIQLQKYTIWTENLVLNTGVTISPLDSTKSMKSFAGSVSNERDLYSFLNKYNQTGKHSLLINKNLIPVSYKKHPSMNHGQKNKSPPKFAVDPSRNSIPKRMISTHNESPFLSSSSNTAAVPNANLNSATPSLNTNKQLPPTMASSISSTSNAAGAMSPSSSIVTSDTTSSITKTLDPGNNSPQIPEELINSLDSDRPISHIQTNNNMPPGVQKNFKTFGVPLESLIEFEQDMVPAIVRQCIYVIDKFGLDQEGIYRKSANVLDVSKLKEEIDKDPANISMILPSKPHSDSDIYLVGSLLKTFFASLPDSVLPKALSSEIKVCLQIEDPTTRKNFMHGLIYNLPDAQYWTLRALVFHLKRVLAHEAQNRMNLRALCIIWGPTIAPANPDDANDVNFQIMAMEVLLEVSDQAFEPE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | ETAKKPASATVSAKS CCCCCCCCCEEEECC | 32.76 | 27214570 | |
| 14 | Phosphorylation | KPASATVSAKSSHDG CCCCCEEEECCCCCC | 26.14 | 27214570 | |
| 18 | Phosphorylation | ATVSAKSSHDGGTDD CEEEECCCCCCCCCC | 25.53 | 27214570 | |
| 55 | Phosphorylation | LLSRLKQSLLTCEEF HHHHHHHHHHHHHHH | 24.61 | 22890988 | |
| 58 | Phosphorylation | RLKQSLLTCEEFMKF HHHHHHHHHHHHHHH | 24.14 | 22890988 | |
| 164 | Acetylation | DAIHSAEKAQSRYNS HHHHHHHHHHHHHHH | 51.98 | 24489116 | |
| 190 | Phosphorylation | DPTKTKLTLRGSKTT CCCCCEEEECCCCCC | 18.90 | 27017623 | |
| 194 | Phosphorylation | TKLTLRGSKTTKEQE CEEEECCCCCCHHHH | 22.01 | 28889911 | |
| 279 | Phosphorylation | VTISPLDSTKSMKSF CEECCCCCCCCHHHH | 45.47 | 28889911 | |
| 280 | Phosphorylation | TISPLDSTKSMKSFA EECCCCCCCCHHHHC | 27.14 | 28889911 | |
| 282 | Phosphorylation | SPLDSTKSMKSFAGS CCCCCCCCHHHHCCC | 31.37 | 28889911 | |
| 302 | Acetylation | DLYSFLNKYNQTGKH HHHHHHHHHCCCCCE | 47.96 | 24489116 | |
| 336 | Phosphorylation | NHGQKNKSPPKFAVD CCCCCCCCCCCCCCC | 56.69 | 19684113 | |
| 345 | Phosphorylation | PKFAVDPSRNSIPKR CCCCCCCCCCCCCHH | 39.36 | 28889911 | |
| 348 | Phosphorylation | AVDPSRNSIPKRMIS CCCCCCCCCCHHHHC | 38.87 | 27717283 | |
| 355 | Phosphorylation | SIPKRMISTHNESPF CCCHHHHCCCCCCCC | 17.80 | 21440633 | |
| 356 | Phosphorylation | IPKRMISTHNESPFL CCHHHHCCCCCCCCC | 20.14 | 19779198 | |
| 360 | Phosphorylation | MISTHNESPFLSSSS HHCCCCCCCCCCCCC | 26.69 | 19779198 | |
| 369 | Phosphorylation | FLSSSSNTAAVPNAN CCCCCCCCCCCCCCC | 20.24 | 21440633 | |
| 379 | Phosphorylation | VPNANLNSATPSLNT CCCCCCCCCCCCCCC | 36.36 | 19779198 | |
| 383 | Phosphorylation | NLNSATPSLNTNKQL CCCCCCCCCCCCCCC | 29.87 | 19779198 | |
| 386 | Phosphorylation | SATPSLNTNKQLPPT CCCCCCCCCCCCCCC | 49.43 | 19779198 | |
| 426 | Phosphorylation | TTSSITKTLDPGNNS CCCCCCCCCCCCCCC | 27.95 | 21440633 | |
| 433 | Phosphorylation | TLDPGNNSPQIPEEL CCCCCCCCCCCCHHH | 23.37 | 21440633 | |
| 443 | Phosphorylation | IPEELINSLDSDRPI CCHHHHHHCCCCCCC | 26.93 | 21440633 | |
| 446 | Phosphorylation | ELINSLDSDRPISHI HHHHHCCCCCCCCCC | 40.59 | 21440633 | |
| 451 | Phosphorylation | LDSDRPISHIQTNNN CCCCCCCCCCCCCCC | 19.74 | 21440633 | |
| 455 | Phosphorylation | RPISHIQTNNNMPPG CCCCCCCCCCCCCCC | 39.03 | 21440633 | |
| 553 | Phosphorylation | LVGSLLKTFFASLPD HHHHHHHHHHHCCCC | 24.77 | 29688323 | |
| 557 | Phosphorylation | LLKTFFASLPDSVLP HHHHHHHCCCCCHHC | 34.97 | 29688323 | |
| 561 | Phosphorylation | FFASLPDSVLPKALS HHHCCCCCHHCHHHC | 24.50 | 29688323 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RGD1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RGD1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RGD1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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