ATG20_YEAST - dbPTM
ATG20_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATG20_YEAST
UniProt AC Q07528
Protein Name Autophagy-related protein 20
Gene Name ATG20
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 640
Subcellular Localization Endosome membrane
Peripheral membrane protein. Preautophagosomal structure membrane
Peripheral membrane protein.
Protein Description Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Functions in protein retrieval from the endocytic pathway. Required for proper sorting of the v-SNARE protein SNC1..
Protein Sequence MSDLNDVQENAKLNSETRNTGKAEPPHGTTEYVAEAEISKNGVGSPKKSPKKGKVGKGDNNKVETELVHTALLEKDNPFMEEGPTGFTKSALLEIPGMRSHNLKNPNEDYEDDSEGLLPLNQESNAETCRTSLSGSINSMNGETSASEEPSVSNRKKSARIHILEAKRVSEGQGRAYIAYVIQFENSTVQRRYSDFESLRSILIRLFPMTLIPPIPEKQSIKNYGKSITGSSSKYLLPSEGSGSVDLSLSVIHASVNNSDEKLIRHRIRMLTEFLNKLLTNEEITKTSIITDFLDPNNHNWHEFVNSSSTFSSLPKSILQCNPLDPTNTTRIHAMLPIPGSSSQLLLNKESNDKKMDKERSKSFTNIEQDYKQYENLLDNGIYKYNRRTTKTYHDLKSDYNEIGEVFAQFAHEQAQVGELAEQLSYLSNAFSGSSISLEKLVGRLYYNINEPLNESVHMATSARELIKYRKLKYLQNEMIKKSLNSKRAQLEKLEAQNNEYKDVDKIIDNEMSKSHTINLERPNNNTGSGGKSYGGKLFNGFNKLASMVKDSVKYQETDPHTASINLKKEIEQLSESLEVTENDLEVISKVIKNDQLPKFSKEREVDLSEILKHYSRYMRNYARQNLEIWKEVKRHQDFA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDLNDVQE
------CCCHHHHHH		51.2930377154
2Acetylation------MSDLNDVQE
------CCCHHHHHH		51.2922814378
45PhosphorylationISKNGVGSPKKSPKK
HHCCCCCCCCCCCCC		31.0116445868
49PhosphorylationGVGSPKKSPKKGKVG
CCCCCCCCCCCCCCC		48.3416445868
70PhosphorylationVETELVHTALLEKDN
CCHHHHHHHHHCCCC		16.1224961812
90PhosphorylationGPTGFTKSALLEIPG
CCCCCCHHHHHCCCC		22.5328152593
110PhosphorylationLKNPNEDYEDDSEGL
CCCCCCCCCCCCCCC		18.3228889911
114PhosphorylationNEDYEDDSEGLLPLN
CCCCCCCCCCCCCCC		45.9830377154
131PhosphorylationSNAETCRTSLSGSIN
CCCCHHHHHHCCCHH		35.8529688323
132PhosphorylationNAETCRTSLSGSINS
CCCHHHHHHCCCHHC		10.9423749301
134PhosphorylationETCRTSLSGSINSMN
CHHHHHHCCCHHCCC		30.2029688323
136PhosphorylationCRTSLSGSINSMNGE
HHHHHCCCHHCCCCC		18.4119779198
139PhosphorylationSLSGSINSMNGETSA
HHCCCHHCCCCCCCC		16.3823749301
144PhosphorylationINSMNGETSASEEPS
HHCCCCCCCCCCCCC		30.8723749301
145PhosphorylationNSMNGETSASEEPSV
HCCCCCCCCCCCCCC		26.0423749301
147PhosphorylationMNGETSASEEPSVSN
CCCCCCCCCCCCCCC		42.1129688323
151PhosphorylationTSASEEPSVSNRKKS
CCCCCCCCCCCCCCC		41.2729688323
153PhosphorylationASEEPSVSNRKKSAR
CCCCCCCCCCCCCCE		34.9429688323
218AcetylationLIPPIPEKQSIKNYG
CCCCCCCCHHHHHCC		43.9524489116
361PhosphorylationKKMDKERSKSFTNIE
HHCCHHHHHHCCCHH		33.4717563356
363PhosphorylationMDKERSKSFTNIEQD
CCHHHHHHCCCHHHH		38.2522369663
365PhosphorylationKERSKSFTNIEQDYK
HHHHHHCCCHHHHHH		42.2322369663
371PhosphorylationFTNIEQDYKQYENLL
CCCHHHHHHHHHHHH		10.3319779198
513PhosphorylationKIIDNEMSKSHTINL
HHHCCCHHHCCEEEE		25.4821440633
515PhosphorylationIDNEMSKSHTINLER
HCCCHHHCCEEEEEC		20.6821440633
517PhosphorylationNEMSKSHTINLERPN
CCHHHCCEEEEECCC		20.7424961812
537AcetylationGGKSYGGKLFNGFNK
CCCCHHHHCCCCHHH		45.6125381059
547PhosphorylationNGFNKLASMVKDSVK
CCHHHHHHHHHHHHC		34.2528747907
552PhosphorylationLASMVKDSVKYQETD
HHHHHHHHHCCCCCC		18.1328747907
555PhosphorylationMVKDSVKYQETDPHT
HHHHHHCCCCCCCCC		14.9328747907
562PhosphorylationYQETDPHTASINLKK
CCCCCCCCCCCHHHH		27.7328747907
613AcetylationVDLSEILKHYSRYMR
CCHHHHHHHHHHHHH		46.2724489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATG20_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATG20_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATG20_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SNX4_YEASTSNX4physical
10688190
SNX4_YEASTSNX4physical
12554655
ATG11_YEASTATG11physical
15659643
RRN10_YEASTRRN10physical
15263065
SNX4_YEASTSNX4physical
15263065
YIP1_YEASTYIP1physical
15263065
YIF1_YEASTYIF1physical
15263065
SNX4_YEASTSNX4physical
18467557
TVP15_YEASTTVP15physical
18467557
SNX4_YEASTSNX4physical
18719252
SNX4_YEASTSNX4physical
19591838
PEX13_YEASTPEX13physical
12876220
COG4_YEASTCOG4physical
20065092
VPS51_YEASTVPS51genetic
20861302
YPT6_YEASTYPT6genetic
20861302
ATG21_YEASTATG21genetic
20861302
SNX4_YEASTSNX4physical
22615397
ATG26_YEASTATG26genetic
24586198
SNF1_YEASTSNF1genetic
24586198
ATG23_YEASTATG23genetic
24586198
ATG33_YEASTATG33genetic
24586198
ATG9_YEASTATG9genetic
24586198
CCZ1_YEASTCCZ1genetic
24586198
TOR1_YEASTTOR1genetic
24586198
STU1_YEASTSTU1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
DLDH_YEASTLPD1genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
CDC37_YEASTCDC37genetic
27708008
ACT_YEASTACT1genetic
27708008
STT3_YEASTSTT3genetic
27708008
MET30_YEASTMET30genetic
27708008
PRP19_YEASTPRP19genetic
27708008
ORC1_YEASTORC1genetic
27708008
NOG2_YEASTNOG2genetic
27708008
RPN7_YEASTRPN7genetic
27708008
PEX22_YEASTPEX22genetic
27708008
BUD14_YEASTBUD14genetic
27708008
SWF1_YEASTSWF1genetic
27708008
MKC7_YEASTMKC7genetic
27708008
HSP31_YEASTHSP31genetic
27708008
GET2_YEASTGET2genetic
27708008
TNA1_YEASTTNA1genetic
27708008
OPI1_YEASTOPI1genetic
27708008
SSBP1_YEASTSBP1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
ELM1_YEASTELM1genetic
27708008
VPS51_YEASTVPS51genetic
27708008
YPT6_YEASTYPT6genetic
27708008
COG8_YEASTCOG8genetic
27708008
OCA2_YEASTOCA2genetic
27708008
MKT1_YEASTMKT1genetic
27708008
YP109_YEASTYPL109Cgenetic
27708008
SRO7_YEASTSRO7genetic
27708008
SPEE_YEASTSPE3genetic
27708008
MSS18_YEASTMSS18genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATG20_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361; SER-363 ANDTHR-365, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361; SER-363 ANDTHR-365, AND MASS SPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-49, AND MASSSPECTROMETRY.

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