ATG26_YEAST - dbPTM
ATG26_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATG26_YEAST
UniProt AC Q06321
Protein Name Sterol 3-beta-glucosyltransferase {ECO:0000305|PubMed:10224056}
Gene Name ATG26
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1198
Subcellular Localization Cytoplasm . Membrane
Peripheral membrane protein .
Protein Description Probable sterol 3-beta-glucosyltransferase that is not involved in cytoplasm to vacuole transport (Cvt), pexophagy or nonselective autophagy. [PubMed: 17012830]
Protein Sequence MPITQIISASDSEAGPKPSISLVPDKPSEPETSPRHHRLSRSLSKFKRWRGRSNSSLSMGSSEQQELQDSPNEARSDDDENGYNNDNADDLAKSKYMMKSIAGLLTTASVYAGMNNAQEMNVLSQVDSEESDSSDSFQENIGRNEVKSKKENLKTKSHPEVPRLDKRKPTLFDFSITREKLSKDNVAKLRQRFCLDEQEPFLNDFPAWLLKDVLVQGHIFITTKHFLFFAYLPKNPRSVKMSGNLNIRTKLIRSTRYWCVLKNHLFSMYTSSTELYFPVLTIDLREVQKIETQKHTLNGSATKTFKLYTDESTFKFNADSEFSAKSWVNALKKEQFAAQNSENNSISLKIPLPNIIEIDDQPIVNKALTLRLRALESSQTYAIDDFMFVFMDGSGSQVKESLGEQLAILQKSGVNTLYYDIPAKKSKSSFGKETPATVEQKNNGEDSKYLNVPTSAVPSSENGKKSRFRFRERSNSWFRRAKPLEDSQVEDVEEIYKDAANDIDSSVHSTIHIHEQEDSQEQTVAWKPSHLKNFAEMWAAKPIHYRNKFIPFQKDDTYLIKETEEVSANERFRYHFKFNKEKSLISTYYTYLNRNVPVYGKIYVSNDTVCFRSLLPGSNTYMVLPLVDVETCYKEKGFRFGYFVLVIVIHGHEELFFEFSTEVARDDIERILLKLLDNIYASSAEGSNISSASLGDVQHNPDSAKLKLFEDKINAEGFEVPLMIDENPHYKTSIKPNKSYKFGLLTIGSRGDVQPYIALGKGLIKEGHQVVIITHSEFRDFVESHGIQFEEIAGNPVELMSLMVENESMNVKMLREASSKFRGWIDALLQTSWEVCNRRKFDILIESPSAMVGIHITEALQIPYFRAFTMPWTRTRAYPHAFIVPDQKRGGNYNYLTHVLFENVFWKGISGQVNKWRVETLGLGKTNLFLLQQNNVPFLYNVSPTIFPPSIDFSEWVRVTGYWFLDDKSTFKPPAELQEFISEARSKGKKLVYIGFGSIVVSNAKEMTEALVEAVMEADVYCILNKGWSERLGDKAAKKTEVDLPRNILNIGNVPHDWLFPQVDAAVHHGGSGTTGASLRAGLPTVIKPFFGDQFFYAGRVEDIGVGIALKKLNAQTLADALKVATTNKIMKDRAGLIKKKISKEDGIKTAISAIYNELEYARSVTLSRVKTPRKKEENVDATKLTPAETTDEGWTMI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MPITQIISASD
----CCCEEEEECCC		25.1722369663
8PhosphorylationMPITQIISASDSEAG
CCCEEEEECCCCCCC		24.2922369663
10PhosphorylationITQIISASDSEAGPK
CEEEEECCCCCCCCC		34.5722369663
12PhosphorylationQIISASDSEAGPKPS
EEEECCCCCCCCCCC		27.1822369663
19PhosphorylationSEAGPKPSISLVPDK
CCCCCCCCEEECCCC		30.8222369663
21PhosphorylationAGPKPSISLVPDKPS
CCCCCCEEECCCCCC		27.8721440633
28PhosphorylationSLVPDKPSEPETSPR
EECCCCCCCCCCCCC		72.0922369663
32PhosphorylationDKPSEPETSPRHHRL
CCCCCCCCCCCHHHH		55.5422369663
33PhosphorylationKPSEPETSPRHHRLS
CCCCCCCCCCHHHHH		20.4822369663
40PhosphorylationSPRHHRLSRSLSKFK
CCCHHHHHHHHHHHH		21.5624961812
53PhosphorylationFKRWRGRSNSSLSMG
HHHHCCCCCCCCCCC		43.8423749301
56PhosphorylationWRGRSNSSLSMGSSE
HCCCCCCCCCCCCHH		28.8123749301
58PhosphorylationGRSNSSLSMGSSEQQ
CCCCCCCCCCCHHHH		24.0523749301
70PhosphorylationEQQELQDSPNEARSD
HHHHHHCCCCCCCCC		19.3619779198
76PhosphorylationDSPNEARSDDDENGY
CCCCCCCCCCCCCCC		53.0622369663
128PhosphorylationNVLSQVDSEESDSSD
CCHHCCCCCCCCCCH		44.3928889911
131PhosphorylationSQVDSEESDSSDSFQ
HCCCCCCCCCCHHHH		38.4528889911
157PhosphorylationKENLKTKSHPEVPRL
HHCCCCCCCCCCCCC		49.8928889911
242PhosphorylationNPRSVKMSGNLNIRT
CCCCCCCCCCCCCCH		20.8629734811
249PhosphorylationSGNLNIRTKLIRSTR
CCCCCCCHHHHHHHH		26.8029734811
250AcetylationGNLNIRTKLIRSTRY
CCCCCCHHHHHHHHH		31.8725381059
255PhosphorylationRTKLIRSTRYWCVLK
CHHHHHHHHHHHEEC		20.2321440633
257PhosphorylationKLIRSTRYWCVLKNH
HHHHHHHHHHEECHH		11.8421440633
434PhosphorylationKSSFGKETPATVEQK
CCCCCCCCCCCEECC		23.0028889911
447PhosphorylationQKNNGEDSKYLNVPT
CCCCCCCCCCCCCCC		20.9227017623
474PhosphorylationRFRFRERSNSWFRRA
CCEEHHHCCHHHHCC		30.3821126336
476PhosphorylationRFRERSNSWFRRAKP
EEHHHCCHHHHCCCC		28.9221440633
487PhosphorylationRAKPLEDSQVEDVEE
CCCCCCCCCCCCHHH		27.1024961812
690PhosphorylationSAEGSNISSASLGDV
CCCCCCCCCCCCCCC		24.8919779198
691PhosphorylationAEGSNISSASLGDVQ
CCCCCCCCCCCCCCC		20.3419779198
693PhosphorylationGSNISSASLGDVQHN
CCCCCCCCCCCCCCC		34.5328889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATG26_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATG26_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATG26_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PFD1_YEASTPFD1physical
19536198
HSP72_YEASTSSA2physical
19536198
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
19536198
MDM10_YEASTMDM10genetic
21987634
CBS_YEASTCYS4genetic
21987634
MMM1_YEASTMMM1genetic
21987634
MAS5_YEASTYDJ1genetic
21987634
GLC8_YEASTGLC8genetic
24586198
CCZ1_YEASTCCZ1genetic
24586198
REG1_YEASTREG1genetic
24586198
TOR1_YEASTTOR1genetic
24586198
BECN1_YEASTVPS30genetic
24586198
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATG26_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128; SER-131 ANDSER-476, AND MASS SPECTROMETRY.

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