| UniProt ID | CCZ1_YEAST | |
|---|---|---|
| UniProt AC | P38273 | |
| Protein Name | Vacuolar fusion protein CCZ1 | |
| Gene Name | CCZ1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 704 | |
| Subcellular Localization |
Endosome, multivesicular body membrane Peripheral membrane protein. Prevacuolar compartment membrane Peripheral membrane protein. Vacuole membrane Peripheral membrane protein. The association of the CCZ1-MON1 complex with the vacuole is regulated |
|
| Protein Description | In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.. | |
| Protein Sequence | MRLHYITVFDPSRSTNENDTFKQLLLFHYFGTTDSIPSLNEKLSIIGVIQGIWSLTSSCVNKDGEDLEKIIELNNDIIFCIKVESRFFISLAISNISDDQSAIPLQYLSAYLWLSYRFFKLLNGSFSGFNKDFRKLTDLLNEFVIPFWNDIYLNLETVTNRSFTVMWPGFYKRANFQHSSYNPGEKNNVEESWDAIILQNILLDKKSYLGLKDILVYHLPKRTKAANRESMGTKTYGLVRNFTSDLNTLPDISNWLYHLHCTYGEISSHILTGNVHFKEELQVEEEQERSRDTNGRDEEESQEQQRREHQETTQNNTSELSLSERVIHNVTLPISFAYDAIHEVSTTTGVSGSLSMIMDYVPKPHWPFISSSNKSADKNNYSNSNDNANSNAPLMAQSEAVGGTIGNSRFGFLISPLNSDLLPSSYQALKLNLNFENSKDKEDFYNCLFWYFDDFLIVIVCDPDFNKICERDYLKDLSFQLCQSMECLNNEILNSQNCDNVESFAYVIRDNVTKEIDSSVPFGSPKFTSDESISTLQLAINGIDQFINDNSNSLSLANWNPITIMGGSNAISKKNTTEGFGNGVNDKTQKFKRKYLNFLNLMSAEKLWDLQVDVLQFLTSLQNSKRDPDYFQEERLLKLNNGVLCYIKENNSNLIIIIKNWFQNNGTSKAAKQRNRFSSDSSKGSSLFQSLGRDVTDWWESREI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Phosphorylation | VFDPSRSTNENDTFK EECCCCCCCCCCHHH | 45.50 | 28889911 | |
| 20 | Phosphorylation | RSTNENDTFKQLLLF CCCCCCCHHHHHHHH | 44.29 | 28889911 | |
| 312 | Phosphorylation | QRREHQETTQNNTSE HHHHHHHHHHHCHHH | 27.41 | 22369663 | |
| 313 | Phosphorylation | RREHQETTQNNTSEL HHHHHHHHHHCHHHC | 28.66 | 22369663 | |
| 317 | Phosphorylation | QETTQNNTSELSLSE HHHHHHCHHHCCHHH | 31.00 | 22369663 | |
| 318 | Phosphorylation | ETTQNNTSELSLSER HHHHHCHHHCCHHHH | 38.37 | 22369663 | |
| 321 | Phosphorylation | QNNTSELSLSERVIH HHCHHHCCHHHHHCC | 26.29 | 22369663 | |
| 323 | Phosphorylation | NTSELSLSERVIHNV CHHHCCHHHHHCCCC | 21.71 | 22369663 | |
| 438 | Phosphorylation | LNLNFENSKDKEDFY HHCCCCCCCCHHHHH | 34.73 | 27017623 | |
| 518 | Phosphorylation | NVTKEIDSSVPFGSP CCCCEECCCCCCCCC | 38.61 | 27717283 | |
| 519 | Phosphorylation | VTKEIDSSVPFGSPK CCCEECCCCCCCCCC | 30.02 | 27717283 | |
| 524 | Phosphorylation | DSSVPFGSPKFTSDE CCCCCCCCCCCCCCC | 25.87 | 27717283 | |
| 576 | Phosphorylation | NAISKKNTTEGFGNG CCCCCCCCCCCCCCC | 34.79 | 21551504 | |
| 577 | Phosphorylation | AISKKNTTEGFGNGV CCCCCCCCCCCCCCC | 43.43 | 30377154 | |
| 645 | Glutathionylation | KLNNGVLCYIKENNS HHCCCEEEEEEECCC | 2.83 | 22833525 | |
| 646 | Phosphorylation | LNNGVLCYIKENNSN HCCCEEEEEEECCCC | 15.74 | 21551504 | |
| 678 | Phosphorylation | AKQRNRFSSDSSKGS HHHHHCCCCCCCHHH | 29.96 | 23749301 | |
| 679 | Phosphorylation | KQRNRFSSDSSKGSS HHHHCCCCCCCHHHH | 38.51 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CCZ1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CCZ1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CCZ1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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