ATC2_YEAST - dbPTM
ATC2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATC2_YEAST
UniProt AC P38929
Protein Name Calcium-transporting ATPase 2
Gene Name PMC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1173
Subcellular Localization Vacuole membrane
Multi-pass membrane protein.
Protein Description This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium..
Protein Sequence MSRQDENSALLANNENNKPSYTGNENGVYDNFKLSKSQLSDLHNPKSIRSFVRLFGYESNSLFKYLKTDKNAGISLPEISNYRKTNRYKNYGDNSLPERIPKSFLQLVWAAFNDKTMQLLTVAAVVSFVLGLYELWMQPPQYDPEGNKIKQVDWIEGVAIMIAVFVVVLVSAANDYQKELQFAKLNKKKENRKIIVIRNDQEILISIHHVLVGDVISLQTGDVVPADCVMISGKCEADESSITGESNTIQKFPVDNSLRDFKKFNSIDSHNHSKPLDIGDVNEDGNKIADCMLISGSRILSGLGRGVITSVGINSVYGQTMTSLNAEPESTPLQLHLSQLADNISVYGCVSAIILFLVLFTRYLFYIIPEDGRFHDLDPAQKGSKFMNIFITSITVIVVAVPEGLPLAVTLALAFATTRMTKDGNLVRVLRSCETMGSATAVCSDKTGTLTENVMTVVRGFPGNSKFDDSKSLPVSEQRKLNSKKVFEENCSSSLRNDLLANIVLNSTAFENRDYKKNDKNTNGSKNMSKNLSFLDKCKSRLSFFKKGNREDDEDQLFKNVNKGRQEPFIGSKTETALLSLARLSLGLQPGELQYLRDQPMEKFNIEKVVQTIPFESSRKWAGLVVKYKEGKNKKPFYRFFIKGAAEIVSKNCSYKRNSDDTLEEINEDNKKETDDEIKNLASDALRAISVAHKDFCECDSWPPEQLRDKDSPNIAALDLLFNSQKGLILDGLLGIQDPLRAGVRESVQQCQRAGVTVRMVTGDNILTAKAIARNCAILSTDISSEAYSAMEGTEFRKLTKNERIRILPNLRVLARSSPEDKRLLVETLKGMGDVVAVTGDGTNDAPALKLADVGFSMGISGTEVAREASDIILMTDDFSAIVNAIKWGRCVSVSIKKFIQFQLIVNITAVILTFVSSVASSDETSVLTAVQLLWINLIMDTLAALALATDKPDPNIMDRKPRGRSTSLISVSTWKMILSQATLQLIVTFILHFYGPELFFKKHEDEITSHQQQQLNAMTFNTFVWLQFFTMLVSRKLDEGDGISNWRGRISAANLNFFQDLGRNYYFLTIMAIIGSCQVLIMFFGGAPFSIARQTKSMWITAVLCGMLSLIMGVLVRICPDEVAVKVFPAAFVQRFKYVFGLEFLRKNHTGKHDDEEALLEESDSPESTAFY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMSRQDENSALLANNE
CCCCHHHHCCCCCCC		20.4623749301
18UbiquitinationLANNENNKPSYTGNE
CCCCCCCCCCCCCCC		47.0923749301
50PhosphorylationHNPKSIRSFVRLFGY
CCHHHHHHHHHHHCC		26.8221440633
241PhosphorylationKCEADESSITGESNT
EEECCCCCCCCCCCC		23.3223749301
243PhosphorylationEADESSITGESNTIQ
ECCCCCCCCCCCCEE		36.5227017623
246PhosphorylationESSITGESNTIQKFP
CCCCCCCCCCEEECC		40.3927017623
530UbiquitinationNGSKNMSKNLSFLDK
CCCCCHHHHCHHHHH		51.6523749301
608AcetylationMEKFNIEKVVQTIPF
CHHCCHHHHEEECCC		43.8624489116
608UbiquitinationMEKFNIEKVVQTIPF
CHHCCHHHHEEECCC		43.8623749301
768PhosphorylationVTGDNILTAKAIARN
ECCCCHHHHHHHHHH		23.4724909858
770UbiquitinationGDNILTAKAIARNCA
CCCHHHHHHHHHHCE		34.7823749301
1153UbiquitinationLRKNHTGKHDDEEAL
HHHCCCCCCCCHHHH		45.0424961812
1164PhosphorylationEEALLEESDSPESTA
HHHHHHCCCCCCCCC		33.7324961812
1166PhosphorylationALLEESDSPESTAFY
HHHHCCCCCCCCCCC		39.5924961812
1169PhosphorylationEESDSPESTAFY---
HCCCCCCCCCCC---		28.5524961812
1170PhosphorylationESDSPESTAFY----
CCCCCCCCCCC----		21.0824961812
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATC2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATC2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATC2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CANB_YEASTCNB1genetic
10545454
VCX1_YEASTVCX1genetic
10545454
MEH1_YEASTMEH1physical
18467557
GTR2_YEASTGTR2physical
18467557
VPS68_YEASTVPS68physical
18467557
FMP42_YEASTYMR221Cphysical
18467557
VATH_YEASTVMA13physical
18467557
CTR2_YEASTCTR2physical
18467557
VPH1_YEASTVPH1physical
18467557
COT1_YEASTCOT1physical
18467557
ATG27_YEASTATG27physical
18467557
VATF_YEASTVMA7physical
18467557
NPC1_YEASTNCR1physical
18467557
VPS35_YEASTVPS35physical
18467557
YBT1_YEASTYBT1physical
18467557
YMB8_YEASTYML018Cphysical
18467557
HXT1_YEASTHXT1physical
18467557
HUR1_YEASTHUR1genetic
20093466
ATC1_YEASTPMR1genetic
20093466
SAC1_YEASTSAC1genetic
20093466
YNN4_YEASTYNL134Cgenetic
20093466
CPT1_YEASTCPT1genetic
20093466
YNE0_YEASTYNL040Wgenetic
20093466
SOL1_YEASTSOL1genetic
20093466
VCX1_YEASTVCX1genetic
10026219
VCX1_YEASTVCX1genetic
20709757
VCX1_YEASTVCX1genetic
20735472
MEH1_YEASTMEH1physical
22615397
SPT5_YEASTSPT5physical
22940862
ATC2_YEASTPMC1genetic
25017437
NYV1_YEASTNYV1genetic
25017437
IMG2_YEASTIMG2genetic
27708008
ATC1_YEASTPMR1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
BRE2_YEASTBRE2genetic
27708008
CPT1_YEASTCPT1genetic
27708008
SOL1_YEASTSOL1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATC2_YEAST

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Related Literatures of Post-Translational Modification

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