| UniProt ID | NPC1_YEAST | |
|---|---|---|
| UniProt AC | Q12200 | |
| Protein Name | NPC intracellular cholesterol transporter 1-related protein 1 {ECO:0000305} | |
| Gene Name | NCR1 {ECO:0000312|SGD:S000005927} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1170 | |
| Subcellular Localization |
Vacuole membrane Multi-pass membrane protein . |
|
| Protein Description | Involved in sphingolipid trafficking. May recycle sphingolipids between cellular membranous compartments.. | |
| Protein Sequence | MNVLWIIALVGQLMRLVQGTATCAMYGNCGKKSVFGNELPCPVPRSFEPPVLSDETSKLLVEVCGEEWKEVRYACCTKDQVVALRDNLQKAQPLISSCPACLKNFNNLFCHFTCAADQGRFVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMDLIGGGAKNYSQFLKFLGDAKPMLGGSPFQINYKYDLANEEKEWQEFNDEVYACDDAQYKCACSDCQESCPHLKPLKDGVCKVGPLPCFSLSVLIFYTICALFAFMWYYLCKRKKNGAMIVDDDIVPESGSLDESETNVFESFNNETNFFNGKLANLFTKVGQFSVENPYKILITTVFSIFVFSFIIFQYATLETDPINLWVSKNSEKFKEKEYFDDNFGPFYRTEQIFVVNETGPVLSYETLHWWFDVENFITEELQSSENIGYQDLCFRPTEDSTCVIESFTQYFQGALPNKDSWKRELQECGKFPVNCLPTFQQPLKTNLLFSDDDILNAHAFVVTLLLTNHTQSANRWEERLEEYLLDLKVPEGLRISFNTEISLEKELNNNNDISTVAISYLMMFLYATWALRRKDGKTRLLLGISGLLIVLASIVCAAGFLTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDRNCEQKPEYSIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYEKRSNYKQITGNEETKESFLKTFYFKMLTQKRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVKNLDLTKRQNQQKICGKFTTCERDSLANVLEQERHRSTITEPLANWLDDYFMFLNPQNDQCCRLKKGTDEVCPPSFPSRRCETCFQQGSWNYNMSGFPEGKDFMEYLSIWINAPSDPCPLGGRAPYSTALVYNETSVSASVFRTAHHPLRSQKDFIQAYSDGVRISSSFPELDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVVPSETKKDANSRVLYSLNTIGESVIKGITLTKFIGVCVLAFAQSKIFDVFYFRMWFTLIIVAALHALLFLPALLSLFGGESYRDDSIEAED | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 123 | N-linked_Glycosylation | ADQGRFVNITKVEKS ECCCCEEEEEEEECC | 33.24 | - | |
| 145 | N-linked_Glycosylation | AELDVFMNSSWASEF HEEHHHCCCHHHHHH | 22.79 | - | |
| 178 | N-linked_Glycosylation | LIGGGAKNYSQFLKF HCCCCCCCHHHHHHH | 40.95 | - | |
| 298 | Phosphorylation | DDDIVPESGSLDESE CCCCCCCCCCCCHHH | 27.84 | 29734811 | |
| 300 | Phosphorylation | DIVPESGSLDESETN CCCCCCCCCCHHHCC | 41.76 | 29734811 | |
| 311 | Phosphorylation | SETNVFESFNNETNF HHCCCHHHHCCCCCC | 23.08 | 29734811 | |
| 314 | N-linked_Glycosylation | NVFESFNNETNFFNG CCHHHHCCCCCCCCH | 56.30 | - | |
| 401 | N-linked_Glycosylation | TEQIFVVNETGPVLS EEEEEEECCCCCEEE | 35.49 | - | |
| 513 | N-linked_Glycosylation | VVTLLLTNHTQSANR HHHHHHCCCCCCCCH | 35.86 | - | |
| 794 | Phosphorylation | VDYFKDVYSFLNVGP HHHHHHHHHHHCCCC | 12.11 | 28889911 | |
| 795 | Phosphorylation | DYFKDVYSFLNVGPP HHHHHHHHHHCCCCC | 24.09 | 28889911 | |
| 804 | Phosphorylation | LNVGPPVYMVVKNLD HCCCCCEEEEEECCC | 7.03 | 28889911 | |
| 813 | Phosphorylation | VVKNLDLTKRQNQQK EEECCCCCHHHHHHH | 24.69 | 28889911 | |
| 882 | Phosphorylation | TDEVCPPSFPSRRCE CCCCCCCCCCCCCCH | 34.63 | 28889911 | |
| 885 | Phosphorylation | VCPPSFPSRRCETCF CCCCCCCCCCCHHHC | 30.28 | 28889911 | |
| 900 | N-linked_Glycosylation | QQGSWNYNMSGFPEG CCCCCCCCCCCCCCC | 18.22 | - | |
| 940 | N-linked_Glycosylation | YSTALVYNETSVSAS CCEEEEEECCCCCHH | 38.29 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NPC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NPC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NPC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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