| UniProt ID | CDC25_YEAST | |
|---|---|---|
| UniProt AC | P04821 | |
| Protein Name | Cell division control protein 25 | |
| Gene Name | CDC25 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1589 | |
| Subcellular Localization |
Membrane Single-pass membrane protein . |
|
| Protein Description | Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered.. | |
| Protein Sequence | MSDTNTSIPNTSSAREAGNASQTPSISSSSNTSTTTNTESSSASLSSSPSTSELTSIRPIGIVVAAYDFNYPIKKDSSSQLLSVQQGETIYILNKNSSGWWDGLVIDDSNGKVNRGWFPQNFGRPLRDSHLRKHSHPMKKYSSSKSSRRSSLNSLGNSAYLHVPRNPSKSRRGSSTLSASLSNAHNAETSSGHNNTVSMNNSPFSAPNDASHITPQSSNFNSNASLSQDMTKSADGSSEMNTNAIMNNNETNLQTSGEKAGPPLVAEETIKILPLEEIEMIINGIRSNIASTWSPIPLITKTSDYKLVYYNKDLDIYCSELPLISNSIMESDDICDSEPKFPPNDHLVNLYTRDLRKNANIEDSSTRSKQSESEQNRSSLLMEKQDSKETDGNNNSINDDDNNNENNKNEFNEAGPSSLNSLSAPDLTQNIQSRVVAPSRSSILAKSDIFYHYSRDIKLWTELQDLTVYYTKTAHKMFLKENRLNFTKYFDLISDSIVFTQLGCRLMQHEIKAKSCSKEIKKIFKGLISSLSRISINSHLYFDSAFHRKKMDTMNDKDNDNQENNCSRTEGDDGKIEVDSVHDLVSVPLSGKRNVSTSTTDTLTPMRSSFSTVNENDMENFSVLGPRNSVNSVVTPRTSIQNSTLEDFSPSNKNFKSAKSIYEMVDVEFSKFLRHVQLLYFVLQSSVFSDDNTLPQLLPRFFKGSFSGGSWTNPFSTFITDEFGNATKNKAVTSNEVTASSSKNSSISRIPPKMADAIASASGYSANSETNSQIDLKASSAASGSVFTPFNRPSHNRTFSRARVSKRKKKYPLTVDTLNTMKKKSSQIFEKLNNATGEHLKIISKPKSRIRNLEINSSTYEQINQNVLLLEILENLDLSIFINLKNLIKTPSILLDLESEEFLVHAMSSVSSVLTEFFDIKQAFHDIVIRLIMTTQQTTLDDPYLFSSMRSNFPVGHHEPFKNISNTPLVKGPFHKKNEQLALSLFHVLVSQDVEFNNLEFLNNSDDFKDACEKYVEISNLACIIVDQLIEERENLLNYAARMMKNNLTAELLKGEQEKWFDIYSEDYSDDDSENDEAIIDDELGSEDYIERKAANIEKNLPWFLTSDYETSLVYDSRGKIRGGTKEALIEHLTSHELVDAAFNVTMLITFRSILTTREFFYALIYRYNLYPPEGLSYDDYNIWIEKKSNPIKCRVVNIMRTFLTQYWTRNYYEPGIPLILNFAKMVVSEKIPGAEDLLQKINEKLINENEKEPVDPKQQDSVSAVVQTTKRDNKSPIHMSSSSLPSSASSAFFRLKKLKLLDIDPYTYATQLTVLEHDLYLRITMFECLDRAWGTKYCNMGGSPNITKFIANANTLTNFVSHTIVKQADVKTRSKLTQYFVTVAQHCKELNNFSSMTAIVSALYSSPIYRLKKTWDLVSTESKDLLKNLNNLMDSKRNFVKYRELLRSVTDVACVPFFGVYLSDLTFTFVGNPDFLHNSTNIINFSKRTKIANIVEEIISFKRFHYKLKRLDDIQTVIEASLENVPHIEKQYQLSLQVEPRSGNTKGSTHASSASGTKTAKFLSEFTDDKNGNFLKLGKKKPPSRLFR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSDTNTSIP ------CCCCCCCCC | 65.53 | 22369663 | |
| 4 | Phosphorylation | ----MSDTNTSIPNT ----CCCCCCCCCCC | 50.08 | 22369663 | |
| 6 | Phosphorylation | --MSDTNTSIPNTSS --CCCCCCCCCCCHH | 30.08 | 22369663 | |
| 7 | Phosphorylation | -MSDTNTSIPNTSSA -CCCCCCCCCCCHHH | 37.81 | 22369663 | |
| 11 | Phosphorylation | TNTSIPNTSSAREAG CCCCCCCCHHHHHCC | 20.78 | 22369663 | |
| 12 | Phosphorylation | NTSIPNTSSAREAGN CCCCCCCHHHHHCCC | 28.74 | 22369663 | |
| 13 | Phosphorylation | TSIPNTSSAREAGNA CCCCCCHHHHHCCCC | 29.34 | 22369663 | |
| 77 | Phosphorylation | NYPIKKDSSSQLLSV CCCCCCCCCCCCEEE | 40.54 | 10529198 | |
| 135 | Phosphorylation | DSHLRKHSHPMKKYS HHHHHHCCCCCHHCC | 32.11 | 10529198 | |
| 142 | Phosphorylation | SHPMKKYSSSKSSRR CCCCHHCCCCHHHHH | 36.69 | 10529198 | |
| 146 | Phosphorylation | KKYSSSKSSRRSSLN HHCCCCHHHHHHHCH | 30.90 | 19823750 | |
| 147 | Phosphorylation | KYSSSKSSRRSSLNS HCCCCHHHHHHHCHH | 35.13 | 24961812 | |
| 150 | Phosphorylation | SSKSSRRSSLNSLGN CCHHHHHHHCHHCCC | 37.76 | 22369663 | |
| 151 | Phosphorylation | SKSSRRSSLNSLGNS CHHHHHHHCHHCCCC | 29.74 | 22369663 | |
| 154 | Phosphorylation | SRRSSLNSLGNSAYL HHHHHCHHCCCCEEE | 42.84 | 22369663 | |
| 158 | Phosphorylation | SLNSLGNSAYLHVPR HCHHCCCCEEEECCC | 19.25 | 22369663 | |
| 160 | Phosphorylation | NSLGNSAYLHVPRNP HHCCCCEEEECCCCC | 9.36 | 29688323 | |
| 168 | Phosphorylation | LHVPRNPSKSRRGSS EECCCCCCCCCCCCC | 46.97 | 19823750 | |
| 174 | Phosphorylation | PSKSRRGSSTLSASL CCCCCCCCCCHHHHH | 20.52 | 10529198 | |
| 222 | Phosphorylation | PQSSNFNSNASLSQD CCCCCCCCCCCCCCC | 29.63 | 28889911 | |
| 233 | Phosphorylation | LSQDMTKSADGSSEM CCCCCCCCCCCCCCC | 23.56 | 27017623 | |
| 238 | Phosphorylation | TKSADGSSEMNTNAI CCCCCCCCCCCHHHH | 46.52 | 25752575 | |
| 242 | Phosphorylation | DGSSEMNTNAIMNNN CCCCCCCHHHHHCCC | 25.39 | 27017623 | |
| 309 | Phosphorylation | TSDYKLVYYNKDLDI CCCCEEEEECCCCCE | 16.26 | 29688323 | |
| 310 | Phosphorylation | SDYKLVYYNKDLDIY CCCEEEEECCCCCEE | 14.30 | 29688323 | |
| 317 | Phosphorylation | YNKDLDIYCSELPLI ECCCCCEEECCCCCC | 6.92 | 29688323 | |
| 319 | Phosphorylation | KDLDIYCSELPLISN CCCCEEECCCCCCCC | 25.79 | 29688323 | |
| 325 | Phosphorylation | CSELPLISNSIMESD ECCCCCCCCCCCCCC | 32.01 | 29688323 | |
| 327 | Phosphorylation | ELPLISNSIMESDDI CCCCCCCCCCCCCCC | 19.27 | 29688323 | |
| 331 | Phosphorylation | ISNSIMESDDICDSE CCCCCCCCCCCCCCC | 24.17 | 29688323 | |
| 337 | Phosphorylation | ESDDICDSEPKFPPN CCCCCCCCCCCCCCC | 51.92 | 29688323 | |
| 365 | Phosphorylation | NANIEDSSTRSKQSE HCCCCCCCCCCCCCH | 39.91 | 28889911 | |
| 373 | Phosphorylation | TRSKQSESEQNRSSL CCCCCCHHHHHHHHH | 50.13 | 21551504 | |
| 378 | Phosphorylation | SESEQNRSSLLMEKQ CHHHHHHHHHHHHHH | 32.65 | 21440633 | |
| 379 | Phosphorylation | ESEQNRSSLLMEKQD HHHHHHHHHHHHHHC | 23.45 | 28889911 | |
| 390 | Phosphorylation | EKQDSKETDGNNNSI HHHCCCCCCCCCCCC | 53.60 | 27717283 | |
| 396 | Phosphorylation | ETDGNNNSINDDDNN CCCCCCCCCCCCCCC | 25.54 | 25521595 | |
| 417 | Phosphorylation | EFNEAGPSSLNSLSA CCCCCCHHHHHHCCC | 46.68 | 19795423 | |
| 418 | Phosphorylation | FNEAGPSSLNSLSAP CCCCCHHHHHHCCCC | 34.40 | 22369663 | |
| 421 | Phosphorylation | AGPSSLNSLSAPDLT CCHHHHHHCCCCCHH | 29.06 | 25521595 | |
| 423 | Phosphorylation | PSSLNSLSAPDLTQN HHHHHHCCCCCHHHH | 37.26 | 22369663 | |
| 428 | Phosphorylation | SLSAPDLTQNIQSRV HCCCCCHHHHHHHHC | 27.27 | 22369663 | |
| 433 | Phosphorylation | DLTQNIQSRVVAPSR CHHHHHHHHCCCCCH | 24.20 | 24961812 | |
| 439 | Phosphorylation | QSRVVAPSRSSILAK HHHCCCCCHHHHHHH | 34.75 | 24961812 | |
| 441 | Phosphorylation | RVVAPSRSSILAKSD HCCCCCHHHHHHHCC | 26.52 | 24961812 | |
| 442 | Phosphorylation | VVAPSRSSILAKSDI CCCCCHHHHHHHCCH | 22.10 | 24961812 | |
| 461 | Phosphorylation | SRDIKLWTELQDLTV CCCCHHHHHHHHCEE | 36.94 | 30377154 | |
| 469 | Phosphorylation | ELQDLTVYYTKTAHK HHHHCEEEEHHHHHH | 10.53 | 30377154 | |
| 473 | Phosphorylation | LTVYYTKTAHKMFLK CEEEEHHHHHHHHHH | 26.62 | 30377154 | |
| 525 | Acetylation | KEIKKIFKGLISSLS HHHHHHHHHHHHHHH | 57.17 | 24489116 | |
| 530 | Phosphorylation | IFKGLISSLSRISIN HHHHHHHHHHCCEEC | 24.30 | 27017623 | |
| 557 | Ubiquitination | KMDTMNDKDNDNQEN HCCCCCCCCCCCCCC | 54.12 | 23749301 | |
| 567 | Phosphorylation | DNQENNCSRTEGDDG CCCCCCCCCCCCCCC | 44.34 | 21551504 | |
| 569 | Phosphorylation | QENNCSRTEGDDGKI CCCCCCCCCCCCCCE | 28.20 | 19779198 | |
| 580 | Phosphorylation | DGKIEVDSVHDLVSV CCCEEECEEEEEEEC | 26.91 | 20377248 | |
| 590 | Phosphorylation | DLVSVPLSGKRNVST EEEECCCCCCCCCCC | 35.88 | 28889911 | |
| 596 | Phosphorylation | LSGKRNVSTSTTDTL CCCCCCCCCCCCCCC | 21.86 | 27738172 | |
| 597 | Phosphorylation | SGKRNVSTSTTDTLT CCCCCCCCCCCCCCC | 26.30 | 19779198 | |
| 598 | Phosphorylation | GKRNVSTSTTDTLTP CCCCCCCCCCCCCCC | 23.08 | 23749301 | |
| 599 | Phosphorylation | KRNVSTSTTDTLTPM CCCCCCCCCCCCCCC | 28.87 | 21440633 | |
| 600 | Phosphorylation | RNVSTSTTDTLTPMR CCCCCCCCCCCCCCH | 27.10 | 25752575 | |
| 604 | Phosphorylation | TSTTDTLTPMRSSFS CCCCCCCCCCHHCCC | 19.68 | 23749301 | |
| 608 | Phosphorylation | DTLTPMRSSFSTVNE CCCCCCHHCCCCCCH | 29.50 | 21440633 | |
| 609 | Phosphorylation | TLTPMRSSFSTVNEN CCCCCHHCCCCCCHH | 16.92 | 19779198 | |
| 611 | Phosphorylation | TPMRSSFSTVNENDM CCCHHCCCCCCHHHC | 33.13 | 19779198 | |
| 612 | Phosphorylation | PMRSSFSTVNENDME CCHHCCCCCCHHHCC | 25.91 | 29734811 | |
| 629 | Phosphorylation | SVLGPRNSVNSVVTP EEECCCCCCCCCCCC | 24.77 | 25752575 | |
| 632 | Phosphorylation | GPRNSVNSVVTPRTS CCCCCCCCCCCCCCC | 18.79 | 22369663 | |
| 635 | Phosphorylation | NSVNSVVTPRTSIQN CCCCCCCCCCCCCCC | 12.61 | 22369663 | |
| 638 | Phosphorylation | NSVVTPRTSIQNSTL CCCCCCCCCCCCCCC | 31.24 | 17330950 | |
| 639 | Phosphorylation | SVVTPRTSIQNSTLE CCCCCCCCCCCCCCC | 24.37 | 25752575 | |
| 643 | Phosphorylation | PRTSIQNSTLEDFSP CCCCCCCCCCCCCCC | 20.28 | 17330950 | |
| 644 | Phosphorylation | RTSIQNSTLEDFSPS CCCCCCCCCCCCCCC | 41.54 | 28889911 | |
| 649 | Phosphorylation | NSTLEDFSPSNKNFK CCCCCCCCCCCCCCC | 39.48 | 22369663 | |
| 651 | Phosphorylation | TLEDFSPSNKNFKSA CCCCCCCCCCCCCCH | 60.27 | 22369663 | |
| 653 | Acetylation | EDFSPSNKNFKSAKS CCCCCCCCCCCCHHH | 69.01 | 24489116 | |
| 653 | Ubiquitination | EDFSPSNKNFKSAKS CCCCCCCCCCCCHHH | 69.01 | 23749301 | |
| 660 | Phosphorylation | KNFKSAKSIYEMVDV CCCCCHHHHHHHHCH | 30.07 | 25704821 | |
| 733 | Phosphorylation | ATKNKAVTSNEVTAS CCCCCCCCCCCCCCC | 30.60 | 19823750 | |
| 734 | Phosphorylation | TKNKAVTSNEVTASS CCCCCCCCCCCCCCC | 25.13 | 25752575 | |
| 738 | Phosphorylation | AVTSNEVTASSSKNS CCCCCCCCCCCCCCC | 18.04 | 22369663 | |
| 740 | Phosphorylation | TSNEVTASSSKNSSI CCCCCCCCCCCCCCC | 26.27 | 22369663 | |
| 741 | Phosphorylation | SNEVTASSSKNSSIS CCCCCCCCCCCCCCC | 42.75 | 22369663 | |
| 742 | Phosphorylation | NEVTASSSKNSSISR CCCCCCCCCCCCCCC | 33.10 | 22369663 | |
| 745 | Phosphorylation | TASSSKNSSISRIPP CCCCCCCCCCCCCCH | 32.55 | 23749301 | |
| 746 | Phosphorylation | ASSSKNSSISRIPPK CCCCCCCCCCCCCHH | 33.70 | 20377248 | |
| 748 | Phosphorylation | SSKNSSISRIPPKMA CCCCCCCCCCCHHHH | 26.55 | 19823750 | |
| 760 | Phosphorylation | KMADAIASASGYSAN HHHHHHHHHCCCCCC | 19.49 | 30377154 | |
| 762 | Phosphorylation | ADAIASASGYSANSE HHHHHHHCCCCCCCC | 35.45 | 30377154 | |
| 764 | Phosphorylation | AIASASGYSANSETN HHHHHCCCCCCCCCC | 11.34 | 21551504 | |
| 765 | Phosphorylation | IASASGYSANSETNS HHHHCCCCCCCCCCC | 25.21 | 22369663 | |
| 768 | Phosphorylation | ASGYSANSETNSQID HCCCCCCCCCCCCEE | 45.58 | 22369663 | |
| 770 | Phosphorylation | GYSANSETNSQIDLK CCCCCCCCCCCEEHH | 39.74 | 22369663 | |
| 772 | Phosphorylation | SANSETNSQIDLKAS CCCCCCCCCEEHHHC | 35.61 | 22369663 | |
| 780 | Phosphorylation | QIDLKASSAASGSVF CEEHHHCHHCCCCCC | 32.49 | 21082442 | |
| 783 | Phosphorylation | LKASSAASGSVFTPF HHHCHHCCCCCCCCC | 31.17 | 21082442 | |
| 825 | Phosphorylation | LNTMKKKSSQIFEKL HHHCHHHHHHHHHHH | 36.03 | 10529198 | |
| 826 | Phosphorylation | NTMKKKSSQIFEKLN HHCHHHHHHHHHHHH | 35.85 | 10529198 | |
| 965 | Phosphorylation | HEPFKNISNTPLVKG CCCCCCCCCCCCCCC | 44.00 | 19823750 | |
| 967 | Phosphorylation | PFKNISNTPLVKGPF CCCCCCCCCCCCCCC | 15.94 | 19795423 | |
| 1252 | Ubiquitination | KLINENEKEPVDPKQ HHCCCCCCCCCCHHH | 78.04 | 23749301 | |
| 1262 | Phosphorylation | VDPKQQDSVSAVVQT CCHHHHHCHHHHEEE | 17.40 | 22890988 | |
| 1264 | Phosphorylation | PKQQDSVSAVVQTTK HHHHHCHHHHEEECC | 21.21 | 22890988 | |
| 1269 | Phosphorylation | SVSAVVQTTKRDNKS CHHHHEEECCCCCCC | 23.75 | 22890988 | |
| 1270 | Phosphorylation | VSAVVQTTKRDNKSP HHHHEEECCCCCCCC | 13.64 | 22890988 | |
| 1276 | Phosphorylation | TTKRDNKSPIHMSSS ECCCCCCCCCEECCC | 35.03 | 25752575 | |
| 1281 | Phosphorylation | NKSPIHMSSSSLPSS CCCCCEECCCCCCCC | 16.95 | 21440633 | |
| 1282 | Phosphorylation | KSPIHMSSSSLPSSA CCCCEECCCCCCCCC | 19.17 | 28889911 | |
| 1283 | Phosphorylation | SPIHMSSSSLPSSAS CCCEECCCCCCCCCC | 28.70 | 21440633 | |
| 1284 | Phosphorylation | PIHMSSSSLPSSASS CCEECCCCCCCCCCH | 46.37 | 21440633 | |
| 1288 | Phosphorylation | SSSSLPSSASSAFFR CCCCCCCCCCHHHHH | 30.17 | 21440633 | |
| 1290 | Phosphorylation | SSLPSSASSAFFRLK CCCCCCCCHHHHHHH | 24.93 | 21440633 | |
| 1443 | Phosphorylation | SKRNFVKYRELLRSV HHHHHHHHHHHHHHC | 12.20 | 22369663 | |
| 1501 | Phosphorylation | NIVEEIISFKRFHYK HHHHHHHHHHHHHHH | 30.31 | 24961812 | |
| 1565 | Phosphorylation | TKTAKFLSEFTDDKN CCCHHHHHHHCCCCC | 33.52 | 27017623 | |
| 1585 | Phosphorylation | LGKKKPPSRLFR--- CCCCCCCHHCCC--- | 50.58 | 2176715 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CDC25_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDC25_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDC25_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151; SER-154; SER-222;SER-423; SER-596; SER-639; SER-649; SER-651 AND SER-768, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151 AND SER-154, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-635, AND MASSSPECTROMETRY. | |
