dbPTM

OPT2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OPT2_YEAST
UniProt AC	Q06593
Protein Name	Oligopeptide transporter 2
Gene Name	OPT2
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	877
Subcellular Localization	Membrane Multi-pass membrane protein.
Protein Description	Transports tetra- and pentapeptides. Does not transport glutathione..
Protein Sequence	MSETVKDKVIIDEKVSTKGTVDYAEGAEYSERLSNHSSDFSQWYTDEQILHFMKKLGYENRTLYDIPEDVAYILKKMPELTLEDSFKILKDSIIYFKDDENIPHDQYEEWKRLVDLEDLDSKEGIDEYDSFDIRAFASAIKFHSPYQEVRAVVDPEDDPTIPVETFRAYFLAIIWSVIGSGFNEFFSHRVVSISLNTPIIQMFLYICGKAWAKTIPCWTITIRGRKYGINIDKPWTQKEQMFSTLLYAICQGAFYTHYNILTQKLFYHSAFSFGYQFLLSLSVQFIGFGFAGILRKFVVYPARALWPTVMPTIAINKALLGKEKHESGMSRYKFFFLTFFIMFIYNWFPTYIINILNTFNWMTWIKPSNINLANITGGVTGLGINPISSFDWNVISFNSPLVYPFWSYLTQYLGCILAALIVIAVYYSNYMSCQYLPIFTNSLYTNTGHSFKVTEVLDSDNKLDVKKYQSYSPPYYSAGNLVSYGAFICAYPLMITWSFIVHSKLLFNAFKDWALNLWAMRKLKSWVTMFKSDYRALDDYDDPHSNAMKNYKEVPDWWYFAILIGSLVVGIAVVEHYPTNTPVWGLFVCLGFNFVFLIPTTILQATTGYSFGLNLLIEMVMGYALPGNPIAIMILKAFGYNIDGQADNYVSNLKIAHYCKIPPMALFRGQCVIVFIQIFVNLGVLNWQISNIKDFCTPHQNAKFTCPDAVTYYNASVVWGAIGPKRIFNYIYPIFKWCWLIGACIGIFFGVWKRWGKFYPRYFDPMLFVGGMLNMSPPYNLMYYTSGMIVSYISQYYMKRHHLNLWEKYNYVLSAGFSTGLVLSAIIIFFAVQYKDTAFNWWGNTVPYAGADGVGYPLKNITDTANGYFGYAPGHYP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	VIIDEKVSTKGTVDY EEECCCCCCCCCCCH	35.15	24961812
17	Phosphorylation	IIDEKVSTKGTVDYA EECCCCCCCCCCCHH	36.16	24961812
75	Ubiquitination	EDVAYILKKMPELTL HHHHHHHHHCCCCCH	37.15	17644757
76	Ubiquitination	DVAYILKKMPELTLE HHHHHHHHCCCCCHH	57.13	17644757
92	Phosphorylation	SFKILKDSIIYFKDD HHHHHHCCEEEEECC	14.86	27017623
95	Phosphorylation	ILKDSIIYFKDDENI HHHCCEEEEECCCCC	11.69	27017623
107	Phosphorylation	ENIPHDQYEEWKRLV CCCCHHHHHHHHHHC	23.13	27017623
141	Ubiquitination	RAFASAIKFHSPYQE HHHHHHHCCCCCCCC	36.42	17644757
374	N-linked_Glycosylation	PSNINLANITGGVTG CCCCEECCCCCCCCC	35.21	-
860	N-linked_Glycosylation	GVGYPLKNITDTANG CCCCCCCCCCCCCCC	50.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of OPT2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of OPT2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OPT2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ODPA_YEAST	PDA1	genetic	20093466
MGR2_YEAST	MGR2	genetic	20093466
PHO88_YEAST	PHO88	physical	16093310
MKAR_YEAST	IFA38	physical	16093310
EMP24_YEAST	EMP24	physical	16093310
HXT4_YEAST	HXT4	physical	16093310
ELO3_YEAST	ELO3	physical	16093310
ATPN_YEAST	ATP20	physical	16093310
CATA_YEAST	CTA1	genetic	25130273
EXO5_YEAST	EXO5	genetic	25130273
RM11_YEAST	MRPL11	genetic	25130273
SYWM_YEAST	MSW1	genetic	25130273
EMI1_YEAST	EMI1	genetic	25130273
AVT2_YEAST	AVT2	genetic	25130273
BMH1_YEAST	BMH1	genetic	25130273
ITC1_YEAST	ITC1	genetic	25130273
MRM2_YEAST	MRM2	genetic	25130273
RM25_YEAST	MRPL25	genetic	25130273
RSSA1_YEAST	RPS0A	genetic	25130273
STB5_YEAST	STB5	genetic	25130273
SYS1_YEAST	SYS1	genetic	25130273
RM38_YEAST	MRPL38	genetic	25130273
RM20_YEAST	MRPL20	genetic	25130273
VDAC1_YEAST	POR1	genetic	25130273
PALA_YEAST	RIM20	genetic	25130273
RS12_YEAST	RPS12	genetic	25130273
RM40_YEAST	MRPL40	genetic	25130273
SYFM_YEAST	MSF1	genetic	25130273
ARR3_YEAST	ARR3	genetic	25130273
SIT1_YEAST	SIT1	genetic	25130273
SYPM_YEAST	AIM10	genetic	25130273
ODPA_YEAST	PDA1	genetic	25130273
RF1M_YEAST	MRF1	genetic	25130273
ZUO1_YEAST	ZUO1	genetic	25130273
RL34B_YEAST	RPL34B	genetic	25130273
HPM1_YEAST	HPM1	genetic	25130273
RL39_YEAST	RPL39	genetic	25130273
GEF1_YEAST	GEF1	genetic	25130273
SWI6_YEAST	SWI6	genetic	25130273
LIPB_YEAST	LIP2	genetic	25130273
FET3_YEAST	FET3	genetic	25130273
IST1_YEAST	IST1	genetic	25130273
VPS4_YEAST	VPS4	genetic	25130273
ODPA_YEAST	PDA1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OPT2_YEAST

Related Literatures of Post-Translational Modification