MRM2_YEAST - dbPTM
MRM2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MRM2_YEAST
UniProt AC P53123
Protein Name rRNA methyltransferase 2, mitochondrial {ECO:0000303|PubMed:11867542}
Gene Name MRM2 {ECO:0000303|PubMed:11867542}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 320
Subcellular Localization Mitochondrion .
Protein Description S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 2791 (Um2791) in the 21S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA..
Protein Sequence MILVYNRIRSIISSSLGRIHVRYNSNSQNRWLNRQLKDPYTKEAKVQNLRSRAAFKLMQIDDKYRLFSKNRTDQRILDLGYAPGAWSQVARQRSSPNSMILGVDILPCEPPHGVNSIQANILAKRTHDLIRLFFSKHFQLNRHDDLHKDHGYFQNMLEEELTHVKDTELYREIFTSDDIYETPNTNSTLIEREKFPVDVIISDMYEPWPQTTGFWNNITNQAYFRMANTSGVSIRDHYQSIDLCDAALVTAIDLLRPLGSFVCKLYTGEEENLFKKRMQAVFTNVHKFKPDASRDESKETYYIGLKKKRNVDKLDVFSNS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationNRIRSIISSSLGRIH
HHHHHHHHHCCCCEE		16.5328889911
63AcetylationKLMQIDDKYRLFSKN
HHCCCCHHHHHHCCC		28.6424489116
318PhosphorylationVDKLDVFSNS-----
CCCCCCCCCC-----		35.6928889911
320PhosphorylationKLDVFSNS-------
CCCCCCCC-------		40.1628889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MRM2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MRM2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MRM2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MTG2_YEASTMTG2genetic
15591131
SQT1_YEASTSQT1genetic
19061648
PRP2_YEASTPRP2genetic
19061648
GNA1_YEASTGNA1genetic
27708008
STE50_YEASTSTE50genetic
27708008
PRP9_YEASTPRP9genetic
27708008
TAF12_YEASTTAF12genetic
27708008
UTP6_YEASTUTP6genetic
27708008
SAD1_YEASTSAD1genetic
27708008
PSB7_YEASTPRE4genetic
27708008
TIM14_YEASTPAM18genetic
27708008
SEC22_YEASTSEC22genetic
27708008
PSB2_YEASTPUP1genetic
27708008
PSA7_YEASTPRE10genetic
27708008
ICS2_YEASTICS2genetic
27708008
SGF29_YEASTSGF29genetic
27708008
CEM1_YEASTCEM1genetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
LPLA_YEASTAIM22genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
FABG_YEASTOAR1genetic
27708008
LIPB_YEASTLIP2genetic
27708008
ATP18_YEASTATP18genetic
27708008
PET8_YEASTPET8genetic
27708008
LIPA_YEASTLIP5genetic
27708008
HAP5_YEASTHAP5genetic
27708008
POC4_YEASTPOC4genetic
27708008
PET20_YEASTPET20genetic
27708008
RU2A_YEASTLEA1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MRM2_YEAST

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Related Literatures of Post-Translational Modification

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