| UniProt ID | SEC22_YEAST | |
|---|---|---|
| UniProt AC | P22214 | |
| Protein Name | Protein transport protein SEC22 | |
| Gene Name | SEC22 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 214 | |
| Subcellular Localization |
Membrane Single-pass type IV membrane protein . Endoplasmic reticulum membrane Single-pass type IV membrane protein . Golgi apparatus membrane Single-pass type IV membrane protein . |
|
| Protein Description | Nonessential SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.. | |
| Protein Sequence | MIKSTLIYREDGLPLCTSVDNENDPSLFEQKQKVKIVVSRLTPQSATEATLESGSFEIHYLKKSMVYYFVICESGYPRNLAFSYLNDIAQEFEHSFANEYPKPTVRPYQFVNFDNFLQMTKKSYSDKKVQDNLDQLNQELVGVKQIMSKNIEDLLYRGDSLDKMSDMSSSLKETSKRYRKSAQKINFDLLISQYAPIVIVAFFFVFLFWWIFLK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MIKSTLIYREDGLPL CCCCEEEEECCCCEE | 15.86 | 28889911 | |
| 144 | Ubiquitination | NQELVGVKQIMSKNI HHHHHHHHHHHCCCH | 28.33 | 23749301 | |
| 144 | Acetylation | NQELVGVKQIMSKNI HHHHHHHHHHHCCCH | 28.33 | 24489116 | |
| 149 | Acetylation | GVKQIMSKNIEDLLY HHHHHHCCCHHHHHH | 44.56 | 24489116 | |
| 156 | Phosphorylation | KNIEDLLYRGDSLDK CCHHHHHHCCCCHHH | 21.61 | 22369663 | |
| 160 | Phosphorylation | DLLYRGDSLDKMSDM HHHHCCCCHHHHHHH | 41.09 | 22369663 | |
| 165 | Phosphorylation | GDSLDKMSDMSSSLK CCCHHHHHHHHHHHH | 35.58 | 21440633 | |
| 172 | Ubiquitination | SDMSSSLKETSKRYR HHHHHHHHHHHHHHH | 61.98 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEC22_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEC22_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEC22_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, AND MASSSPECTROMETRY. | |
