| UniProt ID | KC11_YEAST | |
|---|---|---|
| UniProt AC | P23291 | |
| Protein Name | Casein kinase I homolog 1 | |
| Gene Name | YCK1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 538 | |
| Subcellular Localization |
Cell membrane Lipid-anchor . |
|
| Protein Description | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.. | |
| Protein Sequence | MSMPIASTTLAVNNLTNINGNANFNVQANKQLHHQAVDSPARSSMTATTAANSNSNSSRDDSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRSTNVYDLAQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLSVLDDLGETADGQYDWMKLNDGRGWDLNINKKPNLHGYGHPNPPNEKSRKHRNKQLQMQQLQMQQLQQQQQQQQYAQKTEADMRNSQYKPKLDPTSYEAYQHQTQQKYLQEQQKRQQQQKLQEQQLQEQQLQQQQQQQQQLRATGQPPSQPQAQTQSQQFGARYQPQQQPSAALRTPEQHPNDDNSSLAASHKGFFQKLGCC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 39 | Phosphorylation | LHHQAVDSPARSSMT HCHHCCCCCCCCCCH | 17.54 | 24909858 | |
| 43 | Phosphorylation | AVDSPARSSMTATTA CCCCCCCCCCHHCCC | 26.94 | 22890988 | |
| 44 | Phosphorylation | VDSPARSSMTATTAA CCCCCCCCCHHCCCC | 18.01 | 22890988 | |
| 46 | Phosphorylation | SPARSSMTATTAANS CCCCCCCHHCCCCCC | 23.85 | 22890988 | |
| 48 | Phosphorylation | ARSSMTATTAANSNS CCCCCHHCCCCCCCC | 14.06 | 22890988 | |
| 49 | Phosphorylation | RSSMTATTAANSNSN CCCCHHCCCCCCCCC | 22.70 | 22890988 | |
| 53 | Phosphorylation | TATTAANSNSNSSRD HHCCCCCCCCCCCCC | 36.59 | 22890988 | |
| 55 | Phosphorylation | TTAANSNSNSSRDDS CCCCCCCCCCCCCCC | 37.60 | 22890988 | |
| 57 | Phosphorylation | AANSNSNSSRDDSTI CCCCCCCCCCCCCEE | 26.94 | 22890988 | |
| 58 | Phosphorylation | ANSNSNSSRDDSTIV CCCCCCCCCCCCEEE | 43.93 | 22890988 | |
| 62 | Phosphorylation | SNSSRDDSTIVGLHY CCCCCCCCEEEEEEE | 25.07 | 22369663 | |
| 63 | Phosphorylation | NSSRDDSTIVGLHYK CCCCCCCEEEEEEEE | 27.03 | 22369663 | |
| 69 | Phosphorylation | STIVGLHYKIGKKIG CEEEEEEEEECCCCC | 14.89 | 24961812 | |
| 103 | Ubiquitination | AIKFEPRKTEAPQLR EEEECCCCCCCCCCH | 62.52 | 23749301 | |
| 236 | Phosphorylation | YREKKSLSGTARYMS CCHHCCCCCCCEEEH | 40.98 | 23749301 | |
| 386 | Ubiquitination | PPNEKSRKHRNKQLQ CCCHHHHHHHHHHHH | 54.74 | 22817900 | |
| 390 | Ubiquitination | KSRKHRNKQLQMQQL HHHHHHHHHHHHHHH | 52.95 | 23749301 | |
| 414 | Ubiquitination | QQQQYAQKTEADMRN HHHHHHHHHHHHHHH | 39.91 | 23749301 | |
| 415 | Phosphorylation | QQQYAQKTEADMRNS HHHHHHHHHHHHHHC | 25.07 | 22369663 | |
| 422 | Phosphorylation | TEADMRNSQYKPKLD HHHHHHHCCCCCCCC | 25.23 | 22369663 | |
| 424 | Phosphorylation | ADMRNSQYKPKLDPT HHHHHCCCCCCCCCC | 29.13 | 22369663 | |
| 427 | Acetylation | RNSQYKPKLDPTSYE HHCCCCCCCCCCHHH | 62.46 | 24489116 | |
| 432 | Phosphorylation | KPKLDPTSYEAYQHQ CCCCCCCHHHHHHHH | 26.77 | 28889911 | |
| 443 | Ubiquitination | YQHQTQQKYLQEQQK HHHHHHHHHHHHHHH | 37.80 | 23749301 | |
| 450 | Ubiquitination | KYLQEQQKRQQQQKL HHHHHHHHHHHHHHH | 52.44 | 23749301 | |
| 456 | Ubiquitination | QKRQQQQKLQEQQLQ HHHHHHHHHHHHHHH | 48.04 | 23749301 | |
| 480 | Phosphorylation | QQQQLRATGQPPSQP HHHHHHHHCCCCCCC | 29.89 | 21126336 | |
| 485 | Phosphorylation | RATGQPPSQPQAQTQ HHHCCCCCCCCHHHH | 62.26 | 23749301 | |
| 491 | Phosphorylation | PSQPQAQTQSQQFGA CCCCCHHHHHHHHCC | 32.95 | 24909858 | |
| 493 | Phosphorylation | QPQAQTQSQQFGARY CCCHHHHHHHHCCCC | 29.36 | 21082442 | |
| 507 | Phosphorylation | YQPQQQPSAALRTPE CCCCCCCCCCCCCCC | 23.10 | 25704821 | |
| 512 | Phosphorylation | QPSAALRTPEQHPND CCCCCCCCCCCCCCC | 31.84 | 22890988 | |
| 522 | Phosphorylation | QHPNDDNSSLAASHK CCCCCCCCCHHHHHH | 33.45 | 17330950 | |
| 523 | Phosphorylation | HPNDDNSSLAASHKG CCCCCCCCHHHHHHH | 28.43 | 17330950 | |
| 527 | Phosphorylation | DNSSLAASHKGFFQK CCCCHHHHHHHHHHH | 21.81 | 17330950 | |
| 529 | Ubiquitination | SSLAASHKGFFQKLG CCHHHHHHHHHHHHC | 55.72 | 23749301 | |
| 537 | S-palmitoylation | GFFQKLGCC------ HHHHHHCCC------ | 3.45 | - | |
| 538 | S-palmitoylation | FFQKLGCC------- HHHHHCCC------- | 6.24 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KC11_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KC11_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KC11_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-63; SER-522 AND SER-523,AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522; SER-523 ANDSER-527, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-63, AND MASSSPECTROMETRY. | |
