DRS1_YEAST - dbPTM
DRS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DRS1_YEAST
UniProt AC P32892
Protein Name ATP-dependent RNA helicase DRS1
Gene Name DRS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 752
Subcellular Localization Nucleus, nucleolus .
Protein Description ATP-binding RNA helicase involved in ribosome assembly..
Protein Sequence MVVGTKKYSNLDFVPTISDSEDDVPILDSSDDEKVEAKKTTKKRKGKNNKKKVSEGDNLDEDVHEDLDAGFKFDLDADDTTSNFQGWNFLAEGESNKDDAEAFVKKDVDLDKIIRRKGGLVKMAHIDSKQEEETEKEKVEKENDSDDEELAMDGFGMGAPMNNGDENQSEEEEEEEEKEEEEEEEEEQEEMTLEKGGKDDEIDEEDDSEEAKADFYAPETEGDEAKKQMYENFNSLSLSRPVLKGLASLGYVKPSPIQSATIPIALLGKDIIAGAVTGSGKTAAFMIPIIERLLYKPAKIASTRVIVLLPTRELAIQVADVGKQIARFVSGITFGLAVGGLNLRQQEQMLKSRPDIVIATPGRFIDHIRNSASFNVDSVEILVMDEADRMLEEGFQDELNEIMGLLPSNRQNLLFSATMNSKIKSLVSLSLKKPVRIMIDPPKKAATKLTQEFVRIRKRDHLKPALLFNLIRKLDPTGQKRIVVFVARKETAHRLRIIMGLLGMSVGELHGSLTQEQRLDSVNKFKNLEVPVLICTDLASRGLDIPKIEVVINYDMPKSYEIYLHRVGRTARAGREGRSVTFVGESSQDRSIVRAAIKSVEENKSLTQGKALGRNVDWVQIEETNKLVESMNDTIEDILVEEKEEKEILRAEMQLRKGENMLKHKKEIQARPRRTWFQSESDKKNSKVLGALSRNKKVTNSKKRKREEAKADGNGARSYRKTKTDRIADQERTFKKQKSTNSNKKKGFKSRR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationSNLDFVPTISDSEDD
CCCCCCCCCCCCCCC		28.0128889911
18PhosphorylationLDFVPTISDSEDDVP
CCCCCCCCCCCCCCC		37.2521440633
20PhosphorylationFVPTISDSEDDVPIL
CCCCCCCCCCCCCCC		35.8128889911
29PhosphorylationDDVPILDSSDDEKVE
CCCCCCCCCCCHHHH		32.0221440633
30PhosphorylationDVPILDSSDDEKVEA
CCCCCCCCCCHHHHH		49.0721440633
112AcetylationKKDVDLDKIIRRKGG
HHCCCHHHHHHHCCC		47.5324489116
128PhosphorylationVKMAHIDSKQEEETE
EEEEECCHHHHHHHH		35.3228889911
208PhosphorylationEIDEEDDSEEAKADF
CCCCCCCCHHHHHHH		50.0525521595
299AcetylationRLLYKPAKIASTRVI
HHHCCCCHHCCCEEE		47.5424489116
302PhosphorylationYKPAKIASTRVIVLL
CCCCHHCCCEEEEEE		21.8827017623
432AcetylationSLVSLSLKKPVRIMI
HHHHCCCCCCEEEEE		52.2122865919
657AcetylationRAEMQLRKGENMLKH
HHHHHHHCCHHHHHH		78.2425381059
663AcetylationRKGENMLKHKKEIQA
HCCHHHHHHHHHHHC		42.4825381059
687AcetylationESDKKNSKVLGALSR
HHHHHCHHHHHHHHC		51.3722865919
693PhosphorylationSKVLGALSRNKKVTN
HHHHHHHHCCCCCCC		33.0230377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DRS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DRS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DRS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MED1_YEASTMED1genetic
19061648
RL33A_YEASTRPL33Agenetic
17548477
ERB1_YEASTERB1physical
25877921
DRS1_YEASTDRS1physical
25877921
RLP7_YEASTRLP7physical
25877921
DBP10_YEASTDBP10physical
25877921
LOC1_YEASTLOC1physical
25877921
NSA2_YEASTNSA2physical
25877921
EBP2_YEASTEBP2physical
25877921
MAK21_YEASTMAK21physical
25877921
NOP12_YEASTNOP12physical
25877921
NOP4_YEASTNOP4physical
25877921
TCPD_YEASTCCT4genetic
27708008
RTF1_YEASTRTF1genetic
27708008
INM1_YEASTINM1genetic
27708008
YCQ6_YEASTYCR016Wgenetic
27708008
MRM2_YEASTMRM2genetic
27708008
PSA3_YEASTPRE9genetic
27708008
SKN1_YEASTSKN1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
ACM1_YEASTACM1genetic
27708008
SRO7_YEASTSRO7genetic
27708008
MAK16_YEASTMAK16genetic
27708008
CDC24_YEASTCDC24genetic
27708008
SYIC_YEASTILS1genetic
27708008
MAK5_YEASTMAK5genetic
27708008
TECR_YEASTTSC13genetic
27708008
CDC48_YEASTCDC48genetic
27708008
CDC53_YEASTCDC53genetic
27708008
DNLI1_YEASTCDC9genetic
27708008
UBC3_YEASTCDC34genetic
27708008
MAK21_YEASTMAK21genetic
27708008
RRP1_YEASTRRP1genetic
27708008
TAF12_YEASTTAF12genetic
27708008
STT3_YEASTSTT3genetic
27708008
PESC_YEASTNOP7genetic
27708008
RPF1_YEASTRPF1genetic
27708008
MET30_YEASTMET30genetic
27708008
ARP4_YEASTARP4genetic
27708008
KTHY_YEASTCDC8genetic
27708008
MCM1_YEASTMCM1genetic
27708008
ERB1_YEASTERB1genetic
27708008
HAS1_YEASTHAS1genetic
27708008
RLP7_YEASTRLP7genetic
27708008
NOP2_YEASTNOP2genetic
27708008
YTM1_YEASTYTM1genetic
27708008
STU1_YEASTSTU1genetic
27708008
CDC37_YEASTCDC37genetic
27708008
NSE3_YEASTNSE3genetic
27708008
SLN1_YEASTSLN1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
MUM2_YEASTMUM2genetic
27708008
IML3_YEASTIML3genetic
27708008
SHG1_YEASTSHG1genetic
27708008
VPS41_YEASTVPS41genetic
27708008
AIM11_YEASTAIM11genetic
27708008
SGF73_YEASTSGF73genetic
27708008
VAM7_YEASTVAM7genetic
27708008
VMA21_YEASTVMA21genetic
27708008
CPD1_YEASTCPD1genetic
27708008
TNA1_YEASTTNA1genetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
SLT2_YEASTSLT2genetic
27708008
SSF1_YEASTSSF1genetic
27708008
HTD2_YEASTHTD2genetic
27708008
KC11_YEASTYCK1genetic
27708008
STB5_YEASTSTB5genetic
27708008
AIR1_YEASTAIR1genetic
27708008
SDS3_YEASTSDS3genetic
27708008
PEP8_YEASTPEP8genetic
27708008
BFA1_YEASTBFA1genetic
27708008
MCR1_YEASTMCR1genetic
27708008
ELF1_YEASTELF1genetic
27708008
EFM7_YEASTNNT1genetic
27708008
CSI1_YEASTCSI1genetic
27708008
PET8_YEASTPET8genetic
27708008
NOP12_YEASTNOP12genetic
27708008
HAT1_YEASTHAT1genetic
27708008
FMP40_YEASTFMP40genetic
27708008
YP245_YEASTYPL245Wgenetic
27708008
YP089_YEASTYPR089Wgenetic
27708008
VPS8_YEASTVPS8genetic
27708008
H3_YEASTHHT1genetic
27708008
SEC66_YEASTSEC66genetic
27708008
AIM4_YEASTAIM4genetic
27708008
CS111_YEASTCOS111genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
RKM2_YEASTRKM2genetic
27708008
VPS74_YEASTVPS74genetic
27708008
PIB2_YEASTPIB2genetic
27708008
DBP3_YEASTDBP3genetic
27708008
RTG2_YEASTRTG2genetic
27708008
G3P3_YEASTTDH3genetic
27708008
GPP1_YEASTGPP1genetic
27708008
SNX4_YEASTSNX4genetic
27708008
MNN11_YEASTMNN11genetic
27708008
HOC1_YEASTHOC1genetic
27708008
UBL1_YEASTYUH1genetic
27708008
ILM1_YEASTILM1genetic
27708008
SFK1_YEASTSFK1genetic
27708008
TCTP_YEASTTMA19genetic
27708008
CYT2_YEASTCYT2genetic
27708008
AVT3_YEASTAVT3genetic
27708008
ASH1_YEASTASH1genetic
27708008
DBP7_YEASTDBP7genetic
27708008
COX8_YEASTCOX8genetic
27708008
SST2_YEASTSST2genetic
27708008
PPZ1_YEASTPPZ1genetic
27708008
SUB1_YEASTSUB1genetic
27708008
YET2_YEASTYET2genetic
27708008
IPA3_YEASTPAI3genetic
27708008
TMA23_YEASTTMA23genetic
27708008
SCS7_YEASTSCS7genetic
27708008
DOM34_YEASTDOM34genetic
27708008
HRB1_YEASTHRB1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
REXO4_YEASTREX4genetic
27708008
YO098_YEASTYOL098Cgenetic
27708008
PUR6_YEASTADE2genetic
27708008
MTHR1_YEASTMET12genetic
27708008
SUR1_YEASTSUR1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
KES1_YEASTKES1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
NEW1_YEASTNEW1genetic
27708008
NOP4_YEASTNOP4physical
27077951
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DRS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208, AND MASSSPECTROMETRY.

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