CS111_YEAST - dbPTM
CS111_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CS111_YEAST
UniProt AC P38308
Protein Name F-box protein COS111
Gene Name COS111
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 924
Subcellular Localization
Protein Description F-box protein probably involved in ubiquitin conjugation pathway. Involved in the resistance to ciclopirox olamine (CPO), a synthetic antifungal agent..
Protein Sequence MSSASRLQNVNIVSNNYSRYGTSVYDKLYHSNGSGSNNAGKNSTTVGKLSSISQKSRSKQRHGSNCSRSMSQSPLSTFKSPLSNQNQSSAPDDLASIGQRRSDDVTSLDNETIITMNSRKSRIKKKYKSLISTSSKKFMNKLYDHGASSDSFSIFSLKTSHSGKHENSRFEKLRKRKYHAWGKFADINDLPVEIIAKILSEFELGRDQKTLVRCLYVSKKFYKATKIVLYRLPYFTSTYRVAQFVTSLRLHPDNGAYVKVLDLSHLKPGIIGQDSKDSQGLDDDGHSRRHRRRRRRSTNTSLNLPPATPTSTISNEDDANSGLIKDDASNGSEVEDLALAGWRDWRYRNEPLYSSPLLNSFKLKKVVSRSSSITSTSSGNSTGVHSTRRQRSNSSVASITTSIMSSIYNTSHVSLSSTTSNTSNGNISSGSNLSRVSTAGSLKKASAKSTRSSPQKAKPISDITSSSWFRMRLSSRNRKARTANTINLKNSKDKSDDDFKVLKHDSGHPSNYRSSTLKFSIEQPFSTHHPYANKFLLKYAPYKDLPLGYILHMLNLCPNLVELNLSNLVICTDFKLINQRSERRRMTSSLLPAVQESSVSAGPEKDLEIVYMTDSGKGYEYYEGLSKKHSRSSSLGTNPSSWIGGQANWTDYPPPIDAQTKTREEHRRNNTLNNKNVVLKKLNPFEIFEMICNRNEEKGGYCSLTKVKMNDIVWCRQYMVKYFVMRTFRQHLDYKSMENNSYERHLFSFRDSGLDRNFSWACNAKLHEFVALMVMDHLSNLDDLGLEELFNIKSEKLYIKNYCCRDPDILEISNLFDIRYGAGSEADATSDSNLEAESLQFRLTILKTEKPTSFWLTKVSKDYVSLVVKLCVDDDIDMDKMKVGKPTLRIDSITHNLISRLKELRRVDLRRNVGENNYYAESII
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationTSVYDKLYHSNGSGS
CCHHHCHHCCCCCCC		14.6722890988
31PhosphorylationVYDKLYHSNGSGSNN
HHHCHHCCCCCCCCC		29.3622890988
34PhosphorylationKLYHSNGSGSNNAGK
CHHCCCCCCCCCCCC		43.2122890988
36PhosphorylationYHSNGSGSNNAGKNS
HCCCCCCCCCCCCCC		28.7122890988
43PhosphorylationSNNAGKNSTTVGKLS
CCCCCCCCCCHHHHH		29.0122890988
44PhosphorylationNNAGKNSTTVGKLSS
CCCCCCCCCHHHHHH		34.5922890988
45PhosphorylationNAGKNSTTVGKLSSI
CCCCCCCCHHHHHHH		27.3822890988
50PhosphorylationSTTVGKLSSISQKSR
CCCHHHHHHHCHHHH		29.1622890988
51PhosphorylationTTVGKLSSISQKSRS
CCHHHHHHHCHHHHH		36.3722890988
53PhosphorylationVGKLSSISQKSRSKQ
HHHHHHHCHHHHHHH		33.2422890988
69PhosphorylationHGSNCSRSMSQSPLS
CCCCCCHHHCCCCHH		13.3921551504
73PhosphorylationCSRSMSQSPLSTFKS
CCHHHCCCCHHHCCC		22.0921551504
127PhosphorylationKSRIKKKYKSLISTS
HHHHHHHHHHHHHHC		18.0627017623
143PhosphorylationKKFMNKLYDHGASSD
HHHHHHHHHCCCCCC		13.9128889911
148PhosphorylationKLYDHGASSDSFSIF
HHHHCCCCCCCEEEE		38.9928889911
149PhosphorylationLYDHGASSDSFSIFS
HHHCCCCCCCEEEEE		36.4228889911
151PhosphorylationDHGASSDSFSIFSLK
HCCCCCCCEEEEEEC		23.8828889911
259UbiquitinationPDNGAYVKVLDLSHL
CCCCCEEEEEEHHHC		25.1417644757
267UbiquitinationVLDLSHLKPGIIGQD
EEEHHHCCCCCCCCC		35.4617644757
276UbiquitinationGIIGQDSKDSQGLDD
CCCCCCCCCCCCCCC		70.4617644757
362UbiquitinationSPLLNSFKLKKVVSR
CCCHHHHEEEEEEEC		60.2517644757
438PhosphorylationSNLSRVSTAGSLKKA
CCCCCEECCCHHHHH		31.9827214570
441PhosphorylationSRVSTAGSLKKASAK
CCEECCCHHHHHCCC		34.2527214570
458UbiquitinationRSSPQKAKPISDITS
CCCCCCCCCHHHCCC		50.3323749301
503UbiquitinationDDDFKVLKHDSGHPS
CCCCEEEECCCCCCC		48.6417644757
588PhosphorylationSERRRMTSSLLPAVQ
HHHHHHHHHHHHHHH		15.0528889911
589PhosphorylationERRRMTSSLLPAVQE
HHHHHHHHHHHHHHH		25.4328889911
634PhosphorylationKKHSRSSSLGTNPSS
CCCCCCCCCCCCCHH		31.8727017623
640PhosphorylationSSLGTNPSSWIGGQA
CCCCCCCHHHCCCCC		40.1327017623
662PhosphorylationPIDAQTKTREEHRRN
CCCCCCCCHHHHHHH		46.8527017623
844PhosphorylationESLQFRLTILKTEKP
HEEEEEEEEEECCCC		21.7322890988
848PhosphorylationFRLTILKTEKPTSFW
EEEEEEECCCCCCEE		45.8822890988
852PhosphorylationILKTEKPTSFWLTKV
EEECCCCCCEEEEEC		47.8522890988
853PhosphorylationLKTEKPTSFWLTKVS
EECCCCCCEEEEECC		23.9722890988
857PhosphorylationKPTSFWLTKVSKDYV
CCCCEEEEECCHHHH		21.7222890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CS111_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CS111_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CS111_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SKP1_YEASTSKP1physical
11805837
NAP1_YEASTNAP1physical
11805837
PEX19_YEASTPEX19genetic
27708008
PUF6_YEASTPUF6genetic
27708008
TFS2_YEASTDST1genetic
27708008
HSE1_YEASTHSE1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
XDJ1_YEASTXDJ1genetic
27708008
TMA23_YEASTTMA23genetic
27708008
SIW14_YEASTSIW14genetic
27708008
RL9B_YEASTRPL9Bgenetic
27708008
RTG1_YEASTRTG1genetic
27708008
POC4_YEASTPOC4genetic
27708008
PPAL_YEASTLTP1genetic
27708008
YBQ6_YEASTYBR056Wgenetic
27708008
UBX3_YEASTUBX3genetic
27708008
BMH1_YEASTBMH1genetic
27708008
RIM15_YEASTRIM15genetic
27708008
RL29_YEASTRPL29genetic
27708008
PALF_YEASTRIM8genetic
27708008
AAKG_YEASTSNF4genetic
27708008
ATG1_YEASTATG1genetic
27708008
FKS2_YEASTGSC2genetic
27708008
PHB2_YEASTPHB2genetic
27708008
SSBP1_YEASTSBP1genetic
27708008
ERC1_YEASTERC1genetic
27708008
UIP5_YEASTUIP5genetic
27708008
ATG10_YEASTATG10genetic
27708008
VBA1_YEASTVBA1genetic
27708008
RAS2_YEASTRAS2genetic
27708008
DMA2_YEASTDMA2genetic
27708008
LSM7_YEASTLSM7genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
VAM10_YEASTVAM10genetic
27708008
MRX11_YEASTYPL041Cgenetic
27708008
HSP7F_YEASTSSE1genetic
27708008
RGC1_YEASTRGC1genetic
27708008
EMI1_YEASTEMI1genetic
29674565
COG3_YEASTCOG3genetic
29674565
LRP1_YEASTLRP1genetic
29674565
ERG2_YEASTERG2genetic
29674565
ATPN_YEASTATP20genetic
29674565
MDM10_YEASTMDM10genetic
29674565
VAC14_YEASTVAC14genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CS111_YEAST

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Related Literatures of Post-Translational Modification

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