SIW14_YEAST - dbPTM
SIW14_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SIW14_YEAST
UniProt AC P53965
Protein Name Tyrosine-protein phosphatase SIW14
Gene Name SIW14
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 281
Subcellular Localization Cytoplasm .
Protein Description Plays a role in actin filament organization and endocytosis..
Protein Sequence MGLYQAKNDEGSDPKSSSKIDDLIENEAEIIRLIKEDGKLLIDNGDGRDIHNIIQEDKLLSVEFNEVLKRFHGEEKSDIPRKEFDEDEDDGYDSNEHHQKTIEVMNTLNHVINKEVIPPENFSHVVGEIYRSSFPRQENFSFLHERLKLKSILVLIPEEYPQENLNFLKLTGIKLYQVGMSGNKEPFVNIPSHLLTKALEIVLNPANQPILIHCNRGKHRTGCLIGCIRKLQNWSLTMIFDEYRRFAFPKARALDQQFIEMYDDDEIKRIASKNNWLPLQW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationDEGSDPKSSSKIDDL
CCCCCCCCCCCHHHH		45.2722369663
17PhosphorylationEGSDPKSSSKIDDLI
CCCCCCCCCCHHHHH		41.6022369663
18PhosphorylationGSDPKSSSKIDDLIE
CCCCCCCCCHHHHHH		40.5022369663
77PhosphorylationRFHGEEKSDIPRKEF
HHCCCCCCCCCHHHC		44.0119823750
92PhosphorylationDEDEDDGYDSNEHHQ
CCCCCCCCCCCHHHH		24.1622890988
94PhosphorylationDEDDGYDSNEHHQKT
CCCCCCCCCHHHHHH		35.3225521595
171PhosphorylationNLNFLKLTGIKLYQV
HCCHHHHHCCEEEEE		34.9619823750
176PhosphorylationKLTGIKLYQVGMSGN
HHHCCEEEEECCCCC		8.9919823750
181PhosphorylationKLYQVGMSGNKEPFV
EEEEECCCCCCCCCC		33.0319823750
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SIW14_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SIW14_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SIW14_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EMI2_YEASTEMI2physical
11805837
HXT6_YEASTHXT6physical
11805837
CORO_YEASTCRN1physical
16554755
OCA1_YEASTOCA1physical
16429126
OCA4_YEASTOCA4physical
16429126
OCA5_YEASTOCA5physical
16429126
NPR1_YEASTNPR1genetic
18166280
GLN3_YEASTGLN3genetic
18166280
SSB1_YEASTSSB1physical
19536198
SLT2_YEASTSLT2genetic
15020461
OCA5_YEASTOCA5genetic
19176519
GCN2_YEASTGCN2genetic
19176519
YPT31_YEASTYPT31genetic
20526336
TPM1_YEASTTPM1genetic
20526336
SUR1_YEASTSUR1genetic
20526336
VPS41_YEASTVPS41genetic
20526336
VPS17_YEASTVPS17genetic
20526336
THRC_YEASTTHR4genetic
20526336
MET18_YEASTMET18genetic
21127252
VMS1_YEASTVMS1genetic
21127252
INO2_YEASTINO2genetic
21127252
2AAA_YEASTTPD3genetic
25313402
PP2A2_YEASTPPH22genetic
25313402
PP2A1_YEASTPPH21genetic
25313402
PP11_YEASTSIT4genetic
25313402
DDP1_YEASTDDP1genetic
26828065
VIP1_YEASTVIP1genetic
26828065
PALF_YEASTRIM8genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
GGPPS_YEASTBTS1genetic
27708008
THRC_YEASTTHR4genetic
27708008
CSM1_YEASTCSM1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
SWF1_YEASTSWF1genetic
27708008
ARO1_YEASTARO1genetic
27708008
NUM1_YEASTNUM1genetic
27708008
DHAS_YEASTHOM2genetic
27708008
SAC3_YEASTSAC3genetic
27708008
ESC2_YEASTESC2genetic
27708008
SA155_YEASTSAP155genetic
27708008
MON1_YEASTMON1genetic
27708008
ATC1_YEASTPMR1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
VMA21_YEASTVMA21genetic
27708008
HTD2_YEASTHTD2genetic
27708008
STB5_YEASTSTB5genetic
27708008
FLX1_YEASTFLX1genetic
27708008
RPE_YEASTRPE1genetic
27708008
ILM1_YEASTILM1genetic
27708008
LDB18_YEASTLDB18genetic
27708008
VAC14_YEASTVAC14genetic
27708008
SST2_YEASTSST2genetic
27708008
MSC1_YEASTMSC1genetic
27708008
GAS1_YEASTGAS1genetic
27708008
SIN3_YEASTSIN3genetic
27708008
KPR5_YEASTPRS5genetic
27708008
NIP80_YEASTNIP100genetic
27708008
TKT1_YEASTTKL1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SIW14_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, AND MASSSPECTROMETRY.

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