2AAA_YEAST - dbPTM
2AAA_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID 2AAA_YEAST
UniProt AC P31383
Protein Name Protein phosphatase PP2A regulatory subunit A
Gene Name TPD3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 635
Subcellular Localization
Protein Description Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates..
Protein Sequence MSGARSTTAGAVPSAATTSTTSTTSNSKDSDSNESLYPLALLMDELKHDDIANRVEAMKKLDTIALALGPERTRNELIPFLTEVAQDDEDEVFAVLAEQLGKFVPYIGGPQYATILLPVLEILASAEETLVREKAVDSLNNVAQELSQEQLFSDFVPLIEHLATADWFSSKVSACGLFKSVIVRIKDDSLRKNILALYLQLAQDDTPMVKRAVGKNLPILIDLLTQNLGLSTDEDWDYISNIFQKIINDNQDSVKFLAVDCLISILKFFNAKGDESHTQDLLNSAVKLIGDEAWRVRYMAADRFSDLASQFSSNQAYIDELVQPFLNLCEDNEGDVREAVAKQVSGFAKFLNDPSIILNKILPAVQNLSMDESETVRSALASKITNIVLLLNKDQVINNFLPILLNMLRDEFPDVRLNIIASLKVVNDVIGIELLSDSLLPAITELAKDVNWRVRMAIIEYIPILAEQLGMQFFDQQLSDLCLSWLWDTVYSIREAAVNNLKRLTEIFGSDWCRDEIISRLLKFDLQLLENFVSRFTILSALTTLVPVVSLDVVTEQLLPFISHLADDGVPNIRFNVAKSYAVIVKVLIKDEAKYDALIKNTILPSLQTLCQDEDVDVKYFAKKSLAECQELLKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSGARSTTA
------CCCCCCCCC		40.9519823750
6Phosphorylation--MSGARSTTAGAVP
--CCCCCCCCCCCCC		29.5822369663
7Phosphorylation-MSGARSTTAGAVPS
-CCCCCCCCCCCCCC		18.3422369663
8PhosphorylationMSGARSTTAGAVPSA
CCCCCCCCCCCCCCC		25.0822369663
14PhosphorylationTTAGAVPSAATTSTT
CCCCCCCCCCCCCCC		24.7622369663
17PhosphorylationGAVPSAATTSTTSTT
CCCCCCCCCCCCCCC		22.4622369663
18PhosphorylationAVPSAATTSTTSTTS
CCCCCCCCCCCCCCC		21.2522369663
19PhosphorylationVPSAATTSTTSTTSN
CCCCCCCCCCCCCCC		25.9022369663
20PhosphorylationPSAATTSTTSTTSNS
CCCCCCCCCCCCCCC		23.7522369663
21PhosphorylationSAATTSTTSTTSNSK
CCCCCCCCCCCCCCC		24.6822369663
22PhosphorylationAATTSTTSTTSNSKD
CCCCCCCCCCCCCCC		29.7622369663
23PhosphorylationATTSTTSTTSNSKDS
CCCCCCCCCCCCCCC		31.9522369663
24PhosphorylationTTSTTSTTSNSKDSD
CCCCCCCCCCCCCCC		26.1922369663
25PhosphorylationTSTTSTTSNSKDSDS
CCCCCCCCCCCCCCC		38.9122369663
27PhosphorylationTTSTTSNSKDSDSNE
CCCCCCCCCCCCCCC		37.2922369663
253PhosphorylationIINDNQDSVKFLAVD
HHCCCCCHHHHHHHH		19.9030377154
342UbiquitinationDVREAVAKQVSGFAK
HHHHHHHHHHHHHHH		44.6323749301
345PhosphorylationEAVAKQVSGFAKFLN
HHHHHHHHHHHHHHC		26.2127017623
349AcetylationKQVSGFAKFLNDPSI
HHHHHHHHHHCCHHH		48.3924489116
594AcetylationVLIKDEAKYDALIKN
EECCCHHHHHHHHHC		41.4324489116
634UbiquitinationAECQELLKN------
HHHHHHHHC------		73.5523749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of 2AAA_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of 2AAA_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of 2AAA_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
2ABA_YEASTCDC55physical
11805826
2A5D_YEASTRTS1physical
11805826
KEL1_YEASTKEL1physical
11805826
LTE1_YEASTLTE1physical
11805826
PP2A1_YEASTPPH21physical
11805826
PP2A2_YEASTPPH22physical
11805826
PTPA2_YEASTRRD2physical
11805826
RTS3_YEASTRTS3physical
11805826
YOR1_YEASTYOR1physical
11805826
ZDS1_YEASTZDS1physical
11805826
ZDS2_YEASTZDS2physical
11805826
PP2A1_YEASTPPH21physical
10329624
PP2A2_YEASTPPH22physical
10329624
PP2A1_YEASTPPH21physical
14551259
2ABA_YEASTCDC55physical
10329624
PTPA1_YEASTRRD1physical
15689491
PTPA2_YEASTRRD2physical
15689491
PP2A1_YEASTPPH21physical
16554755
PP2A2_YEASTPPH22physical
16554755
2ABA_YEASTCDC55physical
16554755
RTS3_YEASTRTS3physical
16554755
ZDS2_YEASTZDS2physical
16554755
ZDS1_YEASTZDS1physical
16554755
SSB2_YEASTSSB2physical
16554755
2A5D_YEASTRTS1physical
16554755
PTPA2_YEASTRRD2physical
16554755
2ABA_YEASTCDC55physical
16429126
PP2A2_YEASTPPH22physical
16429126
RS17A_YEASTRPS17Aphysical
16429126
RS3A2_YEASTRPS1Bphysical
16429126
RS24A_YEASTRPS24Bphysical
16429126
RS24B_YEASTRPS24Bphysical
16429126
2A5D_YEASTRTS1physical
16429126
RTS3_YEASTRTS3physical
16429126
YOR1_YEASTYOR1physical
16429126
ZDS1_YEASTZDS1physical
16429126
ZDS2_YEASTZDS2physical
16429126
KEL1_YEASTKEL1physical
16429126
LTE1_YEASTLTE1physical
16429126
PP2A1_YEASTPPH21physical
16429126
PTPA1_YEASTRRD1genetic
17550305
PTPA2_YEASTRRD2genetic
17550305
PPME1_YEASTPPE1genetic
17550305
ARF3_YEASTARF3physical
18467557
VATC_YEASTVMA5physical
18467557
TGL5_YEASTTGL5physical
18467557
PGM2_YEASTPGM2physical
18467557
FAR11_YEASTFAR11physical
18719252
2A5D_YEASTRTS1physical
21690308
FAR11_YEASTFAR11physical
22298706
CG12_YEASTCLN2physical
23518505
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of 2AAA_YEAST

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Related Literatures of Post-Translational Modification

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