| UniProt ID | LTE1_YEAST | |
|---|---|---|
| UniProt AC | P07866 | |
| Protein Name | Guanine nucleotide exchange factor LTE1 | |
| Gene Name | LTE1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1435 | |
| Subcellular Localization | Cytoplasm. Bud. The localization to the bud requires interaction with KEL1, as well as the presence of septins, CDC42, CLA4 and RAS2. | |
| Protein Description | GDP-GTP exchange factor for TEM1, a Ras-like protein, component of the mitotic exit network (MEN). Activation of TEM1 by LTE1 in the bud ultimately leads to activation of CDC15 followed by the release of CDC14 from the nucleolus, which then inactivates cyclin-dependent kinases (CDKs) activity by several mechanism. Required for TEM1 localization to the bud cortex during mitotic exit. Fine-tunes the timing of the mitotic exit and couples this event with cytokinesis.; Involved in proprotein-processing like proalpha factor-processing in the secretory pathway.. | |
| Protein Sequence | MEIFSQKDYYPTPSSNVISYESDCVSKPVNSADLPALIVHLSSPLEGVDYNASADFFLIYRNFITPQDLHDLLIYRFRWCIREITTNAAKAKRRRIGEVALVRTFVLLRHSILNYFVQDFLPNITLRLRLIEFLNDKHIEQYPKIISSCIINLKKNWVHCSKLVWENIELNEPDKLDFDAWLHYSLKDFTQLESLHKRGSRLSIYARQSFASPDFRNQSVLSLYKTSDVFRLPEKLQSSNSSKNQRSPSMLLFPDNTSNVYSKHRIAKEPSVDNESEDMSDSKQKISHLSKVTLVSTLMKGVDYPSSYAVDKIMPPTPAKKVEFILNSLYIPEDLNEQSGTLQGTSTTSSLDNNSNSNSRSNTSSMSVLHRSAIGLLAKWMKNHNRHDSSNDKKFMSAIKPANQKPEMDAFVKYVVSISSLNRKSSKEEEEEFLNSDSSKFDILSARTIDEVESLLHLQNQLIEKVQTHSNNNRGPTVNVDCERREHIHDIKILQQNSFKPSNDNFSAMDNLDLYQTVSSIAQSVISLTNTLNKQLQNNESNMQPSPSYDALQRRKVKSLTTAYYNKMHGSYSAESMRLFDKDNSSSRTDENGPQRLLFHETDKTNSEAITNMTPRRKNHSQSQKSMTSSPLKNVLPDLKESSPLNDSREDTESITYSYDSELSSSSPPRDTVTKKSRKVRNIVNNTDSPTLKTKTGFLNLREFTFEDTKSLDEKKSTIDGLEKNYDNKENQESEYESTKKLDNSLDASSEANNYDITTRKKHSSCNHKIKQAVVRPASGRISISRVQSIAITPTKELSIVDPEQNKSNSVIEEISEIEPLNLEYNKKSALYSDTSSTVISISTSKLFESAQNSPLKQTQNPQREFPNGTSVSETNRIRLSIAPTIESVVSDLNSITTGSTVETFETSRDLPVPHQRIINLREEYQRGNQDIISNTSSLHELKTIDLSDSNNDLESPSTHAKNNKYFFSPDDGSIDVASPMKNVEELKSKFLKNESETNSNISGSVLTMDDIDINDTSSARNTRRANSESAFTGSLNKKNLNEIANMLDDSINDDPITVALMKLEGTYEKIPEKPENTKSSDAIGIKTSKLADEVEMLNLNNLPSFQNSPAEKRKSLLIERRRQTIMNIPFTPDQSEKEGFTSSSPEKIDVSANVDVAVQAAQIQELIGQYRIHDSRLMISNNESHVPFILMYDSLSVAQQMTLIEKEILGEIDWKDLLDLKMKHEGPQVISWLQLLVRNETLSGIDLAISRFNLTVDWIISEILLTKSSKMKRNVIQRFIHVADHCRTFQNFNTLMEIILALSSSVVQKFTDAWRLIEPGDLLTWEELKKIPSLDRNYSTIRNLLNSVNPLVGCVPFIVVYLSDLSANAEKKDWILEDKVVNYNKFDTNVQIVKNFIQRVQWSKFYTFKVNHELLSKCVYISTLTQEEINELST | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 200 | Phosphorylation | ESLHKRGSRLSIYAR HHHHHHCCCEEEEEE | 33.80 | 28889911 | |
| 203 | Phosphorylation | HKRGSRLSIYARQSF HHHCCCEEEEEECCC | 16.67 | 21440633 | |
| 209 | Phosphorylation | LSIYARQSFASPDFR EEEEEECCCCCCCCC | 19.75 | 25752575 | |
| 212 | Phosphorylation | YARQSFASPDFRNQS EEECCCCCCCCCCCH | 24.00 | 25752575 | |
| 219 | Phosphorylation | SPDFRNQSVLSLYKT CCCCCCCHHHHHHHH | 28.68 | 22369663 | |
| 222 | Phosphorylation | FRNQSVLSLYKTSDV CCCCHHHHHHHHCCH | 27.74 | 22369663 | |
| 224 | Phosphorylation | NQSVLSLYKTSDVFR CCHHHHHHHHCCHHC | 14.62 | 28889911 | |
| 247 | Phosphorylation | NSSKNQRSPSMLLFP CCCCCCCCCCEEECC | 16.15 | 19823750 | |
| 249 | Phosphorylation | SKNQRSPSMLLFPDN CCCCCCCCEEECCCC | 24.25 | 25521595 | |
| 257 | Phosphorylation | MLLFPDNTSNVYSKH EEECCCCCCCCCCCC | 29.11 | 25521595 | |
| 268 | Ubiquitination | YSKHRIAKEPSVDNE CCCCCCCCCCCCCCC | 68.72 | 23749301 | |
| 271 | Phosphorylation | HRIAKEPSVDNESED CCCCCCCCCCCCCCC | 43.10 | 23749301 | |
| 276 | Phosphorylation | EPSVDNESEDMSDSK CCCCCCCCCCCCCHH | 45.19 | 23749301 | |
| 280 | Phosphorylation | DNESEDMSDSKQKIS CCCCCCCCCHHHHHH | 51.56 | 28889911 | |
| 290 | Phosphorylation | KQKISHLSKVTLVST HHHHHHHHHHHHHHH | 21.47 | 21440633 | |
| 293 | Phosphorylation | ISHLSKVTLVSTLMK HHHHHHHHHHHHHHC | 25.77 | 21440633 | |
| 296 | Phosphorylation | LSKVTLVSTLMKGVD HHHHHHHHHHHCCCC | 20.95 | 28152593 | |
| 297 | Phosphorylation | SKVTLVSTLMKGVDY HHHHHHHHHHCCCCC | 24.32 | 21440633 | |
| 306 | Phosphorylation | MKGVDYPSSYAVDKI HCCCCCCCCCCCCCC | 29.74 | 28889911 | |
| 307 | Phosphorylation | KGVDYPSSYAVDKIM CCCCCCCCCCCCCCC | 16.77 | 21440633 | |
| 308 | Phosphorylation | GVDYPSSYAVDKIMP CCCCCCCCCCCCCCC | 18.25 | 28889911 | |
| 317 | Phosphorylation | VDKIMPPTPAKKVEF CCCCCCCCCHHHHHH | 29.97 | 28152593 | |
| 361 | Phosphorylation | NSNSNSRSNTSSMSV CCCCCCCCCCCHHHH | 44.26 | 19779198 | |
| 363 | Phosphorylation | NSNSRSNTSSMSVLH CCCCCCCCCHHHHHH | 24.35 | 19779198 | |
| 364 | Phosphorylation | SNSRSNTSSMSVLHR CCCCCCCCHHHHHHH | 28.44 | 19779198 | |
| 365 | Phosphorylation | NSRSNTSSMSVLHRS CCCCCCCHHHHHHHH | 17.03 | 19779198 | |
| 372 | Phosphorylation | SMSVLHRSAIGLLAK HHHHHHHHHHHHHHH | 17.31 | 25752575 | |
| 417 | Phosphorylation | AFVKYVVSISSLNRK HHHHHHHHHHHHCCC | 13.50 | 21440633 | |
| 419 | Phosphorylation | VKYVVSISSLNRKSS HHHHHHHHHHCCCCC | 22.67 | 21440633 | |
| 420 | Phosphorylation | KYVVSISSLNRKSSK HHHHHHHHHCCCCCH | 28.17 | 21551504 | |
| 425 | Phosphorylation | ISSLNRKSSKEEEEE HHHHCCCCCHHHHHH | 43.32 | 30377154 | |
| 426 | Phosphorylation | SSLNRKSSKEEEEEF HHHCCCCCHHHHHHH | 47.31 | 30377154 | |
| 427 | Ubiquitination | SLNRKSSKEEEEEFL HHCCCCCHHHHHHHH | 76.00 | 23749301 | |
| 527 | Phosphorylation | SIAQSVISLTNTLNK HHHHHHHHHHHHHHH | 27.30 | 28889911 | |
| 541 | Phosphorylation | KQLQNNESNMQPSPS HHHHCCCCCCCCCCC | 39.46 | 21440633 | |
| 546 | Phosphorylation | NESNMQPSPSYDALQ CCCCCCCCCCHHHHH | 15.02 | 25752575 | |
| 548 | Phosphorylation | SNMQPSPSYDALQRR CCCCCCCCHHHHHHH | 39.73 | 21440633 | |
| 549 | Phosphorylation | NMQPSPSYDALQRRK CCCCCCCHHHHHHHH | 14.49 | 25752575 | |
| 559 | Phosphorylation | LQRRKVKSLTTAYYN HHHHHHHHHHHHHHH | 33.66 | 21440633 | |
| 561 | Phosphorylation | RRKVKSLTTAYYNKM HHHHHHHHHHHHHHH | 19.23 | 24961812 | |
| 562 | Phosphorylation | RKVKSLTTAYYNKMH HHHHHHHHHHHHHHC | 20.25 | 24961812 | |
| 564 | Phosphorylation | VKSLTTAYYNKMHGS HHHHHHHHHHHHCCC | 12.89 | 19779198 | |
| 565 | Phosphorylation | KSLTTAYYNKMHGSY HHHHHHHHHHHCCCC | 13.07 | 19779198 | |
| 571 | Phosphorylation | YYNKMHGSYSAESMR HHHHHCCCCCHHHHC | 10.96 | 22369663 | |
| 572 | Phosphorylation | YNKMHGSYSAESMRL HHHHCCCCCHHHHCC | 19.25 | 22369663 | |
| 573 | Phosphorylation | NKMHGSYSAESMRLF HHHCCCCCHHHHCCC | 27.53 | 22369663 | |
| 576 | Phosphorylation | HGSYSAESMRLFDKD CCCCCHHHHCCCCCC | 14.66 | 21440633 | |
| 585 | Phosphorylation | RLFDKDNSSSRTDEN CCCCCCCCCCCCCCC | 39.56 | 21440633 | |
| 586 | Phosphorylation | LFDKDNSSSRTDENG CCCCCCCCCCCCCCC | 30.05 | 19779198 | |
| 587 | Phosphorylation | FDKDNSSSRTDENGP CCCCCCCCCCCCCCC | 38.73 | 19779198 | |
| 589 | Phosphorylation | KDNSSSRTDENGPQR CCCCCCCCCCCCCCC | 50.00 | 27017623 | |
| 611 | Phosphorylation | KTNSEAITNMTPRRK CCCCHHHHHCCCCCC | 26.45 | 22369663 | |
| 614 | Phosphorylation | SEAITNMTPRRKNHS CHHHHHCCCCCCCCC | 18.73 | 22369663 | |
| 623 | Phosphorylation | RRKNHSQSQKSMTSS CCCCCCHHHHCCCCC | 42.46 | 27017623 | |
| 626 | Phosphorylation | NHSQSQKSMTSSPLK CCCHHHHCCCCCHHH | 21.47 | 28889911 | |
| 628 | Phosphorylation | SQSQKSMTSSPLKNV CHHHHCCCCCHHHHH | 32.89 | 22369663 | |
| 629 | Phosphorylation | QSQKSMTSSPLKNVL HHHHCCCCCHHHHHC | 22.71 | 22369663 | |
| 630 | Phosphorylation | SQKSMTSSPLKNVLP HHHCCCCCHHHHHCC | 25.70 | 22369663 | |
| 643 | Phosphorylation | LPDLKESSPLNDSRE CCCHHHCCCCCCCCC | 34.20 | 28889911 | |
| 648 | Phosphorylation | ESSPLNDSREDTESI HCCCCCCCCCHHCCE | 36.17 | 27017623 | |
| 656 | Phosphorylation | REDTESITYSYDSEL CCHHCCEEEEECCCC | 18.72 | 21551504 | |
| 657 | Phosphorylation | EDTESITYSYDSELS CHHCCEEEEECCCCC | 11.99 | 21551504 | |
| 667 | Phosphorylation | DSELSSSSPPRDTVT CCCCCCCCCCCCCCC | 40.65 | 21551504 | |
| 672 | Phosphorylation | SSSPPRDTVTKKSRK CCCCCCCCCCCHHHH | 31.21 | 21551504 | |
| 687 | Phosphorylation | VRNIVNNTDSPTLKT HHHHHCCCCCCCCCC | 32.42 | 22369663 | |
| 689 | Phosphorylation | NIVNNTDSPTLKTKT HHHCCCCCCCCCCCC | 20.11 | 22369663 | |
| 691 | Phosphorylation | VNNTDSPTLKTKTGF HCCCCCCCCCCCCCE | 44.85 | 25521595 | |
| 705 | Phosphorylation | FLNLREFTFEDTKSL EEEEEEEEHHCCCCH | 22.74 | 30377154 | |
| 709 | Phosphorylation | REFTFEDTKSLDEKK EEEEHHCCCCHHHHH | 18.48 | 28889911 | |
| 711 | Phosphorylation | FTFEDTKSLDEKKST EEHHCCCCHHHHHHH | 43.05 | 23749301 | |
| 729 | Ubiquitination | LEKNYDNKENQESEY HHHHCCCCCCCHHHH | 55.96 | 23749301 | |
| 734 | Phosphorylation | DNKENQESEYESTKK CCCCCCHHHHHHHHH | 35.40 | 28889911 | |
| 738 | Phosphorylation | NQESEYESTKKLDNS CCHHHHHHHHHHHHC | 44.62 | 28889911 | |
| 741 | Ubiquitination | SEYESTKKLDNSLDA HHHHHHHHHHHCCCC | 62.25 | 23749301 | |
| 745 | Phosphorylation | STKKLDNSLDASSEA HHHHHHHCCCCCHHH | 27.56 | 21440633 | |
| 749 | Phosphorylation | LDNSLDASSEANNYD HHHCCCCCHHHCCCC | 28.51 | 24961812 | |
| 750 | Phosphorylation | DNSLDASSEANNYDI HHCCCCCHHHCCCCC | 42.31 | 23749301 | |
| 758 | Phosphorylation | EANNYDITTRKKHSS HHCCCCCCCCCCCCC | 20.04 | 24961812 | |
| 759 | Phosphorylation | ANNYDITTRKKHSSC HCCCCCCCCCCCCCC | 40.60 | 24961812 | |
| 779 | Phosphorylation | QAVVRPASGRISISR EEEECCCCCCEEEEE | 31.15 | 23749301 | |
| 783 | Phosphorylation | RPASGRISISRVQSI CCCCCCEEEEEEEEE | 17.10 | 23749301 | |
| 789 | Phosphorylation | ISISRVQSIAITPTK EEEEEEEEEEECCCC | 15.89 | 25704821 | |
| 793 | Phosphorylation | RVQSIAITPTKELSI EEEEEEECCCCEEEC | 18.84 | 22369663 | |
| 795 | Phosphorylation | QSIAITPTKELSIVD EEEEECCCCEEECCC | 28.62 | 22369663 | |
| 799 | Phosphorylation | ITPTKELSIVDPEQN ECCCCEEECCCCCCC | 22.97 | 28889911 | |
| 808 | Phosphorylation | VDPEQNKSNSVIEEI CCCCCCCCCCHHHHH | 41.72 | 22369663 | |
| 810 | Phosphorylation | PEQNKSNSVIEEISE CCCCCCCCHHHHHHH | 31.40 | 22369663 | |
| 816 | Phosphorylation | NSVIEEISEIEPLNL CCHHHHHHHCCCCCC | 35.48 | 21440633 | |
| 825 | Phosphorylation | IEPLNLEYNKKSALY CCCCCCCCCCCCCCC | 35.13 | 19823750 | |
| 850 | Phosphorylation | STSKLFESAQNSPLK EHHHHHHHHHCCCCC | 28.02 | 22369663 | |
| 854 | Phosphorylation | LFESAQNSPLKQTQN HHHHHHCCCCCCCCC | 21.38 | 22369663 | |
| 934 | Phosphorylation | RGNQDIISNTSSLHE HCCCCHHHCCCCHHE | 34.10 | 23749301 | |
| 936 | Phosphorylation | NQDIISNTSSLHELK CCCHHHCCCCHHEEE | 16.95 | 19779198 | |
| 937 | Phosphorylation | QDIISNTSSLHELKT CCHHHCCCCHHEEEE | 34.84 | 23749301 | |
| 938 | Phosphorylation | DIISNTSSLHELKTI CHHHCCCCHHEEEEE | 31.54 | 25752575 | |
| 944 | Phosphorylation | SSLHELKTIDLSDSN CCHHEEEEEECCCCC | 32.14 | 21440633 | |
| 948 | Phosphorylation | ELKTIDLSDSNNDLE EEEEEECCCCCCCCC | 34.93 | 22369663 | |
| 950 | Phosphorylation | KTIDLSDSNNDLESP EEEECCCCCCCCCCC | 33.87 | 22369663 | |
| 956 | Phosphorylation | DSNNDLESPSTHAKN CCCCCCCCCCCCCCC | 31.29 | 22369663 | |
| 958 | Phosphorylation | NNDLESPSTHAKNNK CCCCCCCCCCCCCCC | 41.95 | 22369663 | |
| 959 | Phosphorylation | NDLESPSTHAKNNKY CCCCCCCCCCCCCCE | 29.27 | 22369663 | |
| 966 | Phosphorylation | THAKNNKYFFSPDDG CCCCCCCEEECCCCC | 16.39 | 23749301 | |
| 969 | Phosphorylation | KNNKYFFSPDDGSID CCCCEEECCCCCCCC | 19.95 | 23749301 | |
| 974 | Phosphorylation | FFSPDDGSIDVASPM EECCCCCCCCCCCCC | 23.70 | 28152593 | |
| 979 | Phosphorylation | DGSIDVASPMKNVEE CCCCCCCCCCCCHHH | 25.94 | 28152593 | |
| 1028 | Phosphorylation | RNTRRANSESAFTGS CCCHHCCCCHHHCCC | 31.76 | 22369663 | |
| 1030 | Phosphorylation | TRRANSESAFTGSLN CHHCCCCHHHCCCCC | 28.62 | 22369663 | |
| 1035 | Phosphorylation | SESAFTGSLNKKNLN CCHHHCCCCCCCCHH | 26.22 | 23749301 | |
| 1051 | Phosphorylation | IANMLDDSINDDPIT HHHHHHHHCCCCHHH | 23.98 | 21440633 | |
| 1078 | Phosphorylation | IPEKPENTKSSDAIG CCCCCCCCCCCCCCC | 30.55 | 28889911 | |
| 1080 | Phosphorylation | EKPENTKSSDAIGIK CCCCCCCCCCCCCCC | 31.26 | 22369663 | |
| 1081 | Phosphorylation | KPENTKSSDAIGIKT CCCCCCCCCCCCCCH | 32.39 | 22369663 | |
| 1089 | Phosphorylation | DAIGIKTSKLADEVE CCCCCCHHHHCHHHH | 22.22 | 21440633 | |
| 1105 | Phosphorylation | LNLNNLPSFQNSPAE HCCCCCCCCCCCHHH | 42.50 | 28152593 | |
| 1109 | Phosphorylation | NLPSFQNSPAEKRKS CCCCCCCCHHHHHHH | 18.07 | 28152593 | |
| 1116 | Phosphorylation | SPAEKRKSLLIERRR CHHHHHHHHHHHHHH | 32.23 | 22890988 | |
| 1125 | Phosphorylation | LIERRRQTIMNIPFT HHHHHHHHHHCCCCC | 22.00 | 28889911 | |
| 1132 | Phosphorylation | TIMNIPFTPDQSEKE HHHCCCCCCCHHHCC | 22.17 | 28152593 | |
| 1136 | Phosphorylation | IPFTPDQSEKEGFTS CCCCCCHHHCCCCCC | 59.00 | 30377154 | |
| 1143 | Phosphorylation | SEKEGFTSSSPEKID HHCCCCCCCCCCEEE | 26.93 | 27717283 | |
| 1144 | Phosphorylation | EKEGFTSSSPEKIDV HCCCCCCCCCCEEEC | 47.02 | 30377154 | |
| 1145 | Phosphorylation | KEGFTSSSPEKIDVS CCCCCCCCCCEEECC | 36.52 | 28889911 | |
| 1340 | Phosphorylation | PSLDRNYSTIRNLLN CCCCCCHHHHHHHHH | 22.40 | 21126336 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LTE1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LTE1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LTE1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219; SER-222; SER-247;SER-249; SER-271; SER-306; SER-527; SER-689; THR-793; SER-948; SER-956AND SER-1028, AND MASS SPECTROMETRY. | |
