EF3B_YEAST - dbPTM
EF3B_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EF3B_YEAST
UniProt AC P53978
Protein Name Elongation factor 3B
Gene Name HEF3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1044
Subcellular Localization
Protein Description Weakly expressed functional homolog of translation elongation factor 3A (YEF3), not required for survival. Can complement loss of YEF3 when expressed from the YEF3 or ADH1 promoters. Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis. Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied..
Protein Sequence MSDSQQSITVLEELFRKLETATSETREGISSELSSFLNGNIIEHDVPEVFFDEFQKAIQSKQKALNTLGAVAYIANETNLSPSVEPYIVATVPSVCSKAGSKDNDVQLAATKALKAIASAVNPVAVKALLPHLIHSLETSNKWKEKVAVLEVISVLVDAAKEQIALRMPELIPVLSESMWDTKKGVKEAATTTITKATETVDNKDIERFIPKLIECIANPNEVPETVHLLGATTFVAEVTPATLSIMVPLLSRGLAERETSIKRKAAVIIDNMCKLVEDPQVVAPFLGKLLPGLKNNFATIADPEAREVTLKALKTLRRVGNVGEDDVLPEISHAGDVSTTLGVIKELLEPEKVAPRFTIVVEYIAAIAANLIDERIIDQQTWFTHVTPYMTIFLHEKTAKEILDDFRKRAVDNIPVGPNFQDEEDEGEDLCNCEFSLAYGAKILLNKTQLRLKRGRRYGLCGPNGAGKSTLMRSIANGQVDGFPTQDECRTVYVEHDIDNTHSDMSVLDFVYSGNVGTKDVITSKLKEFGFSDEMIEMPIASLSGGWKMKLALARAVLKDADILLLDEPTNHLDTVNVEWLVNYLNTCGITSVIVSHDSGFLDKVCQYIIHYEGLKLRKYKGNLSEFVQKCPTAQSYYELGASDLEFQFPTPGYLEGVKTKQKAIVKVSNMTFQYPGTTKPQVSDVTFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSGEVYTHENCRIAYIKQHAFAHIESHLDKTPSEYIQWRFQTGEDRETMDRANRQINENDAEAMNKIFKIEGTPRRVAGIHSRRKFKNTYEYECSFLLGENIGMKSERWVPMMSVDNAWLPRGELIESHSKMVAEIDMKEALASGQFRALTRKEIELHCAMLGLDSELVSHSRIRGLSGGQKVKLVLAACTWQRPHLIVLDEPTNYLDRDSLGALSKALKAFEGGVIIITHSAEFTKNLTDEVWAVKDGKMTPSGHNWVAGQGAGPRIEKKEEEGDKFDAMGNKINSGKKKSKLSSAELRKKKKERMKKKKEMGDEYVSSDEDF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSDSQQSIT
------CCHHHHHHH		58.22-
182PhosphorylationLSESMWDTKKGVKEA
HCHHHCCCCCCHHHH		21.1028889911
184UbiquitinationESMWDTKKGVKEAAT
HHHCCCCCCHHHHHH		71.6517644757
187"N6,N6,N6-trimethyllysine"WDTKKGVKEAATTTI
CCCCCCHHHHHHHEE		50.75-
187MethylationWDTKKGVKEAATTTI
CCCCCCHHHHHHHEE		50.75-
187UbiquitinationWDTKKGVKEAATTTI
CCCCCCHHHHHHHEE		50.7517644757
192PhosphorylationGVKEAATTTITKATE
CHHHHHHHEEEECCC		16.1019779198
196UbiquitinationAATTTITKATETVDN
HHHHEEEECCCCCCH		49.8417644757
196MethylationAATTTITKATETVDN
HHHHEEEECCCCCCH		49.84-
196"N6,N6,N6-trimethyllysine"AATTTITKATETVDN
HHHHEEEECCCCCCH		49.84-
198PhosphorylationTTTITKATETVDNKD
HHEEEECCCCCCHHH		33.4723749301
200PhosphorylationTITKATETVDNKDIE
EEEECCCCCCHHHHH		28.8923749301
204UbiquitinationATETVDNKDIERFIP
CCCCCCHHHHHHHHH		56.4723749301
289UbiquitinationVVAPFLGKLLPGLKN
HHHHHHHHHCCCHHC		49.3422817900
443UbiquitinationFSLAYGAKILLNKTQ
CHHHHHCEEEECCHH		29.5322817900
448UbiquitinationGAKILLNKTQLRLKR
HCEEEECCHHHHHHC		37.3023749301
449PhosphorylationAKILLNKTQLRLKRG
CEEEECCHHHHHHCC		31.5921440633
525PhosphorylationGTKDVITSKLKEFGF
CCHHHHHHHHHHHCC		25.5227017623
551UbiquitinationLSGGWKMKLALARAV
CCCCHHHHHHHHHHH		27.2123749301
707UbiquitinationIGPNGAGKSTLINVL
ECCCCCCHHHHHHHH		39.4723749301
708PhosphorylationGPNGAGKSTLINVLT
CCCCCCHHHHHHHHC		27.7728889911
709PhosphorylationPNGAGKSTLINVLTG
CCCCCHHHHHHHHCC		34.8329136822
715PhosphorylationSTLINVLTGELLPTS
HHHHHHHCCCCCCCC		25.0730377154
721PhosphorylationLTGELLPTSGEVYTH
HCCCCCCCCCCEECC		49.7028889911
726PhosphorylationLPTSGEVYTHENCRI
CCCCCCEECCCCCEE		9.7028889911
727PhosphorylationPTSGEVYTHENCRIA
CCCCCEECCCCCEEE		28.0828889911
735PhosphorylationHENCRIAYIKQHAFA
CCCCEEEEEHHHHHH		13.2819779198
737UbiquitinationNCRIAYIKQHAFAHI
CCEEEEEHHHHHHHH		24.2924961812
750UbiquitinationHIESHLDKTPSEYIQ
HHHHHHCCCHHHHHH		69.5617644757
751PhosphorylationIESHLDKTPSEYIQW
HHHHHCCCHHHHHHH		31.5428889911
753PhosphorylationSHLDKTPSEYIQWRF
HHHCCCHHHHHHHHH		48.5428889911
755PhosphorylationLDKTPSEYIQWRFQT
HCCCHHHHHHHHHCC		11.6219779198
762PhosphorylationYIQWRFQTGEDRETM
HHHHHHCCCCCHHHH		39.5717287358
768PhosphorylationQTGEDRETMDRANRQ
CCCCCHHHHHHHHHH		25.8417287358
786UbiquitinationNDAEAMNKIFKIEGT
HHHHHHHHHHEEECC		36.1123749301
789UbiquitinationEAMNKIFKIEGTPRR
HHHHHHHEEECCCCC		43.2323749301
789MethylationEAMNKIFKIEGTPRR
HHHHHHHEEECCCCC		43.23-
789"N6,N6,N6-trimethyllysine"EAMNKIFKIEGTPRR
HHHHHHHEEECCCCC		43.23-
793PhosphorylationKIFKIEGTPRRVAGI
HHHEEECCCCCCCCH		10.7923749301
807UbiquitinationIHSRRKFKNTYEYEC
HHCCCCCCCCEEEEE		51.9523749301
825UbiquitinationLGENIGMKSERWVPM
HCCCCCCCCCCEEEE		43.9123749301
850PhosphorylationGELIESHSKMVAEID
HHHHHHHHHEEEECC		31.5527017623
864PhosphorylationDMKEALASGQFRALT
CHHHHHHHCCCHHHH		33.7027017623
902UbiquitinationRGLSGGQKVKLVLAA
CCCCCCHHEEEEEEE		44.6123749301
937UbiquitinationDSLGALSKALKAFEG
HHHHHHHHHHHHHCC		59.6023749301
972PhosphorylationAVKDGKMTPSGHNWV
EEECCCCCCCCCCCC		20.14-
974PhosphorylationKDGKMTPSGHNWVAG
ECCCCCCCCCCCCCC		43.44-
1013AcetylationNSGKKKSKLSSAELR
CCCCCCCCCCHHHHH		62.3625381059
1015PhosphorylationGKKKSKLSSAELRKK
CCCCCCCCHHHHHHH		31.1022369663
1016PhosphorylationKKKSKLSSAELRKKK
CCCCCCCHHHHHHHH		35.8822369663
1037PhosphorylationKKEMGDEYVSSDEDF
HHHHCCCCCCCCCCC		15.4627214570
1039PhosphorylationEMGDEYVSSDEDF--
HHCCCCCCCCCCC--		31.0427214570
1040PhosphorylationMGDEYVSSDEDF---
HCCCCCCCCCCC---		34.6727214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EF3B_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EF3B_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EF3B_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PRS6A_YEASTRPT5physical
18757749
KOG1_YEASTKOG1physical
22043304
TRK1_YEASTTRK1genetic
25887987
CHK1_YEASTCHK1genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
RTF1_YEASTRTF1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
CANB_YEASTCNB1genetic
27708008
VPS9_YEASTVPS9genetic
27708008
VPS68_YEASTVPS68genetic
27708008
BUD21_YEASTBUD21genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EF3B_YEAST

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Related Literatures of Post-Translational Modification

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