RS10A_YEAST - dbPTM
RS10A_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RS10A_YEAST
UniProt AC Q08745
Protein Name 40S ribosomal protein S10-A {ECO:0000303|PubMed:9559554}
Gene Name RPS10A {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 105
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. [PubMed: 22096102 eS10 plays a role as a positive regulator of the GCN2 kinase activity by stimulating GCN1-mediated GCN2 activation]
Protein Sequence MLMPKEDRNKIHQYLFQEGVVVAKKDFNQAKHEEIDTKNLYVIKALQSLTSKGYVKTQFSWQYYYYTLTEEGVEYLREYLNLPEHIVPGTYIQERNPTQRPQRRY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Ubiquitination---MLMPKEDRNKIH
---CCCCHHHHHHHH		59.2823749301
5Succinylation---MLMPKEDRNKIH
---CCCCHHHHHHHH		59.2823954790
10UbiquitinationMPKEDRNKIHQYLFQ
CCHHHHHHHHHHHHH		42.3223749301
10AcetylationMPKEDRNKIHQYLFQ
CCHHHHHHHHHHHHH		42.3225381059
24UbiquitinationQEGVVVAKKDFNQAK
HCCCEEEECCHHHHH		41.0623749301
25UbiquitinationEGVVVAKKDFNQAKH
CCCEEEECCHHHHHH		58.7923749301
31UbiquitinationKKDFNQAKHEEIDTK
ECCHHHHHHHHCCCC		41.6123749301
37PhosphorylationAKHEEIDTKNLYVIK
HHHHHCCCCHHHHHH		27.7428889911
38UbiquitinationKHEEIDTKNLYVIKA
HHHHCCCCHHHHHHH		41.0023749301
44UbiquitinationTKNLYVIKALQSLTS
CCHHHHHHHHHHHCC		32.7623749301
48PhosphorylationYVIKALQSLTSKGYV
HHHHHHHHHCCCCCE		34.1722369663
50PhosphorylationIKALQSLTSKGYVKT
HHHHHHHCCCCCEEE		33.3722369663
51PhosphorylationKALQSLTSKGYVKTQ
HHHHHHCCCCCEEEE		29.4022369663
52UbiquitinationALQSLTSKGYVKTQF
HHHHHCCCCCEEEEE		49.3723749301
56UbiquitinationLTSKGYVKTQFSWQY
HCCCCCEEEEEEEEE		28.2922817900
98PhosphorylationYIQERNPTQRPQRRY
CCCCCCCCCCCCCCC		40.5319684113
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RS10A_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RS10A_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RS10A_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SRS2_YEASTSRS2genetic
21459050
RS10B_YEASTRPS10Bgenetic
22377630
GCN1_YEASTGCN1physical
25437641
EF3A_YEASTYEF3genetic
25437641
MLH3_YEASTMLH3genetic
27453043
AAKG_YEASTSNF4genetic
27453043
NM111_YEASTNMA111genetic
27453043
HSC82_YEASTHSC82genetic
27453043
PVH1_YEASTYVH1genetic
27453043
KMO_YEASTBNA4genetic
27453043
CYPB_YEASTCPR2genetic
27453043
CYPC_YEASTCPR3genetic
27453043
PGTB2_YEASTBET2genetic
27453043
ATC2_YEASTPMC1genetic
27453043
AGC1_YEASTAGC1genetic
27453043
NHX1_YEASTNHX1genetic
27453043
YJ66_YEASTYJR096Wgenetic
27453043
TBB_YEASTTUB2genetic
27453043
F16P_YEASTFBP1genetic
27453043
KAPA_YEASTTPK1genetic
27453043
TOP1_YEASTTOP1genetic
27453043
MAP1_YEASTMAP1genetic
27453043
TRX2_YEASTTRX2genetic
27453043
DCAM_YEASTSPE2genetic
27453043
SRO7_YEASTSRO7genetic
27453043
SHU1_YEASTSHU1genetic
27453043
MUP3_YEASTMUP3genetic
27453043
FNTA_YEASTRAM2genetic
27453043
BXI1_YEASTBXI1genetic
27453043
QCR2_YEASTQCR2genetic
27453043
RSC8_YEASTRSC8genetic
27453043
YPT32_YEASTYPT32genetic
27453043
ADE_YEASTAAH1genetic
27453043
RPB3_YEASTRPB3genetic
27453043
DCOR_YEASTSPE1genetic
27453043
TSC10_YEASTTSC10genetic
27453043
YND1_YEASTYND1genetic
27453043
RPAC1_YEASTRPC40genetic
27453043
AIM33_YEASTAIM33genetic
27453043
VPS15_YEASTVPS15genetic
27453043
UBA4_YEASTUBA4genetic
27453043
MET32_YEASTMET32genetic
27453043
FLX1_YEASTFLX1genetic
27453043
G3P3_YEASTTDH3genetic
27453043
PNPH_YEASTPNP1genetic
27453043
SCH9_YEASTSCH9genetic
27453043
AGP1_YEASTAGP1genetic
27453043
YIA6_YEASTYIA6genetic
27453043
GABAT_YEASTUGA1genetic
27453043
KC12_YEASTYCK2genetic
27453043
INO2_YEASTINO2genetic
27453043
DOM34_YEASTDOM34genetic
27453043
CTK3_YEASTCTK3genetic
27453043
LSM1_YEASTLSM1genetic
27453043
AZF1_YEASTAZF1genetic
27453043
KCC4_YEASTKCC4genetic
27453043
COQ6_YEASTCOQ6genetic
27453043
SNF1_YEASTSNF1genetic
27453043
SWI5_YEASTSWI5genetic
27453043
PLP1_YEASTPLP1genetic
27453043
PUT2_YEASTPUT2genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RS10A_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND MASSSPECTROMETRY.

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