| UniProt ID | AAKG_YEAST | |
|---|---|---|
| UniProt AC | P12904 | |
| Protein Name | 5'-AMP-activated protein kinase subunit gamma | |
| Gene Name | SNF4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 322 | |
| Subcellular Localization | Nucleus . Cytoplasm . | |
| Protein Description | Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (SNF1) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.. | |
| Protein Sequence | MKPTQDSQEKVSIEQQLAVESIRKFLNSKTSYDVLPVSYRLIVLDTSLLVKKSLNVLLQNSIVSAPLWDSKTSRFAGLLTTTDFINVIQYYFSNPDKFELVDKLQLDGLKDIERALGVDQLDTASIHPSRPLFEACLKMLESRSGRIPLIDQDEETHREIVVSVLTQYRILKFVALNCRETHFLKIPIGDLNIITQDNMKSCQMTTPVIDVIQMLTQGRVSSVPIIDENGYLINVYEAYDVLGLIKGGIYNDLSLSVGEALMRRSDDFEGVYTCTKNDKLSTIMDNIRKARVHRFFVVDDVGRLVGVLTLSDILKYILLGSN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Ubiquitination | ------MKPTQDSQE ------CCCCCCHHH | 57.69 | 23749301 | |
| 4 | Phosphorylation | ----MKPTQDSQEKV ----CCCCCCHHHCC | 39.22 | 19823750 | |
| 7 | Phosphorylation | -MKPTQDSQEKVSIE -CCCCCCHHHCCCHH | 30.35 | 19823750 | |
| 61 | Phosphorylation | LNVLLQNSIVSAPLW HHHHHHCCCCCCCCC | 16.06 | 27017623 | |
| 70 | Phosphorylation | VSAPLWDSKTSRFAG CCCCCCCCCCHHHCC | 26.67 | 27017623 | |
| 72 | Phosphorylation | APLWDSKTSRFAGLL CCCCCCCCHHHCCCC | 29.14 | 28889911 | |
| 73 | Phosphorylation | PLWDSKTSRFAGLLT CCCCCCCHHHCCCCC | 29.19 | 28889911 | |
| 81 | Phosphorylation | RFAGLLTTTDFINVI HHCCCCCHHHHHHHH | 25.08 | 28889911 | |
| 172 | Ubiquitination | LTQYRILKFVALNCR HHHHHHHHHHHHCCC | 35.11 | 23749301 | |
| 185 | Acetylation | CRETHFLKIPIGDLN CCCCEEEEEEECCEE | 45.55 | 24489116 | |
| 276 | Ubiquitination | EGVYTCTKNDKLSTI CCEEEECCCCCCHHH | 66.35 | 23749301 | |
| 279 | Acetylation | YTCTKNDKLSTIMDN EEECCCCCCHHHHHH | 54.45 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AAKG_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AAKG_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AAKG_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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