dbPTM

MTU1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MTU1_YEAST
UniProt AC	Q12093
Protein Name	Mitochondrial tRNA-specific 2-thiouridylase 1
Gene Name	SLM3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	417
Subcellular Localization	Mitochondrion .
Protein Description	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base..
Protein Sequence	MLARYLNLIGRRSASPYRPQRLPAKFDNVIVAMSSGVDSSVAAALFAGEFPNTRGVYMQNWSESQSLDDPGKEPCYERDWRDVNRVAKHLNIRVDKVNFEQDYWIDVFEPMLRGYSEGSTPNPDIGCNKFVKFGKLREWLDEKYGTGNYWLVTGHYARVMQEMNGKGLFHLLRSIYRPKDQSYYLSQINSTVLSSLLLPIGHLTKPEVRDLAKYAGLPTAEKPDSQGICFVNNSQHGKFKNFLKHYLPSSPGDIITVDPQSGAKTTWGRHDGLWSYTIGQKVGISMPQADPNYQGTWFVSEKLRDTNEILIVRGRDNPALYSDTMRIENFSSLGPREDTINAFQNTGALTLQFRSLQVPVQIKSCKLNRSADNLDITIHLASKQRAITPGQSCCLYIDDRVLGSGPISHVNNNDTHA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
277	Phosphorylation	HDGLWSYTIGQKVGI CCCEEEEECCCEEEE	17.08	19684113

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MTU1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MTU1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MTU1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP60_YEAST	HSP60	physical	16429126
RSC6_YEAST	RSC6	genetic	17314980
DEP1_YEAST	DEP1	genetic	17314980
ISW1_YEAST	ISW1	genetic	17314980
NHP10_YEAST	NHP10	genetic	17314980
REI1_YEAST	REI1	genetic	17314980
PAF1_YEAST	PAF1	genetic	17314980
VPS8_YEAST	VPS8	genetic	17314980
MSS1_YEAST	MSS1	genetic	20004207
UBC4_YEAST	UBC4	genetic	27708008
SDS3_YEAST	SDS3	genetic	27708008
GSF2_YEAST	GSF2	genetic	27708008
GLYM_YEAST	SHM1	genetic	27708008
PEX5_YEAST	PEX5	genetic	27708008
SWR1_YEAST	SWR1	genetic	27708008
RTR1_YEAST	RTR1	genetic	27708008
GCN1_YEAST	GCN1	genetic	27708008
RTF1_YEAST	RTF1	genetic	27708008
PEX8_YEAST	PEX8	genetic	27708008
TIM13_YEAST	TIM13	genetic	27708008
NPR3_YEAST	NPR3	genetic	27708008
PTH_YEAST	PTH1	genetic	27708008
MPM1_YEAST	MPM1	genetic	27708008
IME2_YEAST	IME2	genetic	27708008
SET2_YEAST	SET2	genetic	27708008
PEX2_YEAST	PEX2	genetic	27708008
FABG_YEAST	OAR1	genetic	27708008
YRA2_YEAST	YRA2	genetic	27708008
TRM2_YEAST	TRM2	genetic	27708008
TOP3_YEAST	TOP3	genetic	27708008
ATP10_YEAST	ATP10	genetic	27708008
CDC73_YEAST	CDC73	genetic	27708008
TDA5_YEAST	TDA5	genetic	27708008
MSS1_YEAST	MSS1	genetic	27708008
PEX12_YEAST	PEX12	genetic	27708008
SUB1_YEAST	SUB1	genetic	27708008
RCO1_YEAST	RCO1	genetic	27708008
LSM7_YEAST	LSM7	genetic	27708008
ATP23_YEAST	ATP23	genetic	27708008
LEO1_YEAST	LEO1	genetic	27708008
MBF1_YEAST	MBF1	genetic	27708008
LGE1_YEAST	LGE1	genetic	27708008
LPE10_YEAST	MFM1	genetic	27708008
JID1_YEAST	JID1	genetic	27708008
YP084_YEAST	YPR084W	genetic	27708008
SYEM_YEAST	MSE1	genetic	27811238

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MTU1_YEAST

Related Literatures of Post-Translational Modification